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I have been using EDEX 20mcg for many years with success. In the past year I have noticed that my erections were becoming less firm and not maintained as long. In the beginning I would get rock hard erections and maintain penetrable firmness for a couple of hours, sometimes 3. Now, the injection wasn't holding the erection more than 20-30 minutes. So after foreplay that we love, I was getting unable to penetrate. My doctor suspects that I may have built some tolerance to the monomix and has put me on Trimix. Because of the suspected tolerance, he has passed the usual initial mix of 30 pap - 1 phen - 10 pge, and prescribed me 30pap - 3phen - 40pge. The prescribed dosage is .2ml, with instructions to inject .1ml the first time.

I was wondering if anyone else has made the jump from alprostadil alone to the mid-range dose of Trimix as I have, and what was your experience? Is the .1ml the first time appropriate, or should I drop to .05ml because it is much stronger than I am used to? Any suggestions and/or advise would be appreciated.

Also, I did order the injectable Phenylephrine in case of prolonged erections due to the stronger mix.

I used Edex too, the main reason i switched to trimix was that Edex made my penis ache. You need a small amount of Trimix.
I would get hard in 10 mins, stay hard for 2 plus hours.
I have had to increase the dosage over the years.
but now I am at the point like you where it only last for 20 -30 mins.
I did try Quad Mix but that also made my penis ache.
When i first started on injections my uro told me i would most likely need an implant, and that is what i am looking into now.
Good luck with the Trimix, increase the dosage little by little, it works good.