I am just now starting Trimix injections. I have had 3 so far and have not found my correct dosage yet. Prior to starting this I was taking 20 MG daily Tadalafil for BPH (one half in the morning and one half at night). This worked very well for my BPH. I am wondering if at this point, maybe 10 MG daily would be enough for my BPH. I have read a few messages where guys said they combined Cialis and Trimix. I have also read online and was told by my urologist, it’s not a good idea to mix them. Course my urologist also said not to take even 10 mg of Tadalafil daily.
I am considering starting my Tadalafil back, but only 10 mg a day to try to get my BPH under control again. At the same time, I am thinking maybe start back over at .05 ML for Trimix. I think my formula is a rather weak formula? This is my formula: TRIPLE MIX INJ (IJPC) 15MG/0.5MG/10MCG/ML. My urologist said to start at .20 ML. Based on recommendations from others, I started at .05 ML. My plan was once I found my Trimix injection to stop Tadalafil for 3 days and then inject. But if it is possible and safe, I would rather continue Tadalafil daily and inject Trimix as needed (Maybe a lower dose of Trimix because the Tadalafil will still be in my system)? I was not prescribed the antidote, but I do have 30 MG Psudoephedrine. So if that does not work, I guess I will be going to the ER if it becomes necessary? I would really like to avoid that though ……
If anyone has tried combining the two. What dose of Tadalafil were you using and what dose of Trimix were you using? Did you use a lower dose of Trimix because the Tadalafil was still in your system? Did the combination work better for you? Did it cause priapism? I am wondering if I get back on Tadalafil (maybe 10mg instead of 20mg) and start over at .05 ML of Trimix, then maybe I could find my trimix dosage and not have to worry about stopping Tadalafil on days that I inject.
Any thoughts or experience you could share would be appreciated …
Thank you
Trimix and Tadalafil Combination - good idea or bad idea?
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Trimix and Tadalafil Combination - good idea or bad idea?
Still figuring out my Trimix dose and formula, which has now become Quadmix. The Quadmix is the same as my Trimix formula, but ads Atropine and now is 30MG/1 MG/20MCG/.1MCG/ML.
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Re: Trimix and Tadalafil Combination - good idea or bad idea?
My trimix formula is a step up from yours. I use 5mg tadalafil daily that was prescribed by the same uro. He wanted to start me on 30 units but I convinced him to do half for the first injection and that was too strong. I have now titrated down to using 5 units. I believe the daily regimen allows me to use less trimix than needed. I inject twice a week now have plenty of erections that last 4-5 hours sometimes. They are never painful so I know I’m no where near a priapism. Trimix just works well for me. I had heard that viagra and cialis were not to be taken together but this same uro had me on that combo prior to injections but that was when I used them on demand.
50+ yrs old. married 25+ years. hypothyroid, on TRT. 10+ years ED, viagra, cialis now 50% ineffective. now on trimix 2MG phentolamine/30MG papaverine/20MCG alprostadil
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Re: Trimix and Tadalafil Combination - good idea or bad idea?
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Last edited by bldoink on Wed Aug 06, 2025 12:37 am, edited 2 times in total.
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Re: Trimix and Tadalafil Combination - good idea or bad idea?
Thank you ….. Once I find my correct dosage. I think I will start back on 10 mg daily Tadalafil to see if that will help my BPH. If not, I will go back to my daily 20 mg Tadalafil. Once I start Tadalafil back, should I drop my Trimix dose in half to start or start back over at say .05 ML?
Still figuring out my Trimix dose and formula, which has now become Quadmix. The Quadmix is the same as my Trimix formula, but ads Atropine and now is 30MG/1 MG/20MCG/.1MCG/ML.
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Re: Trimix and Tadalafil Combination - good idea or bad idea?
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Last edited by bldoink on Wed Aug 06, 2025 12:37 am, edited 1 time in total.
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Re: Trimix and Tadalafil Combination - good idea or bad idea?
Thank you ….. I would expect my urologist to say not to mix them. But I will have a new urologist after the end of the month and it might be worth talking to him about it.
