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So I've been injecting Tri-Mix for a few months now, in various mixes and doses trying to find the optimum. Per sig block I previously used Mono-Mix Caverject (at ~35mcg). It burned pretty good to the point of inhibiting ejaculation but it lasted well for wifey. I got a batch of Tri-Mix that caused a real misfire, see the "allergy?" thread.

As a result, I've undergone some sensitivity testing of the Tri-Mix components. I'll write the results in that thread when wrapped up.

BUT as part of it, after some scratch and "challenge" tests into the unit, the allergist suggested injecting some of the offensive Tri-Mix (a 30-1-20) subcutaneously 1/8" deep in the arm at 0.1ml, and also with some new home-made mix, similar strength.

It was like a bee sting. The welt was 3/4" dia in 10 minutes and red and raised and itched and burned. After 8 hours it looks like my arm was hit with a ball peen hammer and the red-blue "bruised" area was 1 1/2" dia. The fresh mix was not as bad, immediately a 3/8" raised welt, and after 5 hours a 1/2" pink "bruise". I have photos. Much worse than a shot or blood draw.

It makes me wonder what this does over time to the caverenosa?? Some of you might try it to see what happens to you at maybe half your normal dose. Can anyone explain this reaction?

PS: added photos - the injections were about 5 1/2 hours apart, the first the initial Tri-Mix. As usual the appearance was more striking in person versus the photo. They caused my wife to gasp wondering what willy was being subjected to.

Bee stings do contain prostaglandins, it helps to dilate blood vessels and move the venom into the body.

Both look like a few days old bruise today, one 1 1/4" dia and darker and the other 1/2" and lighter. One definitely saw more trauma than the other.

Just TOL, perhaps the answer is that the cavernosa is designed for that "flex" while the arm tissue is not? Getting a boner in your flesh may not be the same, leading to a bruise? I just know that higher doses of PGE, say 30mcg+ is really a pain.

Scratch that photo above, more on it later.

The forearm injection test of original and new Tri-Mix yielded a faint bruise 2 days later, 7/9 photo attached. The one on the right (below), the 2nd, the original Tri-Mix, is still quite large and visible today the 12th, five days later, with a 3/4" normal spot and a dark bullseye around that abut 1/2". (Note that the photos do not do the image justice.)

So Tri-Mix leaves a healthy "hematomoa" (bruise) when injected into skin. See next.

On 7/9, I injected 1.5mg of papavarine subdurally, and 2.0mcg of alprostadil (PGE-1). This was the same dose of PGE as in the two earlier Tri-Mix injections and the papavarine was in the middle.

There was absolutely no reaction from the papavarine. Period.

OTOH, the pure alprostadil was pretty catastrophic. The arm hurt/ached like a red wasp sting from the elbow to the hand for hours. The initial welt was well defined and purple, not red. It just got bigger Day 1, 7/9. By Day 2 the welt had subsided but the bruise grew to 1 1/2"dia and dark. Today, Day 3 is is still quite visible and dark.

It seems that the pure alprostadil/PGE reaction (a chemically induced hemorrhage) on skin is more severe than when ameliorated by papavarine and/or phentolomine.

Key: What impact this has on the cavernosa I know not.

From these 4 tests, it seems you might have a bad reaction if you missed the mark in depth and did not get the full load into the cavernosa. It just may wreak havoc with your penis as possibly happened to me (see other thread).

Summary:
ArmT#1 - Bad. Orig mix: papavarine = 3.0mg, phentolomine = 0.10mg, PGE = 2.0mcg (3xT#2 phent & pap)
ArmT#2 - Fair. New mix: papavarine = 1.0mg, phentolomine = 0.03mg, PGE = 2.0mcg
ArmT#3 - None. papavarine = 1.5mg
ArmT#4 – Very bad. PGE = 2.0mcg
I may yet try pure phentolomine.

Note: Photos in reverse order.