Research on the Causes of Penile Fibrosis

[niarceel]

Bimix is comprised of Papaverine and Phentolamine: https://www.empowerpharmacy.com/drugs/bimix-injection.html

Trimix is comprised of Papaverine, Phentolamine, and Prostaglandin: https://www.empowerpharmacy.com/drugs/trimix-injection.html

Quadmix is comprised of Papaverine, Phentolamine, Prostaglandin and Atropine: https://www.empowerpharmacy.com/drugs/quadmix-injection.html

https://www.google.com/search?safe=active&client=firefox-b-1-d&sxsrf=ACYBGNSkpR7cfngfGz5Dmjswn9w3DUsaKA%3A1576121918707&ei=PrbxXdbRKonNtQa9ha7YBQ&q=does+papaverine+cause+fibrosis&oq=does+papaverine+cause+fibrosis&gs_l=psy-ab.3...486254.488254..488933...0.2..0.244.1117.0j7j1....3..0....1..gws-wiz.......0i71j33i160j33i299.gFrGWOR4oSw&ved=0ahUKEwjW6NjYl6_mAhWJZs0KHb2CC1sQ4dUDCAo&uact=5
"Penile fibrosis may result from a number of causes. ... Regular self-injection with intra-cavernosal stimulation therapy for erectile dysfunction, in particular papaverine, may cause focal areas of penile fibrosis to develop."

https://www.google.com/search?safe=active&client=firefox-b-1-d&sxsrf=ACYBGNSOw6JsKA5HxoqOvIjXtiljMLqA6Q%3A1576122408757&ei=KLjxXYbPLZCDtQaHqZTwBQ&q=does+phentolamine+cause+fibrosis&oq=does+phentolamine+cause+fibrosis&gs_l=psy-ab.3...88993.89933..91655...0.3..0.195.289.1j1....1..0....2j1..gws-wiz.......0i71j33i10.8VCciepheJk&ved=0ahUKEwiGg6_Cma_mAhWQQc0KHYcUBV4Q4dUDCAo&uact=5
"Phentolamine may cause acute and prolonged hypotension, tachycardia, ... including bilateral fibrosis of the corpora cavernosa, also have been reported."

https://www.google.com/search?safe=active&client=firefox-b-1-d&sxsrf=ACYBGNQ_6P_9v93VHjBbDW57c6trkZSYDw%3A1576122662859&ei=JrnxXcb_M8bItQbAiayIBg&q=does+prostaglandin+cause+penile+fibrosis&oq=does+prostaglandin+cause+penile+fibrosis&gs_l=psy-ab.3...24344.25635..26814...1.0..0.112.834.2j6....3..0....1..gws-wiz.......35i39.oPxmcvjaXqo&ved=0ahUKEwjGqsS7mq_mAhVGZM0KHcAEC2EQ4dUDCAo&uact=5
"It has been well documented as a side effect of papaverine, but there have been few reports associating penile fibrosis with prostaglandin E1 (PGE1, Alprostadil)."

https://www.ustoo.org/PDFs/Injection.pdf
"1. Papaverine is available at a low cost and is stable at room temperature but is less effective than the other medications and may have a higher tendency to cause scarring (fibrosis).
2. Papaverine plus phentolamine is more potent than papaverine alone but with the same potential side effects such as priapism and scar tissue formation.
3. Alprostadil rarely causes priapism but with its use pain is more common.(Alprostadil is also known as prostaglandin E-1 or PGE-1, in powdered form it may be called Caverject or Edex.)
4. Papaverine plus phentolamine plus Alprostadil (Trimix) is the most potent but requires refrigeration and has the same side effects as Papaverine and Alprostadil."

My research on the potential for accumulations of scar tissue from repeatedly injecting anything using a needle is that it causes the formation of collagen which can cause the formation of scar tissue. Bleeding and bruising further increases the risks of scar tissue forming.

Based upon what I've read so far, it appears that papaverine is the major source of substance induced scarring and fibrosis, while it is simultaneously the least effective ingredient in these chemical cocktails. My questions is, "Knowing this, why is it included at all?"

Question: How to reduce the papaverine we inject?

Answer: I've experimented with both Bimix and Trimix and I need less Trimix to produce the same quality of erection.

Less Trimix injected (than Bimix) means less papaverine injected.

As I continue to read, I may add to this post.

[niarceel]

I cannot take the pain from Trimix anymore. It's just too much.

I've switched back to Bimix (which works very well at 25-30 units) until I can get an implant.

[Biker60]

If you don’t have Peyronie’s you could try muse.