What to do if the injections dont work as well as before

[Ahknaten]

I have this trouble my prostaglandin has gradually diminished in effectiveness.

I asked my urologist and he said a malleable rod implant.

Throughtout my research if a patient has significant penile fibrosis a malleable rod is recommended.

Ive been injecting with prostaglandin E1 for 15 years and penile fibrosis can happen with that line of therapy.

has anyone had a simular experience? any experience with malleable rods?

[oifsps]

I havnt read much about them on here, it could be because they arent used as much perhaps? I dont know, perhaps they are but it seems to be a lot less common than the updated implants. Is there any reason that wasnt a suggestion, or isn t an option in your case?

[dtwarren1942]

Ahknatin, I have been injecting for a little over a year without any problems; however, I would appreciate information on the progression of your fibrosis and whether it was directly related to your injections.

[Muz061]

I'm not sure but wasn't one of the issues with prostoglandin the risk of fibrosis so they use it as one of 3 ingredients in trimix?

[Bluewhippet]

My understanding is the exact opposite; Prostaglandin, otherwise known as PGE-1 or Alprostadil, is less likely to cause fibrosis and priaprism but can cause pain after injection in some men (i am one of the lucky ones not affected). PGE-1 is the sole active ingredient in both Caverject and Edex penile injections. These are the onlt intracavernosal injections available in the UK.

[JimStars]

BlueW,

Yes that is also my understanding. PGE-1 is the least likely to promote fibrosis. But, it must be easy to get mis-informed. I asked my Uro on last visit if I should be concerned about fibrosis and he dismissed it quickly by saying that Trimix ingredient Papaverine helps prevent fibrosis! (Let's state right here that is not the case -- Papaverine contributes MORE to fibrosis -- if you are prone to it -- which most people are not). So, he can write great prescriptions but I won't depend om him for any useful injection info!

J