I've read somewhere that PGE1 targets the venous outflow and other compounds like Papaverine target the arterial inflow, but then I see elsewhere that virtually every compound used in these mixes works by "relaxing blood vessels" which ends up working systemically, because your dick is just one part of the whole circulatory system. Eventually the drugs get everywhere your blood goes.
GERD is currently the only side I've noticed from injection and while it's milder than the effects from Sildenafil, it's still annoying.
Does anyone know if certain mixes are more benign than others in terms of affecting the esophagus?
Are All Mixes the Same Regarding GERD?
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edjohn
- Posts: 52
- Joined: Mon Aug 14, 2023 11:10 am
Are All Mixes the Same Regarding GERD?
Oct 7, 2025 - Coloplast Titan XL - Touch pump - 26cm - 0.5cm RTE with Jonathan Clavell. Still sorting out TRT; plan to try a "modified natty" approach without injections.
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bldoink
- Posts: 3696
- Joined: Mon Apr 03, 2017 12:58 am
- Location: Fl.
Re: Are All Mixes the Same Regarding GERD?
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Last edited by bldoink on Fri Aug 08, 2025 10:44 pm, edited 1 time in total.
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GoodWood
- Posts: 1344
- Joined: Sun Jun 16, 2019 1:07 pm
Re: Are All Mixes the Same Regarding GERD?
I’ve never heard of any of the injections causing GERD.
It’s such a small amount of medication the systemic (vs local) effects would be tiny. I use a large amount of a very concentrated mix and I’ve never noticed any systemic side effect. Local ones (ache) yes, but nothing systemic.
It’s such a small amount of medication the systemic (vs local) effects would be tiny. I use a large amount of a very concentrated mix and I’ve never noticed any systemic side effect. Local ones (ache) yes, but nothing systemic.
57yo, NYC. ED started at 40. Pills, then shots for 10 years. 24cm Coloplast Titan XL w/classic pump by Dr Eid 3/25/2025. Will meet for show & tell.
Implant journal: [url] viewtopic.php?f=6&t=26225[/url]
Implant journal: [url] viewtopic.php?f=6&t=26225[/url]
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jimmyd24
- Posts: 142
- Joined: Tue Dec 08, 2015 8:34 am
- Location: Florida
Re: Are All Mixes the Same Regarding GERD?
WOW.
I never thought about this. I do have GERD.
And although Viagra doesn't work for me anymore, I still have GERD, and have been on medication for it.
I never thought about this. I do have GERD.
And although Viagra doesn't work for me anymore, I still have GERD, and have been on medication for it.
Started with Viagra at age 40. Worked good for about 12 years.
Tried Trimix injections, worked great for about 8 years
Now Trimix no longer works.
I got implant on Oct 26th 2022.
Tried Trimix injections, worked great for about 8 years
Now Trimix no longer works.
I got implant on Oct 26th 2022.
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