Page 1 of 1
PDE5 efficacy
Posted: Thu Aug 11, 2016 10:03 am
by defiant
What is your understanding of PDE5s?
Does the patient eventually build a resistance to them and thus gain less benefit from the drug?
I have read multiple *reliable* sources that say drugs such as Cialis do not lose efficacy over time, and in actual fact their efficacy is increased.
It is a worry for many.
Re: PDE5 efficacy
Posted: Thu Aug 11, 2016 11:20 am
by dg_moore
Many men here , including myself, report that Cialis et. al. do become ineffective over time. In my case Viagra worked for several years and then suddenly quit. Others have described the same thing.
Re: PDE5 efficacy
Posted: Thu Aug 11, 2016 5:28 pm
by jimmyd24
I have had the same problem.
Viagra worked for me for about 10 -12 years then stopped working.
I then tried MUSE that didn't work at all.
Trimix Gel didn't work ether.
Caverject and Edex worked but made my penis ache.
My uro put me on Trimix and WOW.
Gets me hard in 5 mins and stays hard for almost 2 hours.
Re: PDE5 efficacy
Posted: Fri Aug 12, 2016 10:36 pm
by dtwarren1942
I have been taking Viagra for about 20 years and Cialis for about five. Both slowly lost their effectiveness over time, even while increasing the dose.
About four years ago, I starte using Trimix which has also lost its effectiveness over time.
In my opinion, the loss of effectiveness is due more to the increasing cause of my ED - complications resulting from diabetes.
Re: PDE5 efficacy
Posted: Sat Feb 11, 2017 10:11 pm
by Bjones
jimmyd24 wrote:I have had the same problem.
Viagra worked for me for about 10 -12 years then stopped working.
I then tried MUSE that didn't work at all.
Trimix Gel didn't work ether.
Caverject and Edex worked but made my penis ache.
My uro put me on Trimix and WOW.
Gets me hard in 5 mins and stays hard for almost 2 hours.
Tri is injections sounds extreme to me..im new to this world though and cialis has stopped working as well..what do injections cost? Any loss of sensation?