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Hi

i have been prescribed trimix. i get erections without meds but unable to hold it for penetration. oral meds like viagra are giving me erections and things are working fine during foreplay but everything is failing during penetration. i get anxiety since i am not used to penetration sex. here is my little background viewtopic.php?f=14&t=25247


since i have my first session of trimix trial dose with a mens health clinic in canada so i have few questions:

1) since i am 39 fit and muscular, no cardiovascular or weight or hormone issues. decent testerone as well so what would be the starting dose of trimix likely for me? i got two different opinions. my urologist who is based in USA (I am from canada) said we will start with 10 units and set up a baseline. however the sexual men health clinic in canada where i am getting the trimix program from said they will start the dose from 2.5 units. i think 10 is two high for a person like me. what do you guys think?

2) how much does the formulation and proportion of the three meds in trimix matters? i know that the ingredients are: alprostadil, phentolamine, and papaverine. for a newbie what would be the ideal % of these ingredients?

the precription i got has 8.33 0.83 22.5. pharmacist told me 8.33 is the alprostadil. i forgot the other two.

is it possible that someone gets a lower dose of 5 and gets perfect erection but if they change the proportion of these ingredients and take a separate dose of 5 units then results will be different.

3) My urogolist said that many people make stupid mistakes with trimix and this is why they face risks of priapism or trimix not working for them. he gave me one example: he said people due to wrong injection technique sometimes end up missing inserting all the units in their penis and some of the units leaks out hence they feel that its not enough. this prompted them to double the dosage and next time when they do it correctly they end up increasing the dosage by inserting all the units and end up facing the risk of priapism. what is the correct injection technique and how often this happens.

please advise.

It sounds like your doctor is giving good advice. However the clinics recomendation to start at a lower dose first has merrit. Some guys are very sensative to the meds and you won't know if that's you until you try.

The makeup of your mix is very important. The strengths of the mixes vary considerably. You must experiment carefully to determine the correct mix and dose for you. You didn't mention what the strength of the components of your mix is.

Be sure and read as many of the older threads in the "Injection" sub-forum as you can stand. There's a lot of good info there with various techniques you can experiment. A couple of key points:

Never force the plunger down. If it doesn't depress easily you're at the wrong depth. Generally you aren't deep enough but you can also go too deep. You'll have to experiment. Every dick is different.

If you're capable of giving yourself a chubby before injecting you may find that will increase the size of the target, the corpus cavernosum, making hitting the target eeasier.

If you draw up a syringe ahead of time be sure to leave a little air at the top. That allows you to expell the air right before injecting which tends to fee up the plunger which can kind of take a set at the previous position. That set can interfere with feeling plunger resistance.

Always massage your penis while compressing the injection location for a couple of minutes both to prevent bleeding and to spread the injection meds.

Consider experimenting with novelty/sex shop cock rings. Some guys find their use helpful. See the "Cock Ring" thread in the "Members Only" sub-forum for some somewhat random suggestions.

I may add to this response later.

Good luck.

bldoink wrote:It sounds like your doctor is giving good advice. However the clinics recomendation to start at a lower dose first has merrit. Some guys are very sensative to the meds and you won't know if that's you until you try.

The makeup of your mix is very important. The strengths of the mixes vary considerably. You must experiment carefully to determine the correct mix and dose for you. You didn't mention what the strength of the components of your mix is.

Be sure and read as many of the older threads in the "Injection" sub-forum as you can stand. There's a lot of good info there with various techniques you can experiment. A couple of key points:

Never force the plunger down. If it doesn't depress easily you're at the wrong depth. Generally you aren't deep enough but you can also go too deep. You'll have to experiment. Every dick is different.

If you're capable of giving yourself a chubby before injecting you may find that will increase the size of the target, the corpus cavernosum, making hitting the target eeasier.

If you draw up a syringe ahead of time be sure to leave a little air at the top. That allows you to expell the air right before injecting which tends to fee up the plunger which can kind of take a set at the previous position. That set can interfere with feeling plunger resistance.

