increasing dosage

[davevulcan]

hello fellow injectors;
It has been almost six months since my doctor prescibed Alprostadil for me. He started me on 20 units of \prostin E1 20 mcg/ml. I have experimented with dosages from 5 units to 28 units with very limited differences. It appears that increasing the amount, over 15 units total, only changes the length of time of the erection with the maximum time length of 1 to 1.5 hours.
Although I am pleased with injecting over any other treatment, I would like to get more than a 80 % erection and get closer to a rock hard one. My insulin needles only go to 30 units (3/10cc) but I found some that go up to 50 units. I am a little confused with the definition of what a unit is, but I am considering of trying to go up to 40 or 50 to see if I can achieve my goal. I was wondering if any member would like to comment on this action before a venture up the scale. It is not possible to contact my urologist right now for his advise.

When my doctor initially injected me I received little instruction and have relied on this forum for most of my information.

Alsofor information: I left a needle of this product out for a couple of weeks (not refrigerated) and when I tried it, there seemed to be very little loss of effectiveness.

Would it be worth my time trying Tri-mix over the Alpostadil?

[thinktank]

I cant help you with advice on your chemical, but I can tell you that 31 gauge diabetic syringes with 5/16 inch needles come in 1ml or 1cc capacity marked at I00 IUs.

I am using such a needle for TRT injections.

Good luck to you man.

Your pharmacy should have those syringes.

[Tigerfan53]

In your quest for that final 20%, I would advise that you have patience and take it slowly, increasing the dose only a little each time – or you might end up taking an unwanted trip to the ER. I’m afraid that you’ll find the duration will increase as you bump the dosage up and if you’re already at 1.5 hours, then you’re already at the top of the scale. Dr. Mulhall says you really shouldn’t stay above penetration hardness for more than 1.5 hours; at 2 hours you’re supposed to take 4, 30mg Sudafed tablets in an attempt to bring it back down.

1 unit = 0.01cc = 0.01ml.
10 units = 0.10cc = 0.10ml.
50 units = 0.50cc = 0.50ml.
100 units = 1.00cc = 1.00ml.

You’ll find Trimix to be less expensive than Alprostadil (aka Caverject). Trimix is a combination of papaverine, phentolamine, and prostaglandin. Prostaglandin is a variant of Alprostadil. it’s different medicine, so if you switch you’ll need to re-figure what dose you’ll need. Trimix is more effective than Alprostadil: about 60% of men get results with Alprostadil, whereas 90% get results from Trimix.

Good Luck -- Tigerfan

[cmetalman]

Im up to 90 units and am hard enough for sex up barely and only last no more then 1/2 hour so will be topping off at 100units then off to a stronger mix...just thinking out loud.

[ohohiakane]

Dave ...
see my simple units explanation in this topic Titled, "compare units with cc's"

Bill

[trimixlover]

been on trimix for 3 yrs...in the last year ive noticed less strength went to urologist who said my dosage is too high already... my dosage is as follows..papverine 30mg...phentolamine 1.5.....pge 1...50 wondering if this is truly high..anyones thoughts??

[NJTransplant]

Be sure you don't confuse dosage with concentration. Dosage is calculated by multiplying concentration (as in mg/cc) by volume injected (as in 25 cc).

[davevulcan]

In your quest for that final 20%, I would advise that you have patience and take it slowly, increasing the dose only a little each time – or you might end up taking an unwanted trip to the ER. I’m afraid that you’ll find the duration will increase as you bump the dosage up and if you’re already at 1.5 hours, then you’re already at the top of the scale. Dr. Mulhall says you really shouldn’t stay above penetration hardness for more than 1.5 hours; at 2 hours you’re supposed to take 4, 30mg Sudafed tablets in an attempt to bring it back down.

1 unit = 0.01cc = 0.01ml.
10 units = 0.10cc = 0.10ml.
50 units = 0.50cc = 0.50ml.
100 units = 1.00cc = 1.00ml.

You’ll find Trimix to be less expensive than Alprostadil (aka Caverject). Trimix is a combination of papaverine, phentolamine, and prostaglandin. Prostaglandin is a variant of Alprostadil. it’s different medicine, so if you switch you’ll need to re-figure what dose you’ll need. Trimix is more effective than Alprostadil: about 60% of men get results with Alprostadil, whereas 90% get results from Trimix.

Good Luck -- Tigerfan

Thanks for the information.
so if I get the calculation right, since I am using 25 units of 20 mcg/ml, I am actually injecting .50ml. Wouldn't that be on the high end of the scale already.

[Bluewhippet]

Hi Dave, I am based in UK and we do not have trimix as an option, so I use Caverject (Alprostadil) and I have done quite a bit of research on its use and the various trials that were done by the manufacturers Pfizer. From your description of 20 mcg in each ml I do not think you are using a particularly large dose. The important thing is not really the volume you are injecting but rather what quantity of Alprostadil is in each injection. With your concentration, injecting 1 ml (100 units on an insulin syringe) would give you 20 mcg (micrograms) of Alprostadil. People's reaction to Alprostadil varies widely - some people only need a small dose others much more. In the original manufacturers trials, I understand that the average dose men ended up on when they had gradually built up was 21.7 mcg for good results lasting not more than 1 hour. So your injection if you used all of the 1 ml (100 units) would be just under the average found in the trial. I undertand that 40 mcg is usually the largest dose recommended which is why the largest Caverject vial holds 40 mcg (the largest dual-chamber syringes they sell hold 20 mcg). I have read elsewhere that some people have used up to 60 mcg but this is unuual. Whilst priapism (overlong erection) can be a problem with Alprostadil it is much less prevalent than with trimix and scarring is also less likely.
Turning to my own experience, although I get some response from as lttle as 5 mcg of Caverject I am not firm enough for intercourse. After gradually increasing the dose under the supervision of my specialist, I have found that I need between 20 and 30 mcg. A 20 mcg dose is fully firm but only lasts about 20 mins - not long enough for me. 25 mcg gives me about 45 mins and 30 mcg just over an hour fully firm, although I am chubby for some time afterwards. Of course many people will need much less. My ED is, I assume, the result of Type 2 diabetes (treated by pills) which I have had for some 15 years. Originally Viagra worked well but gradually became less effective and I started on injections 12 months ago.
In summary, everyone is different but so far I do not think you have been using a particularly large dose.

[davevulcan]

thanks Bluewippet
I am Canadian so the Alprostadil seems to be the drug of choice. It is also very inexpensive, 6ml for $65, and since I am not nearly as active sexually as I once was, the product sadly expires before I use it up. The expirey date is 3 months.
Doing the math now, I am currently using .25 ml - (25 units on my insulin needle) - of the 20 mcg/ml Alprostadil which would work out to 5 micrograms of the Alprostadil.
Am I correct thinking if I try .40 ml, I would be using 8 mcgs ?
It is quite comfusing with all the different conversions or maybe I am just too thick in the head. My big head unfortunately not my little head.
thanks again for everyone who has graciously responded