Soon after my divorce I experienced a sudden onset of ED. Could have been mental or an accumulation of things, I don’t know. I was 43, healthy but stressed and depressed. Pills worked great but after rectal cancer radiation and surgery the ED complete. This is my story with Trimix:
February 2017 after 2 years I’d struggle I got on Trimix 40/30/2 and 3-5 units witks great.
April 2017 switched to Autoject and 1/2 inch 28 gauge needle set at 5/16 length which made a huge difference in predictability and less pain.
October 2017 switched to 5/16 30 gauge needles which was a disaster with unpredictable results and bruises. Needle too thin for Autiject.
May 2018 tried manual injection with 5/16 30 gauge needle. Was a little more pain than Autoject but suppose it’s less trauma to the tissues. Had to push it in all the way and more but once the resistance was gone it went in easy.
Will try this for a while and see where it goes. Otherwise I’ll just go back to Auotoject.
We have to try new things to figure this out and get the best long term results possible.
All the best!
My Injection Evolution!
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Re: My Injection Evolution!
I am a rookie myself using autoject with 30. G. 5/16. Guess because thats all the pharmacy has ajways ask for 29. 1/2 but they never have any different
edex and tri mix 45/1/27 26 units
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- Location: Tampa Bay, Florida USA
Re: My Injection Evolution!
I'm a rookie as well. I had one fail so far that didn't go over too well. My initial trimix injection was done in the doctor's office with my wife and she took the reins and did the first injection as well as the first few. About my 5th trimix injection the wife stuck the needle in me and forgot to pull the plunger cap off and decided to pull the needle back out instead of pulling the plunger cap off and I lost my cool which didn't go over too well. I ended up injecting myself waiting 20 minutes and it didn't work(frustrated) and injected myself again which did work but I felt like my dick was a pin cushion at that point. The initial 10 30 guage 5/16" needles I received with my trimix prescription were generic store-brand that didn't seem that sharp and were harder to puncture into the corpus cavernosa to me. This also seemed to make it slightly sore at the injection site after the injection. I asked the question here on the forum if there was any brands of needles that were better than others and I believe Larry mentioned that BD was the gold standard. I took his advice and got a big box of a hundred from Walmart of BD 31 gauge 5/16 in needles for about 30 bucks. I'm happy with the BD brand needles and they seem to be much shaper and go through the tissue with ease. THANK YOU LARRY! I'm very frugal and love to save money but this is one area where I didn't feel like I wanted to skip out on. One technique that my urologist showed us that I like and have not seen anywhere else... when you go to inject into your flaccid penis to wrap or bend your dick around your finger in such a manner that tightens the skin where you want to inject. This technique seems to support the tissue while you're injecting into it . Perhaps a better way to describe it is to weave your dick between your pointer finger middle finger and ring finger to inject into it. I slowly stick the needle in to where I can feel it puncturing into the corpus cavernosa and bury that 5/16" needle to the hilt before pressing down the plunger.
My two cents...
My two cents...
Age 47. Married in 2005. Tampa Bay Florida USA. Got ED 24 years ago from being paralyzed. Made a 90% recovery. See profile for more info...
Re: My Injection Evolution!
Bob1974 wrote:I'm a rookie as well. I had one fail so far that didn't go over too well. My initial trimix injection was done in the doctor's office with my wife and she took the reins and did the first injection as well as the first few. About my 5th trimix injection the wife stuck the needle in me and forgot to pull the plunger cap off and decided to pull the needle back out instead of pulling the plunger cap off and I lost my cool which didn't go over too well. I ended up injecting myself waiting 20 minutes and it didn't work(frustrated) and injected myself again which did work but I felt like my dick was a pin cushion at that point. The initial 10 30 guage 5/16" needles I received with my trimix prescription were generic store-brand that didn't seem that sharp and were harder to puncture into the corpus cavernosa to me. This also seemed to make it slightly sore at the injection site after the injection. I asked the question here on the forum if there was any brands of needles that were better than others and I believe Larry mentioned that BD was the gold standard. I took his advice and got a big box of a hundred from Walmart of BD 31 gauge 5/16 in needles for about 30 bucks. I'm happy with the BD brand needles and they seem to be much shaper and go through the tissue with ease. THANK YOU LARRY! I'm very frugal and love to save money but this is one area where I didn't feel like I wanted to skip out on. One technique that my urologist showed us that I like and have not seen anywhere else... when you go to inject into your flaccid penis to wrap or bend your dick around your finger in such a manner that tightens the skin where you want to inject. This technique seems to support the tissue while you're injecting into it . Perhaps a better way to describe it is to weave your dick between your pointer finger middle finger and ring finger to inject into it. I slowly stick the needle in to where I can feel it puncturing into the corpus cavernosa and bury that 5/16" needle to the hilt before pressing down the plunger.
