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Long-term ED increasing since 48 y/o, pills became less effective and with greater side-effects (V 100mg). One year (2017) of Caverject (74 jabs) about 30-35 ug that left quite a burning sensation for longer than I like and even interfered with ejaculation. Now on to Tri-Mix as Medicare doesn't cover Caverject.

Tri-Mix" 1st injection great, just a small red area ~1/8". Best result in a long time, believe me. And far less buring afterwards. On 2nd injection, he injection area L really swelled up and got red. Good result though. On the 3rd injection, hit the left with immediate red swelling so hit the right also. The whole bloody thing got fat red and swollen and no effective result. Saw Urologist who said give it a weeks rest and try again. I suspected an allergic reaction. Same 4th try with immediate red swelling like a bee sting , but hit the other side R instead with 20 ug of Caverject and the right side did not get impacted. But no "brass ring". 5th try back to Caverject (just prostaglandin) and no ill effect, good result (but hit a big subcutaneous vein, first time).

SO I have concluded that I POSSIBLY quickly developed an allergy to one of the other two Tri-Mix components. Talked with an ED Urologist specialist who suspected same and Rx'd a mono-mix of just a god dose of prostaglandin. No "allergic" reaction but it takes a .50 cc injection to get 30 ug of prostaglandin. Has anyone else heard of this or had it occur? I'm wondering about seeing an allergist to determine which of the other two I am allergic to - the Papavarine or Phentolmine so I can reduce the prostaglandin. Thanks ini advance.

I've never had that allergy reaction but then I'm on the mono-mix of straight prostaglandin (alprostadil) from a compounding pharmacy. It sounds like you need a stronger mono=mix. Mine is 80mcg per ml which is pretty strong. You might want to ask for 100mcg per ml.

As for the allergy issue I don't know. I guess you'd have to get some tiny scripts for those other two ingredients and have a trial. In the doctors office would probably be a good idea.

Former Tri-Mix was 30pap-1phent-20pge per ml. Got some mono-mix prostoglandin, 60 mcg/ml, and use 0.50-0.60 ml for 30-36mcg dose. My former Caverject dose was 30-40 mcg. Seemed suitable but a larger quantity to inject. Having a small quantity of papavarine and phentolmine delivered to do some alleregy testing so I can hopefully get to a bi-mix. We'll see.

I wanted to update this thread so as not to leave the wrong impression. I could write an epistle but will keep it short and sweet as I can. I do have a Word document write-up on the various testing/results and pics.

Conclusion: It appears I do not have a sensitivity/allergy to a component in TrI-Mix. I have concluded that if you do not get the shot fully into the cavernosa, the PGE causes trauma to non-venous tissue.

Discussion: After talking to my Uro and pharmacist about the bad reaction in February, we agreed on allergy/sensitivity testing via an allergist. Done as follows:

1. Scratch test using a very dilute sample of phentolomine, papavarine, PGE, the Tri-Mix, saline and histamine (two controls). No significant reaction with anything other than histamine.
2. Dilute solution injection of above into forearm. Slight reaction from papavarine and significant with histamine.
3. "Challenge testing" of papavarine and phentolomine at 1:100, then 1:10 and then 1:1 0.1 ml samples (since I had already had over 50 penile injections of 10-40 mcg of Caverject that was not a problem). No significant negative reaction from anything. But there was a mild/moderate theraputic reaction (mild boner) from the 1:1 phentolomine but NONE from the papavarine alone.

--> at this point the allergist suggested testing jointly and arm tissue test of the various mixes in a stronger dose.

4. Injection of 0.1ml of 30-1-10 Tri-Mix subcutaneously 1/8" into forearm. Within 1 hours a 3/4" red burning achy welt formed, it progressed a bit and subsided into a faint 1" dia purple bruise by day 2.
5. Injection of 0.05ml of 30mg/ml papavarine (1.5 mg) subcutaneously 1/8" into forearm. There was no significant reaction.
6. Injection of 0.033ml of 60mcg/ml PGE (2 mcg) subcutaneously 1/8" into forearm. QUickly rose to a 3/4" rd to purple welt that burned and really ached. Left a 1" blue bruise day 2 and took 4 days to mostly fade away. Significant reaction.

==> It appears that PGE injected into non-venous tissue causes hemmorhage and tissue damage.

(For completeness, phentolomine test, and papavarine + phentolomine tests pending.)

8. With trepidation, finally got around to full strength testing of the 30-1-20 Tri-Mix again into the penis. Test only at 0.1ml produced a good but sub-theraputic effect and no bad reaction.
9. Since then several uses of 0.3ml of the 30-1-20 Tri-Mix produced a good theraputic effect and no significant negative reaction. This is in addition to other mix ratio and strength tests of Tri-Mix components, PGE alone, and of my new 30-2-40 mix.

Reaction: So what does this mean? I believe in February when I started using the Tri-Mix (used Caverjct for over a year) I was trying to use up some old 5/16"x30ga B-12 syringes. My first two injections were successful. On #3/#4, I may NOT have gotten the needle in far enough or pulled it out a bit and put all or some of the mix in the skin layer above the cavernosa. Per the above arm skin testing, this would cause hemorrhaging within that non-venous tissue as it dispersed. The penis was fat, dark red, sore and swollen, but not stiff.

I have now used about 2.5ml of this same solution since then, using a fluffed penis and 1/2" x 30 ga needle with a normal and theraputic reaction.

Advice: DO NOT inject Tri-Mix or PGE into non venous tissue.

I wonder aloud here what would happen IF you penetrated the 2nd side of the cavernosa and got it into the area with the septum and nerve bundle. Could it cause nerve damage leading to anorgasmia. And, this may also explain the occasional small bruises left at the injection site with a small drop of fluid coming out the needle into the skin as it is inserted or withdrawn.

It seems the life of a guinea pig can be interesting.

Lots of pokes and lots of chemically-induced bruises. The bottom line is important:

- I have concluded that if you do not get the shot fully into the cavernosa, the PGE causes trauma to non-venous tissue.

==> It appears that PGE injected into non-venous tissue causes hemorrhage and tissue damage.

Advice: DO NOT inject Tri-Mix or PGE into non venous tissue.

And

I wonder aloud here what would happen IF you penetrated the 2nd side of the cavernosa and got it into the area with the septum and nerve bundle. Could it cause nerve damage leading to anorgasmia. And, this may also explain the occasional small bruises left at the injection site with a small drop of fluid coming out the needle into the skin as it is inserted or withdrawn.