Testosterone

[Stenlie_]

Okay, I really don't understand. It turns out that there is no case in which testosterone is the cause of ED. Why, then, do all andrologists, urologists, and endocrinologists claim that low testosterone or hormonal imbalance causes ED? In general, there is a good logic - when there is no libido - there is not enough desire, which in itself can cause a weak erection. Is it possible that just testosterone replacement therapy is not right? Or does testosterone simply have nothing to do with an erection? Also, pharmaceutical companies that test for erectile dysfunction EXCLUDE from the test all men with low testosterone? Does this mean that there is still a link between testosterone and erection? Or everything is wrong

[tomas1]

I know people differ, but I never found T to help the ED, but it was a double-edged sword by increasing libido. That was what happened to me.

[Simbarn]

Most MD's and Uro's don't know shit about TRT! I get my injectables from very legit Royalmedicalcenters.com in Florida. Google or Face Book them for more. Those people have been a life changer for me cause that's all they do! My testosterone cypionate is mixed with anastrozole which is an estrogen blocker (Must do!) Also inject Gonadorelin which tells pituitary gland to tell my boys to produce more natural T otherwise my junk will shrink. I'm 77 and my T level now about 900-1100 like when I was 28. NO SIDE EFFECTS
Totally legit US outfit!! DO your homework kids.

Kidagain73, I agree with you, many doctors are not up to date with modern thinking of new protocols with regard to hormone replacement for men. I am very interested in your Gonadorelin addition to your treatment. As this is aimed at addressing the biggest flaw I have seen with TRT and that is the loss of “upstream hormones” which I have discussed in detail in previous posts. This is one of the main reasons testosterone replacement DOES NOT WORK with regard to improving sexual function for many men. The loss of gonadotropins can cause many sexual dysfunctions in the male. It is such a basic premise, one many doctors overlook. Dr. John Crisler understood this and tried to compensate for this loss by adding HCG to many guys protocols in order to at least replace luteinizing hormone (LH). This was all that was available during that time. Unfortunately it does not work well for all men and can lose effectiveness over time.
I was very sceptical about Gonadorelin being used to stimulate sufficient gonadotropins as it is extremely short acting in the body and needs to be injected multiple times a day in order for it to have any effect? However it appears to be working in your case which I would be very interested to hear more about. I sent you a PM some time ago about this.

I do not agree with the obligatory addition of Anastrozole in every TRT protocol. Aromatase inhibitors can lower estrogen in some men very quickly and uncontrollably and cause a low estrogen problem which is actually worse than high estrogen. If the amount of Testosterone being administered is correct for the individual, these drugs for the most part should not be needed. If you are taking too much testosterone then yes, your body will convert the excess into other hormones. Before Dr. Crisler passed away he began to recognise how detrimental these drugs can be.

You have mentioned that your T level is now 900-1100 and that this is what your T level was when you were in your 20’s. Is this just a belief that men in their twenties have a testosterone level of around 1000 or did you actually have tests done in your 20’s that showed you had a T level in this very high range?
Many healthy young men have a T level around 400-500 ng/dl. This is ample for them as their sensitivity to the hormone is suited to that level, that is, how the androgen receptors respond to their unique genetic programmed level of T in the genes.

[Simbarn]

Okay, I really don't understand. It turns out that there is no case in which testosterone is the cause of ED. Why, then, do all andrologists, urologists, and endocrinologists claim that low testosterone or hormonal imbalance causes ED? In general, there is a good logic - when there is no libido - there is not enough desire, which in itself can cause a weak erection. Is it possible that just testosterone replacement therapy is not right? Or does testosterone simply have nothing to do with an erection? Also, pharmaceutical companies that test for erectile dysfunction EXCLUDE from the test all men with low testosterone? Does this mean that there is still a link between testosterone and erection? Or everything is wrong

To answer your question properly would take some time Stenlie. Loss of testosterone can and does cause ED. Testosterone has complex actions in the male genitals. Put simply, testosterone affects erectile function indirectly. After puberty, it is very important for maintaining the health of the erectile tissues in the corpus cavernosum, specifically the content and health of smooth muscle and preventing it from being lost and thus replaced with non-compliant tissue such as collagen; commonly called fibrosis. It is also extremely important for maintaining the health and function of the endothelium in the vascular areas of the erectile tissues, the production of adequate NO and other vital enzymes. Testosterone also helps to mitigate the effects of oxidative stress. Oxidative stress is one of the main culprits causing deterioration of the above tissues as we age.

