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I've battled sexual performance anxiety (coital anxiety, I am able to attain an erection but lose it just before penetration) for over 20 years but a combination of Cialis + oral phentolamine as needed was very effective for the last 10 years or so.

It seems, however, that Cialis has stopped for working for me and now I'm working on a new regimen.

Because erections start in the brain, I've been looking for a centrally acting drug to improve my sexual performance. I've tried trazodone, cabergoline and apomorphine but nothing worked.

Do you think acetylcholine could be helpful?

I don't know much about acetylcholine but there are studies that show its importance in erectile function.

I also know that there are no acetylcholine supplements but CDP choline and Alpha GPC are two percursors and there are supplements that combine both of them.

Do you think I should give these supplements a try? If so, how should I take them (regularly or only as needed)?

If you know any studies on acetylcholine and ED, please share them here.

Thanks in advance!

I thought apomorphine worked for you?

I regularly use citocholline or Alpha GPC as both are great for cognitive function. But neither has had any impact on erections for me.

Jeff775 wrote:I thought apomorphine worked for you?

[...]

I'm afraid it didn't.

I knew apomorphine was only a 2nd line treatment and I always said so here but I when I actually tried it in combination with avanafil, it did more harm than good: sedation, no arousal and side effects were unbearable, esp. hypotension. I'm not going to give it a second try.

I remember I had the exact same result when I tried cabergoline a few years ago. Centrally acting drugs (cabergoline, apomorphine, trazodone) may work for many people but apparently not for me.

Jeff775 wrote:I regularly use citocholline or Alpha GPC as both are great for cognitive function. But neither has had any impact on erections for me.

Do you think they reduce anxiety and promote relaxation? Is there a sedation effect?

Flavio wrote:

Jeff775 wrote:I regularly use citocholline or Alpha GPC as both are great for cognitive function. But neither has had any impact on erections for me.

Do you think they reduce anxiety and promote relaxation? Is there a sedation effect?

Definitely no sedation effect at all for me. There might be a small reduction in anxiety but nothing like L Theanine.