Always massage your penis while compressing the injection location for a couple of minutes both to prevent bleeding and to spread the injection meds.

Consider experimenting with novelty/sex shop cock rings. Some guys find their use helpful. See the "Cock Ring" thread in the "Members Only" sub-forum for some somewhat random suggestions.

I may add to this response later.

Good luck.

thanks so much for your reply.

this is the prescription i got.

8.33 0.83 22.5. pharmacist told me 8.33 is the alprostadil. i forgot the other two.

what do you think about this dose concentration?

roy123 wrote:
thanks so much for your reply.

this is the prescription i got.

8.33 0.83 22.5. pharmacist told me 8.33 is the alprostadil. i forgot the other two.

what do you think about this dose concentration?

It's a fairly weak starter mix.
I'll assume the ingredients are per ml which is most common. Also the amounts you list would suggest it's listed as per ml. Some will give the ingredients per vial size which can be 1ml, 2.5ml, 5ml or even 10ml. So in those cases you would have to divide by vial size to get the per ml value. But usually the label shows the ingredients as per ml regardless of the vial size. Mine comes in ten 1ml vials per order. I like it dispensed that way but I think that's probably the least common dispensing method.

Your mix should be 8.33 mcg Alprostadil (also known as Prostaglandin E-1 or PGE1) / 0.83 mg Phentolomine / 22.5 mg Papaverine. Most often the alprostadil is given in micrograms (mcg or ug) while the other ingredients are given in miligrams (mg). 1 Microgram (ug) = 0.001 Milligrams. The order the ingredients are listed in varies but most often it's Papaverine/Phentolomine/Alprostadil. However yours has the alprostadil listed first. The alprostadil is most frequently just listed as PGE. I would expect your label to say: 8.33mcg PGE / 0.83mg Phent. / 22.5mg Pap.

bldoink wrote:

roy123 wrote:
thanks so much for your reply.

this is the prescription i got.

8.33 0.83 22.5. pharmacist told me 8.33 is the alprostadil. i forgot the other two.

what do you think about this dose concentration?

It's a fairly weak starter mix.
I'll assume the ingredients are per ml which is most common. Also the amounts you list would suggest it's listed as per ml. Some will give the ingredients per vial size which can be 1ml, 2.5ml, 5ml or even 10ml. So in those cases you would have to divide by vial size to get the per ml value. But usually the label shows the ingredients as per ml regardless of the vial size. Mine comes in ten 1ml vials per order. I like it dispensed that way but I think that's probably the least common dispensing method.

Your mix should be 8.33 mcg Alprostadil (also known as Prostaglandin E-1 or PGE1) / 0.83 mg Phentolomine / 22.5 mg Papaverine. Most often the alprostadil is given in micrograms (mcg or ug) while the other ingredients are given in miligrams (mg). 1 Microgram (ug) = 0.001 Milligrams. The order the ingredients are listed in varies but most often it's Papaverine/Phentolomine/Alprostadil. However yours has the alprostadil listed first. The alprostadil is most frequently just listed as PGE. I would expect your label to say: 8.33mcg PGE / 0.83mg Phent. / 22.5mg Pap.

thanks for your input. i told my history to the urogolist and i suspect he prescribed me this based on the fact that i am having difficulty in getting and holding erections during penetration sex only. otherwise its ok for me. in foreplay i do have erections but as soon as penetration times comes i get tensed. i have limited penetration experience and have no experience in positions except spooning. during penetration i have constant worry about losing erections. cialis and viagra are only working for me during foreplay.

do you have any idea about estimates (concentration of each ingredient in trimix) given to a newbie which 39 or 40 and fit without any cardiovascular health or other health issues?

roy123 wrote:do you have any idea about estimates (concentration of each ingredient in trimix) given to a newbie which 39 or 40 and fit without any cardiovascular health or other health issues?

A weak mix is the way to start. You seem to be getting good medical advice. It's certainly worth starting with a low dose of a weak mix. You can always increase your dose or mix strength as needed under your doctors supervision.

bldoink wrote:

roy123 wrote:do you have any idea about estimates (concentration of each ingredient in trimix) given to a newbie which 39 or 40 and fit without any cardiovascular health or other health issues?