Still figuring out my Trimix dose and formula, which has now become Quadmix. The Quadmix is the same as my Trimix formula, but ads Atropine and now is 30MG/1 MG/20MCG/.1MCG/ML.
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Re: Trimix and Tadalafil Combination - good idea or bad idea?
Like others have said, I am not a doctor and can only give you my own experience with taking Tadalafil and Trimix together. First off my Tadalafil dose is much lower than yours, more like 5mgs per day for BPH. Secondly, my Trimix strength is much stronger than yours ( PGE 100 PHE 3 PAP 30) and I take anywhere between 25-30 units. I can lower the dosage (20 units) when my Trimix is new right after the script is filled. I have never had an issue with priapism and I've been injecting over 10 years and been on the Tadalafil a good 5+ years. I will also take a 100mgs of Viagra about an hour before injecting...and still never had a problem. If I do get a dull ache after sex, I place a frozen bag of peas on my crotch after the woman I see leaves my place.
The bottom line is you have to kind of experiment with what works best for you...but I would lean to the conservative side.. Everybody is different and your responses to the mixing the Trimix with Tadalafil may be very different than mine. I would also discuss it with your URO guy. Having a close friend who is a retired Doc, he has told me physicians are trained to error on the side of caution...and no Doc is looking to be sued for giving off the road advice on these things. I often have said on this forum, in all the years I've been on Trimix and on this forum I've never had an erection lasting longer than 1 hour. IDK if guys on here exaggerate, or my penile arteries are so clogged that it's impossible for me to have such a long lasting erection...plus I do have some venous leakage..I wear a cock ring to help that too...Welcome to the wonderful world of Trimix where it's mostly a shot in the dark ( no pun intended) as to your dosage strength and combinations of ED meds while injecting..Good luck!!
The bottom line is you have to kind of experiment with what works best for you...but I would lean to the conservative side.. Everybody is different and your responses to the mixing the Trimix with Tadalafil may be very different than mine. I would also discuss it with your URO guy. Having a close friend who is a retired Doc, he has told me physicians are trained to error on the side of caution...and no Doc is looking to be sued for giving off the road advice on these things. I often have said on this forum, in all the years I've been on Trimix and on this forum I've never had an erection lasting longer than 1 hour. IDK if guys on here exaggerate, or my penile arteries are so clogged that it's impossible for me to have such a long lasting erection...plus I do have some venous leakage..I wear a cock ring to help that too...Welcome to the wonderful world of Trimix where it's mostly a shot in the dark ( no pun intended) as to your dosage strength and combinations of ED meds while injecting..Good luck!!
70 year old legally separated retired health-care professional. ED began in my early 50's. Viagra worked great for about 5 years, then had cardiac by-pass surgery and eventually moved to injections about 10 years ago.
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Re: Trimix and Tadalafil Combination - good idea or bad idea?
My urologist prescribed the 5mg of Cialis and I take it daily whether or not I was going to use the Trimix didn’t concern him!
Diagnosed venous leak. Going with injections rather than implant for the time being.
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Re: Trimix and Tadalafil Combination - good idea or bad idea?
Thank you. When I start back on Tadalafil, I think I am going to start with 10 mg and see if that will be ok for my BPH. I felt like 20 mg might be to much, that is why I cut it in half and took half in the morning and half at night. I suppose at any point I had 10 mg or more in my system at at time.
Still figuring out my Trimix dose and formula, which has now become Quadmix. The Quadmix is the same as my Trimix formula, but ads Atropine and now is 30MG/1 MG/20MCG/.1MCG/ML.
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Re: Trimix and Tadalafil Combination - good idea or bad idea?
For those of you who are using Tadalafil and Trimix together. Did you stop taking Tadalafil and find your dosage for Trimix and then start back on Tadalafil with a reduced dose of Trimix? Or were you taking Tadalafil, did not stop taking Tadalafil and just started Trimix on a low dose?
Still figuring out my Trimix dose and formula, which has now become Quadmix. The Quadmix is the same as my Trimix formula, but ads Atropine and now is 30MG/1 MG/20MCG/.1MCG/ML.
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