When testosterone levels decline, gradually over time, the penis undergoes physiological changes in the erectile bodies that begin to cause CVOD. If these changes have occurred for a long period, that is many years, replacing testosterone at that point is evidently not enough to reverse the damage, it may help considerably if caught early. However, as I have discussed many times on FT, testosterone replacement has its own issues and does not help sexual function for many men due to the loss of other hormones which it causes. This in itself can exacerbate ED.

Erectile dysfunction is caused by many other etiologies other than just low T of course. Even if low T was the initial catalyst in the condition, other conditions can develop which further complicate any form of a cure. So it is rarely as simple as just replacing the lost testosterone as this for most men does not cure the ED.

Nocturnal erections are a little different to those we get when awake in so far as they are very testosterone dependent. That is, when testosterone is very low, they stop occurring. This also contributes to the decline in penile health.

[kidagain73]

Everybody's mileage can vary. What I'm doing now via Royal Medical Centers protocol is working well with adding 80 mg of sildenafil 90 mins out. At 77 yo I'm thankful, believe me. Go to their website and many of your questions will be covered.
My biggest ED cause is using condoms as being a 70's guy we never had to use them but because I see several escorts it's a must do with them. Female condoms work better for me but still a condom but much looser. Sure wish I could find a bbfs girl before I die, lol.
As for your Gonadorelin question it's an upgrade from HCG and you don't have to mix it. I inject 50 units subcutaneously in lower abdomen 2x per wk then on alternate days I inject .02-1/2 mls of the Testo also subcutaneously and this combo keeps me from spiking T levels and keeps them level at all times.

When the time comes nd it will I'll prob go to Cavorject but that scares me.

Good luck guys, hope this helped.

Jeff in NJ

[Simbarn]

Everybody's mileage can vary. What I'm doing now via Royal Medical Centers protocol is working well with adding 80 mg of sildenafil 90 mins out. At 77 yo I'm thankful, believe me. Go to their website and many of your questions will be covered.
My biggest ED cause is using condoms as being a 70's guy we never had to use them but because I see several escorts it's a must do with them. Female condoms work better for me but still a condom but much looser. Sure wish I could find a bbfs girl before I die, lol.
As for your Gonadorelin question it's an upgrade from HCG and you don't have to mix it. I inject 50 units subcutaneously in lower abdomen 2x per wk then on alternate days I inject .02-1/2 mls of the Testo also subcutaneously and this combo keeps me from spiking T levels and keeps them level at all times.

When the time comes nd it will I'll prob go to Cavorject but that scares me.

Good luck guys, hope this helped.

Jeff in NJ

Thank you for the reply Jeff. This is fascinating regarding your experience with Gonadorelin. I am much more interested in your experience with it than what the website says at Royal Medical as I have always found talking to guys over the years who are trying new protocols to be far more revealing. Clinics can make all sorts of claims and what they deliver may be entirely different.

May I ask a few questions?

How long have you been on testosterone for?
Since being on subq T and the Gonadorelin protocol, you have noticed no testicular shrinkage correct?
Have you noticed any loss of ejaculate volume?
Have you noticed any change in sexual sensitivity in the penis itself being either an improvement, loss or does it come and go?
Has your refractory period changed; that is the ability or urge to ejaculate again: has it shortened or lengthened?
Has the ability to get and maintain an erection on your own changed?
Has Royal medical done regular labs of your LH and FSH levels since you have been on this protocol to see how much your pituitary is producing from the Gonadorelin stimulation?
(I would assume they are doing regular labs for you to monitor your T and E2 levels? Given that they are using Gonadorelin in your protocol, are they also testing for LH and perhaps FSH to see how you are responding to the GNRH stimulation?)

The above questions and their answers are very telling in regard to how you have been affected positively or negatively with regard to sexual function and the T replacement protocol you are on and the possible loss and subsequent replacement of gonadotropins.
Sorry if you have answered some of these before, but it would be good to have the answers here in one reply.

Some of the guys over at Excelmale do not think that Gonadorelin would work as well as HCG owing to its extremely short half-life. However, with what Royal medical are reporting with their tests results on their web site and the substantial increase in LH they are purporting to have achieved with their twice weekly dose with Gonadorelin, this would appear to not be the case. The other advantage I see with this over HCG is the increase in FSH that “should” be occurring too from GNRH stimulation. They do not show any labs for FSH unfortunately.

If this protocol you are on is successfully enabling a reasonable level of natural gonadotropins (LH and FSH) to be produced whilst on exogenous T supplementation, then without doubt, this is quite a leap forward in hormone replacement for men. The loss of these hormones causes many issues for men, especially younger men. Hence my extreme interest in this topic. If it is working for a man of your age, it could be even more promising for younger men on TRT who do not function well on testosterone alone or even with HCG added to their protocols.

Thank you again for your help with this.

[Simbarn]

Bumping this for Kidagain73.