A weak mix is the way to start. You seem to be getting good medical advice. It's certainly worth starting with a low dose of a weak mix. You can always increase your dose or mix strength as needed under your doctors supervision.

thanks for your input. which of these components can turn a mix from weak to strong? is it alprostadil? so if i get a mix where alprostadil is higher then will that be considered as a stronger mix? am i right in assuming that 5 units of a mix where alprostadil is higher is considered as a stronger mix and long erection is likely in this case for a newbie as compared to another 5 units of a mix where alprostadil is fairly lower?

another question i really appreciate your help on. lets say i injected 5 units of my current mix and i get a 2 hour erection hard enough for penetration sex. but 2 days later i did the same and this time i did not get any erection at all. does that mean that i missed the insertion due to wrong technique the second time?

roy123 wrote:thanks for your input. which of these components can turn a mix from weak to strong? is it alprostadil? so if i get a mix where alprostadil is higher then will that be considered as a stronger mix? am i right in assuming that 5 units of a mix where alprostadil is higher is considered as a stronger mix and long erection is likely in this case for a newbie as compared to another 5 units of a mix where alprostadil is fairly lower?

another question i really appreciate your help on. lets say i injected 5 units of my current mix and i get a 2 hour erection hard enough for penetration sex. but 2 days later i did the same and this time i did not get any erection at all. does that mean that i missed the insertion due to wrong technique the second time?

The papaverine seems to generally max out at 30mg and I think the phentolomine generally maxes out at around 3mg. The alprostadil can go a lot higher, perhaps as high as 200mcg. You shouldn't even be worried about that stuff at this point. The alprostadiil is usually considered the heavy hitter of the 3 but also the ingredient most likely to cause ache or pain. Alprostadil is also commonly used as a stand alone mono-mix usually found in the form of proprietary prepackaged usits sold under the names of Caverject or Edex. Yes a more potent mix will certainly contain more alprostadil.

If a given mix works well one day and not the next then the most likely cause is a miss.

bldoink wrote:

roy123 wrote:thanks for your input. which of these components can turn a mix from weak to strong? is it alprostadil? so if i get a mix where alprostadil is higher then will that be considered as a stronger mix? am i right in assuming that 5 units of a mix where alprostadil is higher is considered as a stronger mix and long erection is likely in this case for a newbie as compared to another 5 units of a mix where alprostadil is fairly lower?

another question i really appreciate your help on. lets say i injected 5 units of my current mix and i get a 2 hour erection hard enough for penetration sex. but 2 days later i did the same and this time i did not get any erection at all. does that mean that i missed the insertion due to wrong technique the second time?

The papaverine seems to generally max out at 30mg and I think the phentolomine generally maxes out at around 3mg. The alprostadil can go a lot higher, perhaps as high as 200mcg. You shouldn't even be worried about that stuff at this point. The alprostadiil is usually considered the heavy hitter of the 3 but also the ingredient most likely to cause ache or pain. Alprostadil is also commonly used as a stand alone mono-mix usually found in the form of proprietary prepackaged usits sold under the names of Caverject or Edex. Yes a more potent mix will certainly contain more alprostadil.

If a given mix works well one day and not the next then the most likely cause is a miss.

thanks very much for your input. really appreciate it.

i read so many stories on reddit where just 5 units or 10 units ended up taking people to ER or priapism stage borderline. i guess 5 units of tremix could be different for me as compared to someone else since the % of ingredients within the tremix could be different. alprostadil could be higher for someone who is getting 4 hour erection with just 5 units. is my understanding correct?

Ideally your first injection would be in the doctors office under his/her supervison. Having too strong of a reaction requiring an ER visit can't be rulled out even with a small dose. There's just no way to know for sure, especially as your issue seems to be more psycogenic. Start low, it's better to waste an injection than to take too much for you. Also, it's often better to do at least a couple trials solo.