How quickly does trimix go bad at room temp?

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GoodWood
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How quickly does trimix go bad at room temp?

Postby GoodWood » Thu Oct 10, 2019 2:42 pm

How quickly does trimix go bad at room temp?

If it’s been at room temp for an hour is it still 95% effective? 75%, 50%

How about at 4hours? 8hours?

Has there been any controlled drug tests done?

It would be helpful to know if you were going on a date and didn’t have good options for keeping it cold.
55yo, NYC. ED started at 40. 50 units BiMix + Atropine (Pap 30/Phen 6/Atr 0.2). Prostaglandins caused aching. Doses increasing. A cock ring helps. Phallosan Forte tension devise to maintain size. Eager to talk about implant experiences.

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flyingduck2019
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Re: How quickly does trimix go bad at room temp?

Postby flyingduck2019 » Thu Oct 10, 2019 3:34 pm

Goodwood, a very good question and I bet there are a lot of guys out there who would like the answer. Sometimes, when I know my wife and I are going to have sex I take the syringe out of the fridge and put it in the med cabinet in the bathroom up to an hour before I plan to inject and I have not had any issues.
Phil, 75, married 54 years, ED started about 9 years ago. After viagra and cialis and pumping have found Trimix. Use 10 units injected with a partial erection. 31g-5/16" or 31g 1/2"needle. 10-1-30 :D :D :D Wife likes it too :D :D :D :D

Drawoverfade
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Re: How quickly does trimix go bad at room temp?

Postby Drawoverfade » Thu Oct 10, 2019 9:13 pm

It’s a lot more stable than you think. Check out this published study on the stability of tri-mix at room temperature.

https://www.ncbi.nlm.nih.gov/m/pubmed/23924676/

It looks like after five days at room temp 8% of the alprostadil was lost.

GoodWood
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Re: How quickly does trimix go bad at room temp?

Postby GoodWood » Fri Oct 11, 2019 8:36 am

Drawoverfade wrote:It’s a lot more stable than you think. Check out this published study on the stability of tri-mix at room temperature.

https://www.ncbi.nlm.nih.gov/m/pubmed/23924676/

It looks like after five days at room temp 8% of the alprostadil was lost.




Wow! Only 8% loss at 5 days? Guess I don’t need to worry so much. I keep the vial and some prefilled syringes in the freezer. When I expect to have a hookup after work I grab a small freezer pack/wallet and put a syringe in there. At the end of the workday the pack is still cool but not frozen any longer. Guess it’s still full strength!

Thanks for posting that article!!
55yo, NYC. ED started at 40. 50 units BiMix + Atropine (Pap 30/Phen 6/Atr 0.2). Prostaglandins caused aching. Doses increasing. A cock ring helps. Phallosan Forte tension devise to maintain size. Eager to talk about implant experiences.

Captain1117
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Re: How quickly does trimix go bad at room temp?

Postby Captain1117 » Fri Oct 11, 2019 2:08 pm

Great info.
Thanks for sharing.

So keeping the medication frozen(-20) seems to be best long term solution.
A frozen syringe will still be at room temp after 4-6 hours if in an insulated container.

Helps a lot.
" The greatest benefit of an implant is that a man stops thinking about ED."-Dr.Eid

48, healthy, straight, single.ED after turning 40. AMS LGX implanted by Dr.Yonah Krakowski in June 2023.

dgold21
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Re: How quickly does trimix go bad at room temp?

Postby dgold21 » Fri Oct 11, 2019 3:58 pm

Posted this in another thread, but it applies here

FWIW, I keep pre-filled syringes at the ready, unrefrigerated, for several days with no perceived loss of potency. Just this last weekend, I took five with me for a coastal getaway, just kept them in my travel dopp kit at room temp. No problems at all.
HIFU procedure for prostate cancer (Gleason 4+3) late 2018. Recurrence 2020, HDR Brachytherapy. Nerves spared but traumatized. Tried all PDE5i meds, hit and miss. First trimix inj Feb 2019. 30/1/25. Total ED as of late 2020

newtoed
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Re: How quickly does trimix go bad at room temp?

Postby newtoed » Sun Oct 13, 2019 8:45 pm

I had it out for 10 day at room temperature and did not notice any difference. I still have some Trimix that is about 1.5 years old kept in the fridge and no loss of potency. I think keeping the sterility of the solution is a greater concern.
Age 54, Single, Los Angeles. Stage 2 rectal cancer in 2013. Radiation, surgery, chemo. In remission for 5 years. Some ED before cancer, complete since. 2-3 units of Trimix 40/30/2 2-3 times a week since Feb/2017 with great success!

ftwabeck3533
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Re: How quickly does trimix go bad at room temp?

Postby ftwabeck3533 » Tue Dec 31, 2019 8:03 am

I woke up this morning and found my brand new 5 ml vial of trimix in the bathroom right where I had left it yesterday afternoon. So glad I could search and find this thread, as I was asking myself exactly the same question GoodWood posted a couple month's ago..."How quickly does trimix go bad at room temp?"

Thanks to all who shared their experiences on this topic here -- I won't throw it away, or be concerned about using it, or worried whether it will still be effective.
Born 1955, Erectile Dysfunction, Robotic Prostatectomy (Oct 2018, Dr Bugg @ UCA, Birmingham, AL), PSA<0.007, Trimix User (30 mg Papaverine HCL, 1 mg Phentolamine MES, 10 mcg Alprostadil per 1 ML. My dose is 0.16 ML)

mcdave555
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Re: How quickly does trimix go bad at room temp?

Postby mcdave555 » Sat Jan 04, 2020 7:37 pm

Hi guys used Tri Mix for 3 years and always keep it the fridge, however they say it expired in 30 days on the bottle.
I had a bottle or vile for 4 plus months and \it worked just as good as previous but had to use 2 more bars and it as still good

Agfa13
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Re: How quickly does trimix go bad at room temp?

Postby Agfa13 » Sat Jan 04, 2020 7:46 pm

Hey guys, for me, when I was using Trimix, I would definitely keep it in the fridge. I was told it would last 90 days in fridge.
Got the bright idea to freeze it...nothing happened when I thawed it. Out of I think maybe 7 vials, one went bad.
Ag, 58, Maryland
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