I've been using Trimix for a few months - T105 (PA 30mg/PH 1mg/PG 10mg) - generally 10 units with 100mg of Sildenafil 60-90 minutes prior or 20 units without the Sildenafil. Only had 1 or 2 failures at the start but have since had fairly consistent and predictable - often spectacular - results at the aforementioned dosages. Have had some of the best and most confident sex I've ever had in my lifetime of ED troubles. No Prostaglandin ache. No noticeable scar tissue buildup. However, what I'm reading about scarring/fibrosis with long term Trimix and Papaverine usage has me wanting to try a mono of PGE1/Alprostadil. I still have about 10 syringes of Trimix remaining and was thinking this would be a good time to order and experiment with the Alprostadil. If it doesn't produce a similar result or the ache is too much to handle, I'll just re-up my Trimix prescription. This brings me to some questions though...
The Alprostadil I'm looking to order from Defy is a lyophilized 100mcg/10ml vial. What dosage should I start at given the results I've had thus far with the Trimix at a PG of 10mg? I know to inject more slower and already do that with the Trimix.
Has anyone switched from one to the other like this or alternate between the injectable options?
Trying Monomix of Prostaglandin E1 After Trimix
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Trying Monomix of Prostaglandin E1 After Trimix
48 years old, ED since teens, 25-50mg of Sildenafil worked for 20 years but now require 100-200mg of Sildenafil - sometimes split into 25-50mg every 4 hours - + daily Tadalafil at 5-20mg. Have had P Shot, Gainswave, TRT, and now on to Trimix injections.
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Re: Trying Monomix of Prostaglandin E1 After Trimix
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Last edited by bldoink on Thu Jul 31, 2025 10:25 pm, edited 1 time in total.
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Re: Trying Monomix of Prostaglandin E1 After Trimix
You were who I was hoping would reply, Bldoink
Thank you!
Yes, I would have to reconstitute it with bacteriostatic water. I imagine they'll send me instructions as to how much but I'm not 100% sure, so your estimated reconstitution makes sense. So does your math but math also isn't my strongpoint which is why I came here looking for some guidance. I was going to start much lower - like maybe 10 units without stacking a PDE5 inhibitor just to see the effect and either add Sildenafil to that the next time or move up. Similar to how I approached the Trimix. Plus I imagine the prescribing doctor will recommend a starting dose, too. Appreciate your input!

Yes, I would have to reconstitute it with bacteriostatic water. I imagine they'll send me instructions as to how much but I'm not 100% sure, so your estimated reconstitution makes sense. So does your math but math also isn't my strongpoint which is why I came here looking for some guidance. I was going to start much lower - like maybe 10 units without stacking a PDE5 inhibitor just to see the effect and either add Sildenafil to that the next time or move up. Similar to how I approached the Trimix. Plus I imagine the prescribing doctor will recommend a starting dose, too. Appreciate your input!
48 years old, ED since teens, 25-50mg of Sildenafil worked for 20 years but now require 100-200mg of Sildenafil - sometimes split into 25-50mg every 4 hours - + daily Tadalafil at 5-20mg. Have had P Shot, Gainswave, TRT, and now on to Trimix injections.
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Re: Trying Monomix of Prostaglandin E1 After Trimix
Bdloink -- is that the way you get yours -- dry? I have seen it on Olympia's list but not sure what form they sell it in.
I do applaud your interest in switching, Cozpgh -- I am one of the former Trimix users who suffered significant damage from the Papaverine. Though I will hasten to point out that many if not most Trimix users do not suffer damage.
I do applaud your interest in switching, Cozpgh -- I am one of the former Trimix users who suffered significant damage from the Papaverine. Though I will hasten to point out that many if not most Trimix users do not suffer damage.
75, used pills, injections -- all lost effectiveness. Titan implanted by Eid in Feb '22.
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Re: Trying Monomix of Prostaglandin E1 After Trimix
Thanks Crazyjoe. Yeah, stories like yours have me thinking I should maybe at least attempt the switch despite being pleased with the Trimix results. At 48, I'd ideally like to get 10 to 15 years out of the injections before considering an implant. I know there's no guarantee they'll even be effective for that long but figure I should do what I can to minimize potential scarring and other damage pre implant. We'll see if it's just as effective and for how long.
48 years old, ED since teens, 25-50mg of Sildenafil worked for 20 years but now require 100-200mg of Sildenafil - sometimes split into 25-50mg every 4 hours - + daily Tadalafil at 5-20mg. Have had P Shot, Gainswave, TRT, and now on to Trimix injections.
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- Location: Fl.
Re: Trying Monomix of Prostaglandin E1 After Trimix
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Last edited by bldoink on Thu Jul 31, 2025 10:26 pm, edited 1 time in total.
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Re: Trying Monomix of Prostaglandin E1 After Trimix
Cozpgh wrote:Thanks Crazyjoe. Yeah, stories like yours have me thinking I should maybe at least attempt the switch despite being pleased with the Trimix results. At 48, I'd ideally like to get 10 to 15 years out of the injections before considering an implant. I know there's no guarantee they'll even be effective for that long but figure I should do what I can to minimize potential scarring and other damage pre implant. We'll see if it's just as effective and for how long.
I am in the same boat! I've been using Trimix for about half a year and have been thinking of switching to monomix due to scarring and other issues. Hope you can keep us up to date on how your switch to monomix goes. I am deeply interested in hearing this.
Last edited by dxchase70 on Sun Mar 06, 2022 11:14 am, edited 1 time in total.
51 yo in NYC. Viagra no longer reliable after 15 years of use. I have just started trying Trimix injections (July 2021). Papaverine: 18mg, Phentolamine: 0.6mg, Prostaglandin: 5.88ug
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Re: Trying Monomix of Prostaglandin E1 After Trimix
I would think you guys would prefer to get it in liquid form, no? I could check my sources to find some if you want. Bdloink, does Defy ship out of state?
75, used pills, injections -- all lost effectiveness. Titan implanted by Eid in Feb '22.
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Re: Trying Monomix of Prostaglandin E1 After Trimix
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Last edited by bldoink on Thu Jul 31, 2025 10:26 pm, edited 1 time in total.
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Re: Trying Monomix of Prostaglandin E1 After Trimix
Ok I will check my past sources who ship out of state and get back with you tomorrow.
75, used pills, injections -- all lost effectiveness. Titan implanted by Eid in Feb '22.
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