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Testosterone = male hormone
Estradiol = female hormone

I've been on TRT for 2+ years and I've been feeling tired lately.
I had a blood test to check my testosterone level. Total T was 661. The report said normal is 450 to 780.
They also checked my estradiol level. With a normal male range of 0-48, mine was 90...yikes!!
So, the doctor explained the estradiol almost always goes UP on testosterone replacement therapy. To counteract the effects of too much estradiol, he prescribed anastrozole.
Anyone had their "estradiol" level checked?

Now I know why my boobs/man glands/hooters were getting bigger.
stmfttr

Anastrozole is an estrogen blocker and it comes mixed in with my Testosterone Cypionate, that`s why I use RMC cause they know their shit.

stmfttr wrote:Testosterone = male hormone
Estradiol = female hormone

I've been on TRT for 2+ years and I've been feeling tired lately.
I had a blood test to check my testosterone level. Total T was 661. The report said normal is 450 to 780.
They also checked my estradiol level. With a normal male range of 0-48, mine was 90...yikes!!
So, the doctor explained the estradiol almost always goes UP on testosterone replacement therapy. To counteract the effects of too much estradiol, he prescribed anastrozole.
Anyone had their "estradiol" level checked?

Now I know why my boobs/man glands/hooters were getting bigger.
stmfttr

How are you taking the testosterone, what amount and when?

Simbarn wrote:

stmfttr wrote:Testosterone = male hormone
Estradiol = female hormone

I've been on TRT for 2+ years and I've been feeling tired lately.
I had a blood test to check my testosterone level. Total T was 661. The report said normal is 450 to 780.
They also checked my estradiol level. With a normal male range of 0-48, mine was 90...yikes!!
So, the doctor explained the estradiol almost always goes UP on testosterone replacement therapy. To counteract the effects of too much estradiol, he prescribed anastrozole.
Anyone had their "estradiol" level checked?

Now I know why my boobs/man glands/hooters were getting bigger.
stmfttr

How are you taking the testosterone, what amount and when?

Every 14 days, 1 mL, rotate between the right and left mid thigh.
When I retest the doctor tells me to have the blood drawn mid-cycle. (7 days after an injection...before 10a.m.)
stmfttr

stmfttr wrote:

Simbarn wrote:

stmfttr wrote:Testosterone = male hormone
Estradiol = female hormone

I've been on TRT for 2+ years and I've been feeling tired lately.
I had a blood test to check my testosterone level. Total T was 661. The report said normal is 450 to 780.
They also checked my estradiol level. With a normal male range of 0-48, mine was 90...yikes!!
So, the doctor explained the estradiol almost always goes UP on testosterone replacement therapy. To counteract the effects of too much estradiol, he prescribed anastrozole.
Anyone had their "estradiol" level checked?

Now I know why my boobs/man glands/hooters were getting bigger.
stmfttr

How are you taking the testosterone, what amount and when?

Every 14 days, 1 mL, rotate between the right and left mid thigh.
When I retest the doctor tells me to have the blood drawn mid-cycle. (7 days after an injection...before 10a.m.)
stmfttr

How many mgs of T in the injection? I would assume 200 given the injection frequency.

The problem with injecting every 2 weeks is the spike of T after each injection. This spike over time causes the body to create more aromatase enzyme to counter what it sees as an unnatural rise in testosterone.
If you are testing at around 661 mid cycle, your initial post injection level most likely goes supraphysiologic. By the end of the cycle you will most likely be quite low and feel the effects of low t.
To counter this, injecting weekly or twice weekly will over time lower the body's aromatase and therefore lower the E2 conversion. This is far more preferable to trying to counter estrogen conversion with an aromatase inhibitor. More frequent injections at a much lower dosage will also make you feel more stable.
It still surprises me how many doctors are completely unaware of this.

Be very careful with the use of aromatase inhibitors as well. They are very potent drugs, designed initially for women with breast cancer. They can easily plummet men's estrogen levels far too low and this will make men feel worse than if they have too much estrogen. It can also take some time for this to correct. Men need a certain amount of estrogen too.