My two cents...
You're welcome Bob.

Larry
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- Posts: 425
- Joined: Tue Mar 27, 2012 6:03 pm
- Location: Boise, ID
Re: My Injection Evolution!
FWIW, when I was injecting the BD needles were the best I found. The least pain comes from the smallest diameter needles, but they need to be good quality to penetrate well.
I used both 5/16" and 1/2" lengths. The 1/2" seemed to be easier to use and make sure they worked every time. At one point I got re-educated by a nurse in my uro's office. She said that 5/16" was too small and I should always go longer. I never had any trouble with the 1/2" but I did with the 5/16". YMMV.
Good luck with your progress. I hope you have a ton of success.
Quincy
I used both 5/16" and 1/2" lengths. The 1/2" seemed to be easier to use and make sure they worked every time. At one point I got re-educated by a nurse in my uro's office. She said that 5/16" was too small and I should always go longer. I never had any trouble with the 1/2" but I did with the 5/16". YMMV.
Good luck with your progress. I hope you have a ton of success.
Quincy
71, Boise area, Married
ED from type 2 diabetes and PCa radiation.
AMS LGX surgery 6/5/18 with Edward Karpman in Silicon Valley, 18cm+3RTE
ED from type 2 diabetes and PCa radiation.
AMS LGX surgery 6/5/18 with Edward Karpman in Silicon Valley, 18cm+3RTE
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- Posts: 170
- Joined: Fri Apr 06, 2018 8:37 am
- Location: Tampa Bay, Florida USA
Re: My Injection Evolution!
Another thought that came to me since my post above was that using good quality needles is probably also important to minimize chances of getting scar tissue to minimize the chances of creating Peyronie's?
Age 47. Married in 2005. Tampa Bay Florida USA. Got ED 24 years ago from being paralyzed. Made a 90% recovery. See profile for more info...
Re: My Injection Evolution!
newtoed wrote:Soon after my divorce I experienced a sudden onset of ED. Could have been mental or an accumulation of things, I don’t know. I was 43, healthy but stressed and depressed. Pills worked great but after rectal cancer radiation and surgery the ED complete. This is my story with Trimix:
February 2017 after 2 years I’d struggle I got on Trimix 40/30/2 and 3-5 units witks great.
April 2017 switched to Autoject and 1/2 inch 28 gauge needle set at 5/16 length which made a huge difference in predictability and less pain.
October 2017 switched to 5/16 30 gauge needles which was a disaster with unpredictable results and bruises. Needle too thin for Autiject.
May 2018 tried manual injection with 5/16 30 gauge needle. Was a little more pain than Autoject but suppose it’s less trauma to the tissues. Had to push it in all the way and more but once the resistance was gone it went in easy.
Will try this for a while and see where it goes. Otherwise I’ll just go back to Auotoject.
We have to try new things to figure this out and get the best long term results possible.
All the best!
Unless you are giving a venous injection (and you're not) you are suppose to use the needle like a dart. That may make it easier to get it in with out so much difficulty and pain.

Larry
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- Posts: 420
- Joined: Sun Jul 20, 2014 7:28 pm
Re: My Injection Evolution!
I tried both thick and thin needles, manual and Autoject. 1/2” 29gauge meddle set at 5/16” length in Autoject works best for me: quick, absolutely pain free, 100% predictable and minimizes needle phobia. To me it’s perfect.
Age 54, Single, Los Angeles. Stage 2 rectal cancer in 2013. Radiation, surgery, chemo. In remission for 5 years. Some ED before cancer, complete since. 2-3 units of Trimix 40/30/2 2-3 times a week since Feb/2017 with great success!
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Re: My Injection Evolution!
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Last edited by bldoink on Mon Jul 21, 2025 6:33 pm, edited 1 time in total.
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Re: My Injection Evolution!
Brands do matter. I switched to Exces syringes I had from the past and not happy with them. Plunger is lot harder to move. Sometimes I had some Trimix left in the syringe after I removed it from the Autoject. This is not good especially since I use only 3 units which is a drop. Also the the whole 1/2 inch of the Excess needle sticks out of the Autoject even though I set it at 5/16 which increases the chance of urethra penetration. Exces doesn’t seem to be compatible with Autoject.
I love Easy Touch brand ($15/100 syringes). It has 3 beveled needles which makes them sharper and I do notice the difference. The plug moves easier so no chance to get stock.
All the best.
I love Easy Touch brand ($15/100 syringes). It has 3 beveled needles which makes them sharper and I do notice the difference. The plug moves easier so no chance to get stock.
All the best.
Age 54, Single, Los Angeles. Stage 2 rectal cancer in 2013. Radiation, surgery, chemo. In remission for 5 years. Some ED before cancer, complete since. 2-3 units of Trimix 40/30/2 2-3 times a week since Feb/2017 with great success!
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