MUSE® Reconstitution
Posted: Tue Feb 10, 2015 11:34 am
I recently purchased a 1,000µg MUSE® (alprostadil) urethral suppository from an online vendor. Instead of using it as directed I reconstituted the medicated pellet in 15ml of Bacteriostatic Sodium Chloride USP 0.9% for injection, resulting in the following concentration of alprostadil:
Alprostadil - ⅔µg/unit - 66⅔µg/ml
2.0µg ------- 3.0 units -- 0.03ml
4.0µg ------- 6.0 units -- 0.06ml
6.0µg ------- 9.0 units -- 0.09ml
8.0µg ------12.0 units -- 0.12ml
10.0µg ---- 15.0 units -- 0.15ml
12.0µg ---- 18.0 units -- 0.18ml
14.0µg ---- 21.0 units -- 0.21ml
16.0µg ---- 24.0 units -- 0.24ml
18.0µg ---- 27.0 units -- 0.27ml
20.0µg ---- 30.0 units -- 0.30ml
I then transferred the 15ml solution to three 5ml vials. I froze two vials and refrigerated the third. After 33 days the refrigerated solution has not lost its efficacy.
Has anyone else done something similar?
Alprostadil - ⅔µg/unit - 66⅔µg/ml
2.0µg ------- 3.0 units -- 0.03ml
4.0µg ------- 6.0 units -- 0.06ml
6.0µg ------- 9.0 units -- 0.09ml
8.0µg ------12.0 units -- 0.12ml
10.0µg ---- 15.0 units -- 0.15ml
12.0µg ---- 18.0 units -- 0.18ml
14.0µg ---- 21.0 units -- 0.21ml
16.0µg ---- 24.0 units -- 0.24ml
18.0µg ---- 27.0 units -- 0.27ml
20.0µg ---- 30.0 units -- 0.30ml
I then transferred the 15ml solution to three 5ml vials. I froze two vials and refrigerated the third. After 33 days the refrigerated solution has not lost its efficacy.
Has anyone else done something similar?