Infection Risk grows with each surgery?

[astrius]

Dear team,

what is your take on the risk of infection getting higher with each surgery, be it due to revision or infection itself.

I have read something like ~50% infection risk after a certain (single-digit) number of surgeries.

The younger guys certainly will require several surgeries in their lifetime.

What is the evidence on this and would it discourage you from an implant?

[LastHope]

....What is the evidence on this...

This paper is usually referenced while discussing this topic.

International Journal of Impotence Research
30, 147–152 (2018)

Infection risk of undergoing multiple penile prostheses: an analysis of referred patient surgical histories.

https://www.nature.com/articles/s41443-018-0026-6

Abstract:
Inflatable penile prosthesis (IPP) is the gold standard for medically refractory erectile dysfunction. Infectious complications remain a significant concern in IPP revision surgery. We sought to evaluate the impact of number of IPP surgeries on subsequent infection rates. A retrospective analysis was performed on all new patients (self or outside provider referred) presenting for consideration of IPP revision or salvage surgery between 2013 and 2015. Histories were reviewed including number of prior IPPs, reason for evaluation, and rate, number, and timing of prior IPP infections. No patients were operated on by the primary investigator prior to data acquisition. We identified 44 patients with at least one prior IPP presenting for consultation regarding IPP revision/salvage. There were 88 IPPs placed by 28 different surgeons. In patients with two or more devices, 55% had at least two different surgeons. The most common reason for presentation was malfunction (52%). The risk of specific device infection was strongly correlated and increased based on number of prior IPPs: 1st (6.8%; 3/44), 2nd (18.2%; 4/22), 3rd (33.3%; 4/12), 4th (50%; 4/8), and 5th (100%; 2/2) (R2 = 0.90, p = 0.01). Similarly, overall rates of infection positively correlated with number of prior IPP-related surgeries performed (R2 = 0.97, p < 0.01). The median time to development of infection after most recent IPP surgery was 2 months (IQR 1–3.3 months). Infection rates of revision/salvage IPP surgery increase with each subsequent IPP placement or following IPP-related surgeries. The majority of patients referred for penile implant surgery can expect to have experienced at least one infection by their 4th device. These data represent a change in paradigm on revision prosthetic surgery.

[nuance]

wonder what Hakky and Clavell have to say about this paper...

[nuance]

Dear team,

what is your take on the risk of infection getting higher with each surgery, be it due to revision or infection itself.

I have read something like ~50% infection risk after a certain (single-digit) number of surgeries.

The younger guys certainly will require several surgeries in their lifetime.

What is the evidence on this and would it discourage you from an implant?

did you end up getting an implant?

[LastHope]

wonder what Hakky and Clavell have to say about this paper...

I wouldn't read the Mayo Clinic's percentages in this study like a gospel. It would be interesting to know each leading surgeon's clinical experience and how it correlates with this study.

From what I know, Dr. Perito atleast did not dismiss the increased risk. He also acknowledged this study in this video.

https://youtu.be/kOiaWfgiszw?si=LuS_LcKp622JKKiW

This section of the paper is noteworthy:

The cause for the increasing infection rates is unclear and may relate to reactivating bacteria present within a biofilm at the time of revision, reintroduction of bacteria, or reduced host defenses with additional scar tissue present with increasing numbers of surgeries