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My experience with injecting near the "tip" as you call it has not been good. I was injecting just below the Glans. For whatever reason my penis developed "lumps" that took weeks to subside. I did not see any advantage or difference in the effect of the medication but never experienced lumps when injecting lower down the shaft.

Unfortunately, there is not a hard and fast rule on the very best spot to inject. Everyone has to experiment and determine what is best for them. I started out close to the base and eventually moved forward to nearer the head, where I am getting excellent results. For someone else closer to the base might work best. The one frustrating thing about Trimix is that it doesn't work the same for everyone, and that forces all of us to constantly tinker and experiment to find the best results for us.

Good luck!

Unfortunately, there is not a hard and fast rule on the very best spot to inject.

I'll 2nd that. I'm still new to injecting and experimenting with just Alpostadil. The 1st 2 injections were 1" from the base I had a few hour burn (I seem to be sensitive to Alprostadil) with dismal results. The last 2 injections I tried below the glans, Right then Left. No burn but no joy. It was as if I had not injected at all. Nada. Many have reported great results with Monomix/Prostaglandin/Alprostadil . Not me. So there's another variable.

I seem to get better results when I go "lower" toward the base. And I'm injecting half the fluid on each side because so far I can't find the communication between the two sides across the septum. (Yea, yipes.) I've had well over 100 pokes in almost two years.

I've been trying to figure out which way the blood flow is in the cavernosa; it seems radial. Diagrams (Wiki & elsewhere) seem to show a cavernosal artery running somewhat down the middle of each cavernosa and veins underneath. If you hit that is it OK and does the chemical get distributed better with the blood inflow?? Where it goes to the exit veins is not known by me. The descriptions I've seen so far are pretty basic. The idea would be to sweep the chemical around as much as possible before exiting. A related question also is how flaccid versus plumped to inject for the same reason (besides a bigger target). What condition would allow the most chemical contact and utilization. Trial and error works over dozens to hundreds of shots but understanding anatomy might help also. Some of these factors may make the elusive difference for some of a hit versus a miss. I have a lot of questions for my next Uro checkup. I may have raised more questions than answers here but that's where I'm at.

Just the other night, I developed a lump and a lean to the right after injecting on the right side about halfway up the shaft. It also wasn't quite as effective. The needle needed a little extra push and developed a dark spot where it poked. Not a good experience.

Two days later, the lump and curve are starting to subside. I normally inject on the right side, as I don't inject very often. But I definitely will inject on the left next time, perhaps a little more toward the base.

Thoughts?

I have been using Trinidad for almost two years now. I noticed that when I inject on the right side and closer to the tip I get a little bump right behind the glans the goes away after like a half an hour. I have no idea what this is because it’s not at the injection site. I don’t have this on the left side. I also don’t have it when I inject closer to the base.

Go figure!

That same bump is now going away after 3 1/2 days.

For practice, I injected today with what little I had from a previous weaker mix. Turns out there was only 10 units in there. I was extra careful where I injected (left side this time and just below middle of shaft closer to base), and made sure there was no air or bubbles in syringe. I didn't expect much, but that little "drop" was one of my better results! It only last about an hour and a half, but that's plenty of time.

So, where and how careful you inject may be more important than anything else! Lesson learned.