As far as pain sometimes, it is the same for e with Testosterone injections. I do sub q and sometimes I can not feel a thing, other time a small sting. My wife is a nurse practitioner and she says sometimes you hit directly on a nerve, thus the sting. Just my 2 cents

I did 10 mg per day for a number of years. My goal was to try to control my hematocrit levels. It did help that a bit. Levels were steady. I have experimented with several dosages and timing. I have recently switched to creams to try to slow down red blood cell production

I notice that when my E2, estradoil, gets on the high side this can happen.