FrankTalk.org

Is there any counterindication of using tadalafil and MDMA or mushrooms? I have not found any info.

The main recreational drug interaction I'm aware of is with "poppers", which is not something I'm all that familiar with but I think gay guys use it to relax the anus.

wolfpacker wrote:The main recreational drug interaction I'm aware of is with "poppers", which is not something I'm all that familiar with but I think gay guys use it to relax the anus.

What heppen with poppers?

When it comes to combining Tadalafil with recreational drugs like MDMA or mushrooms, while there isn't a lot of specific information available, it's generally recommended to proceed with caution. Many people use Tadalafil without issues, but since both recreational drugs and Tadalafil can affect your blood pressure and heart rate, it's a good idea to be aware of potential risks like dizziness or headaches.

That said, there’s no major red flag, as long as you’re careful and stay informed. Just avoid using poppers (amyl nitrate), as combining them with Tadalafil can cause a dangerous drop in blood pressure.

If you're curious or concerned, it could be helpful to ask your doctor for more personalized advice, but many people manage fine by being mindful and cautious. Stay safe and enjoy responsibly!