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As I understand it, the purpose of trimix is to allow using less Alprostadil, which causes pain, and to use a smaller volume of injection, but still get a good result. But it's not clear to me what the other two ingredients actually do, or why a doctor would change the relative concentration of the other two. Is there any information available online that would explain why adjustments to the relative strength of the three ingredients are made? Any algorithm for that?

Well for example, the Olympia pharmacy site says their standard trimix is 30/1/10, their Plus is 30/1/25, their Super is 30/3/100, and their Quadmix is 30/3/150/0.2. So papaverine never changes, and phentolamine "only" triples, even though Alprostadil increases 15 times. Would just like to understand why.

Thanks

Morgan

Trimix (30-2-20) my current prescription

Papaverine 30
Phentolamine 2 <duration>
Prostaglandin 20 <rigidness> other names Prostaglandin E1, PGE1 Prostaglandin E1 (PGE1)

Morgan,

I can tell you that the reason why Papaverine is stuck at 30mg/ml is that it is very difficult to get any more than that amount to stay dissolved in 1ml of water. Also in order to keep it in solution the PH of the solution has to be more acidic. I can tell you from experience that an acidic injection solution can turn your injected lazy limp penis into a bit of a burning torch in a few seconds (but luckily only lasts a few seconds -- but that is more seconds than anyone would want).

Also PGE-1 is an analog of the same PGE-1 that is released during the natural erection NOx cycle and it is less lasting than non-body occurring Papaverine and Phentolamine, So those two stick around longer and are not flushed or converted very quickly. The the body does know how to handle and dissipate away PGE-1 naturally.

That's all I got ...

J

As Jim says the PGE-1 dissipates pretty quickly, but the papaverine and phentolamine last longer. Both are also vasodilators as well as PDE-5 inhibitors (like Viagra) and papaverine tends to precipitate out of solution very rapidly unless the pH is just right. One pharmacy I dealt with told me to just put it in the microwave for a few seconds to heat it and that would solve the problem. What he forgot to mention is those few seconds would likely render the PGE-1 useless!! Moral of story -- if it precipitates, it mens the pharmacy doesn't know how to handle it properly!! Not all pharmacists graduated at the top of the class!

Big