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On Trimix started at low dose of 0.3ml and went up 1 unit till had some result then went up 1/2 unit hoping to get the right dosage. About the only thing I have is some puffiness not rigid enough to call it a hard on , still can get some penetration . Started to see something but now with up to 0.90ml/90units and feels like my penis is on fire/burning with still no hard on. Im 54 Diabetic, tried all the pills, muse and now trimix. Would really like to have a hard on,talked to pharmacist at compound center and he had said that there is different formulas that they can do but my Dr wants me if I get to 1 unit and still nothing to come in and look at some electroid stimulate treatment??? Here's my prescription they started me with
Papaverine hcl 30mg/ml
Phentolamine mesylate 0.5 mg/ll
Prostaglandin (e1) 10 mcg/ml

Looking for some input, thanks!

I'd tell the doctor to skip the electroid treatment and prescribe a stronger mix. I'm guessing that electroid treatment is another name for shockwave. It's been tried by several guys here on FT and at best the results are very temporary. I ended up getting an implant after trying 100 units of the strongest mix failed. BTW, the burn eased somewhat after subsequent use.

That is a pretty weak Trimix blend. Have your urologist write a new script and skip a couple of the intermediate strengths. (Example: if you are getting little results with 90units of this strength, it’s pointless to make a minor adjustment to the mix. He/She should be bold.)

If you max out on Trimix there is still Quadmix (a strong Trimix with atropine added as the 4th medication). There may be more exotic possibilities but Quadmix is usually where most men hit the endpoint before they need to consider other options to get their erection.

A medical VED (vacuum pump) with a construction ring to keep the erection, or a penile implant would usually be the next step if injections don’t work.

Talked to compound pharmacist today and agrees with you guys about low dose of trimix, said it was a standard dosage. Said he would talk to Dr about different formula, Trimix 1 maybe Quadmix. Waiting to hear back from Dr. The Pharmacist said he could lower the Prostaglandin since that's what causes the pain/burning feeling, but worried it might not be as effective since that's what gets things going from what he Said! Not sure what I should be stepping up to now???

Rdd66dog,

Yes consider a stronger mix. Also, if you haven't yet try some novelty cock rings with the injection. There are numerous posts on the topic. Some guys find it helps the injections a fair bit. Are you confident of your injection technique?

It’s good you are talking with the pharmacist and MD.
It might take a couple tries to find a mix that works for you.


The great thing is that the components of Trimix (or quadmix) can be adjusted independently. So they could go up on the papaverine and phentolamine a LOT and the prostaglandin a bit to see if you get a better effect without as much ache.

I was on a strong TriMix before switching to QuadMix. With the addition of the atropine (in the quadmix) I am using a lower volume of the drug overall (25units now instead of 50units of the Trimix) so the amount of prostaglandins I’m getting is lower and I have less ache as a result.

But everyone is different and you’ll need to be patient as you and your healthcare providers zero in on the best mix/dose for you.

Rdd66dog wrote:On Trimix started at low dose of 0.3ml and went up 1 unit till had some result then went up 1/2 unit hoping to get the right dosage. About the only thing I have is some puffiness not rigid enough to call it a hard on , still can get some penetration . Started to see something but now with up to 0.90ml/90units and feels like my penis is on fire/burning with still no hard on. Im 54 Diabetic, tried all the pills, muse and now trimix. Would really like to have a hard on,talked to pharmacist at compound center and he had said that there is different formulas that they can do but my Dr wants me if I get to 1 unit and still nothing to come in and look at some electroid stimulate treatment??? Here's my prescription they started me with
Papaverine hcl 30mg/ml
Phentolamine mesylate 0.5 mg/ll
Prostaglandin (e1) 10 mcg/ml

Looking for some input, thanks!

Highly recommend you team up with a very competent compounding pharmacy and, as seems may be necessary here, have the pharmacist school your physician on these drugs/blends. Do not assume your physician, regardless their credentials, is comfortable/competent with TriMix. Also do not assume your pharmacist knows enough. Many don't.

Pharmacies and the physician for that matter are not created equally...they will have wildly varying bases of knowledge about injecting and they will show their uncertainties and biases along the way. That's not necessarily a bad thing. Just understand that, like anything else, there are people out there who have much deeper knowledge and confidence and assertiveness with this than others do, and you should seek those people out early on before you get frustrated.

I implanted last year but had a 9 year run of a lot of different formulations (drug potencies) and a lot of different volumes injected. Your starter dose is probably ok for a starter dose...generally...but apparently not quite right to get you the effects you clearly desire. Consider the mixes I was on over that 9 year span:

Papaverine / Phentolamine / Prostaglandin (Alprostadil)
mix #5: 30mg 1mg 10 mcg's - starter
mix #8: 30mg 2mg 20 mcg's
mix #9: 30mg 4mg 40 mcg's
mix #13: 30mg 6mg 60 mcg's
mix #16: 30mg 6mg 100 mcg's

My compounding pharmacy blended 16 varying mixes. You have options.

Assuming you are injecting properly, into a viable tissue space, with a properly blended and refrigerated and fresh mix, you should likely have some success. It takes some time to work things out and to titrate to effect, though.

You may not have a fundamentally different experience moving your injected volume up one-tenth of a milliliter from 0.9ml to 1.0ml. But you should also probably methodically try moving up until you get to a full syringe injected (usually 1.0ml) before moving on to another potency mix. It was true for me in the early going that moving a volume 5 or 10 units often yielded a surprisingly different response.

I was on my starter mix for something like 4.5 years or so. I started at 20-25 units and it took me that many years to top out my starter mix at a full syringe, meaning I then moved on to the next mix on that above list (and, then, at an injected volume which made sense and did not in fact slide me backwards).

I moved steadily through those above 4 increasingly potent mixes over the next 4+ years. They eventually topped out and I understood implantation was on my horizon. There is a much more detailed narrative to how this all went for me, and your mileage and experiences will vary, certainly, based on your physiology, your healthcare providers' knowledge and approach, and (no small thing) your individual goals. Titrated assertively, TriMix can deliver hardons which do things you will probably not believe possible. So you just need patience, perseverance, and clinicians supporting you who seriously know their shit. Cut bait with anyone who does not aggressively get you to where you want to go.

If you find you would like to chat more, feel free to message me. Always happy to support anyone who is starting off or struggling with TriMix. I had a really great experience with TriMix overall and learned a hell of a lot along the way. Happy to share with you my pharmacy info etc, whatever you need.

Good luck.

A good post Stephen.

Appreciate the responses, definitely more knowledge and help here then ever got from Drs !!!
Got a call from compound pharmacist and Dr called in Quad mix
30mg-2mg-20mcg-0.2 mg
Start at 30 units
Worried about the burn since they doubled Prostaglandin
And they are so backed up no prescription filled till the 29th!
Trying 1mg vial with 3 doses but only lasts 3 days in fridge and 45 days freezer ,but can't just take out 1 dose and refreeze???
Kind of pricey ,but worth it for an actual hard on!

Rdd66dog wrote:.....but can't just take out 1 dose and refreeze???.....

Why not? Does it say you can't? I think most guys freeze and refreeze their mix. I'm only on mono-mix but I refreeze.

But seriously, if you haven't tried adding novelty cock rings to your program, you should give it a try.