Hey bidoink,
I love the Frio. I traveled with it for two weeks once and the juice was still strong when I got back. I highly recommend. I currently have the Mini Frio:
http://www.frioinsulincoolingcase.com/f ... allet.htmlIf I start buying juice from Coastal I will probably move up to the next larger size. I have not had problems with freezing-unfreezing. I have Trimix that is more than a year old. As I have moved up to stronger prescriptions several times I have kept the old stuff. Even after a nearly a year of being in the freezer some of it still works as it did when I first purchased it.
The out-of-date regulations in Florida are strict. Trimix is labeled as out of date after just 45 days. What people don't realize is that it will last much longer than that, especially if frozen.
I think Coastal is protecting itself by emphasizing the expiration dates along with the mini vials. But I am OK with that. Would rather have it in one 10ml vial though.
As for the Frio, I am not sure exactly what temperature setting it achieves. It was made to standards for keeping insulin at an acceptable standard. But that standard is fairly high when we think of it as being "cold." The standard is 59-77 degrees, from what I have read. That said, the Trio has never let me down.
For my travel by air, I sometimes just toss the vials into a 16oz thermos and cover them with ice. That passes through airport security just fine and I able to easily refill the ice on the plane (from the flight attendants) or in the airport. So the mini vials actually won't be a problem for me.