Injections, sensitivity reduction and no orgasm

Sticking a needle Where? Courage, guidance and help.
pumpless_mtfckr
Posts: 35
Joined: Fri Oct 18, 2024 8:17 pm
Location: USA

Injections, sensitivity reduction and no orgasm

Postby pumpless_mtfckr » Mon Nov 25, 2024 8:42 am

Why do some individuals experience decreased sensitivity and no penetration orgasm, even with rock-hard excellent erections from injections?

Masturbation with hand or sex toy is fine, but the problem is with human penetration :(

Can someone please enlighten me with the science behind this phenomenon?
Last edited by pumpless_mtfckr on Mon Nov 25, 2024 9:58 am, edited 3 times in total.

ape1100
Posts: 243
Joined: Wed Feb 23, 2022 12:35 pm

Re: Injections and reduced sensitivity

Postby ape1100 » Mon Nov 25, 2024 9:21 am

pumpless_mtfckr wrote:Why do some individuals experience decreased sensitivity with a rock-hard excellent erection from injections? Can someone please enlighten me with the science behind this phenomenon?


I dont think anyone wants to do this research or we would have some science on it. all i can say as that i am in the same boat. ever since i started trimix, i have not had a penetration orgasm since injection #4 and I’m almost 400 injections. trimix gives me great erections minus the desensitization that prevents me from orgasm. if i can have one, its with my hand or flashlight. all efforts to combat the effect have been primarily useless. it is a blessing and a curse. the wife gets worn out after so many orgasms but thinks shes not enough since she cant bring me to orgasm. :(
50+ yrs old. married 25+ years. hypothyroid, on TRT. 10+ years ED, viagra, cialis now 50% ineffective. now on trimix 2MG phentolamine/30MG papaverine/20MCG alprostadil

pumpless_mtfckr
Posts: 35
Joined: Fri Oct 18, 2024 8:17 pm
Location: USA

Re: Injections and reduced sensitivity

Postby pumpless_mtfckr » Mon Nov 25, 2024 10:04 am

ape1100 wrote:
pumpless_mtfckr wrote:Why do some individuals experience decreased sensitivity with a rock-hard excellent erection from injections? Can someone please enlighten me with the science behind this phenomenon?


I dont think anyone wants to do this research or we would have some science on it. all i can say as that i am in the same boat. ever since i started trimix, i have not had a penetration orgasm since injection #4 and I’m almost 400 injections. trimix gives me great erections minus the desensitization that prevents me from orgasm. if i can have one, its with my hand or flashlight. all efforts to combat the effect have been primarily useless. it is a blessing and a curse. the wife gets worn out after so many orgasms but thinks shes not enough since she cant bring me to orgasm. :(


Thank you kindly for responding. I wonder if it's because the nerves get compressed and get less blood flow?

CanGetItUpButNotOff
Posts: 240
Joined: Mon Sep 20, 2021 1:34 pm

Re: Injections, sensitivity reduction and no orgasm

Postby CanGetItUpButNotOff » Mon Nov 25, 2024 10:43 am

I'm only at three attempts at sex since starting TriMix, so my results are definitely not conclusory. First time, I came right on time. Second time, I want getting close so we paused but I stayed inside her and she finally came and that turned me on enough that I re-started and got there. Third time, it was a no-go for both of us. It's a complex puzzle but her arrousal and response at least plays some small role, but even that is counterproductive because pressure on her turns her off.

For reference, this was not atypical for my experience on Tadalafil+Sildenafil+Vyleesi (and combinations thereof) so it's premature to attribute orgasm difficulties to TriMix. It's not hard to find comments in this forum about decreasing sensitivity that go with increased TriMix doses, but as anecdotally valuable as they are, I've not yet seen any scientific validation. I had unsubstantiated hope that perhaps the perma-erection from TriMix would help me to keep going longer to get over the orgasm mountain top (But I think my own just plain physical stamina plus the wife's tendency to get sore make that unlikely).
Born 1954. Diabetes, hypertension and atherosclerosis. Sildenafil is iffy. Tri-Mix (30/3/20 Pap/Phen/PGE1) a godsend pending long-term efficacy. Daily Cialis. Tried LiESWT, Botox, PT-141, Eroxon, QST, DUS, Vertica, cabergoline, psychotherapy+hypnotherapy.

frwmw1
Posts: 451
Joined: Thu Oct 01, 2020 7:38 am

Re: Injections, sensitivity reduction and no orgasm

Postby frwmw1 » Fri Nov 29, 2024 8:26 am

I think you need to take the dose down a bit if orgasms are a problem.

