"The negative effects of smoking tobacco in the immediate postoperative setting have been well documented [10]. A meta-analysis of 140 cohort studies by Sørensen [11] revealed a adjusted odds ratio (OR) of 1.79 for postoperative SSI (surgical site infection) in smokers versus non-smokers. Likewise, an elevated OR of 3.60 (necrosis), 2.07 (wound dehiscence), and 2.27 (wound complications) was noted in smokers versus non-smokers. A reduction in SSI (OR=0.43) was identified if patients quit smoking at least 4 weeks preoperatively. As a meta-analysis with a large patient volume (n=479,150), this study represents level of evidence 1, for increased risk of SSI with perioperative smoking tobacco use. Cessation of smoking prior to surgery is ideal, however, patients should have quit at least 4 weeks prior to their operative case as increased lung secretions in the immediate post-cessation period create an increased risk of lung related infections [11]."
Source:
Hebert KJ, Kohler TS. Penile Prosthesis Infection: Myths and Realities. World J Mens Health. 2019 Sep;37(3):276-287.
https://doi.org/10.5534/wjmh.180123