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I'm on a LOT of meds! Looking for tips from others who have narrowed down
which of these are the worst offenders. Doctors seem to not want to talk about
meds & ED..
I am currently using Tri-Mix but not even that seems to work-
• TRAMADOL 50 mg (1 in the morning)
• Lexipro 5mg (Escitalopram) [Trying to stop]
• Eliquis 5mg 2 a day
• Lisinopril 40 mg
• Metoprolol 12.5mg 2 a day
• Amlodipine 5 mg
• Tamsulosin 0.4 mg – 2 a day (Flomax)
• Loratadine
• Omeprazole 40
• amiodarone 200 mg For afib
• FAMOTIDINE 20MG
• Atorvastatin 80 mg
• Doxazosin 4 mg

Wife has early dementia & still likes sex but doesn't help get things started.
Should I just give up?
Thoughts appreciated.

Yeah, a quick web search indicates several of your drugs could contribute to ED. I didn't search anywhere near all of them and didn't follow up with further than the initial list of hits (I didn't read the listed links). Metoprolol for one. Tamsulosin can possibly contribute. Pretty easy to research. If you need the drug what are you going to do?

Agree.. If need not much I can do.. I have see ED as a possibility
on most everything I've looked up.. Thanks..

Dr told if if I would lose 40 pounds he could get me off ALL BP meds. I just had a stress test & passed but do have afib, treated with meds. The COVID 'restrictions' for the past 2 yrs have not helped! (Lack of exercise.) Have a PCP checkup coming in a couple of weeks. Will talk about changes. I just looked FLOMAX up and it says reduces ejaculation volume. hmmm. THanks

Tramadol and lexapro are well-known offenders in the sex department. But that doesn't mean everyone taking them will have problems.

SSRI's such as Lexapro are well known offenders. For me, Lisinopril and Metoprolol were killers.

I also take many meds and have anorgasmia when penetrating
my wife. I found two things very helpful. First, I use a type of
cock ring called Giddy. It's oval vs round (so it doesn't constrict
arteries) and it has nubs on top which constrict the dorsal vein
so venous leak isn't a problem. While it's not everybody's cup
of tea, after intercourse I lie on my back and wife penetrates
my anus to massage the prostate. Best orgasms of my life. There
are more details in the anorgasmia section.

I'm taking Equlis (blood thinner) Amlodipine & yes I am weak as can be. Guess se is a 'pipe dream' for me. haha

That's a lot of meds. Many of them are a possible cause of ED.
I was taking statins, baby aspirin and Imitrex when my ED started. Plus I'm a smoker, which is possibly partly to blame.
If Trimix isn't working there is only one more step, the final one, implant.