I used to be able to orgasm often but its slowly went away.

It helps alot that my wife has intense orgasms now that I've gotten good at this.
45yo, venous leak. Pills increased tinnitus (very rare). Using bimix+atropine, 0.2 of:
Atropine Sulfate: 52MCG/ML, Phentolamine MES: 0.9MG/ML, Papaverine HCL: 26MG/ML

Ralph D
Posts: 4
Joined: Wed Nov 20, 2024 9:57 am

Re: Injections, sensitivity reduction and no orgasm

Postby Ralph D » Fri Nov 29, 2024 11:44 am

So I experienced no ability to orgasm inside my wife the first couple of times I used Trimix. Several nights ago I reduced the units and used a cock ring. Plus I stood over her while she was on all fours on the bed so I could get strong penetration and thrusting. In addition I cut down on the lube--just enough on her pussy to get inside her. Once I, which took some time, I had great friction and she remarked how great it felt too. All that to say I came in her big time! So, in essence I achieved both being rock hard and able to fill her up with my hot seed. She loved it.

scharff
Posts: 70
Joined: Wed Aug 23, 2023 8:50 am

Re: Injections, sensitivity reduction and no orgasm

Postby scharff » Fri Dec 06, 2024 10:18 am

I'm in the same boat. I CAN climax but it seems to take longer. Even masturbating. I have to say that it's fun to jerk off with my cock being stiff but it still takes time. That said, I've also found that I can climax faster / better when she gives me oral. So now, I inject and play with her often giving her oral to her climax and by then I'm erect and she goes to work. She gives great head...my cock is nice and hard....and she's a joy to watch while she makes her magic. I still have an erection after I release and we'll play some more even though I won't release again. That's how we've been doing it but before I injected, it was more of the traditional sex with her being penetrated vaginally or sometimes anally and predictable climaxes. It's all fun but it was frustrating for a while and she even began to think it was her.

John Dday
Posts: 38
Joined: Thu Sep 05, 2024 8:30 pm

Re: Injections, sensitivity reduction and no orgasm

Postby John Dday » Fri Dec 06, 2024 2:56 pm

Thanks for all your honest replies. I will be a Trimix user shortly, and there seems to be fine lines to its use. Thanks again.
1955. I have had ED for years. We were going for a Rigicon Infla10 in October 2024. Life got in the way (heart attack & stent), so we are now going for injections as a fill-in.

Martin6469
Posts: 668
Joined: Tue Feb 18, 2020 12:22 pm
Location: St. Louis, USA

Re: Injections, sensitivity reduction and no orgasm

Postby Martin6469 » Sun Dec 08, 2024 2:35 pm

pumpless: In my experience you don't want rock-hard. I have more glans sensitivity if the glans isn't bulging to its maximum. You might be on to something with your nerve compression idea.

And I think John's right: we DE guys must walk a fine line in using Trimix.
Age 79 in 2024. On testosterone replacement due to hypothalamus malfunction. (Attention depressed guys: low testosterone is a cause.) Healthy health nut but ED due to getting old. Like to keep enough cardiovascular ability to thrust for 30 min.

Musson
Posts: 420
Joined: Wed Nov 17, 2021 12:59 pm

Re: Injections, sensitivity reduction and no orgasm

Postby Musson » Sun Dec 08, 2024 2:43 pm

I’ve had a few times where timid kept me from reaching orgasm but ordinarily Trimix creates Tarzan screaming orgasms with me.
63yr old. PDwith 40% dor. Curve. Pre-PD 7”x6”.lost 2 in. due to PD. ED prior to PD. Switched from Sildalifil to Trimix Nov 2023 . Currently titrating Trimix for optimization.


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