Research on Remedies for Fibrosis

[niarceel]

This post is a followup post to my original post: "Research on the Causes of Penile Firbrosis" - https://www.franktalk.org/phpBB3/viewtopic.php?f=5&t=13722

After a year of penile injections, I am fairly certain I have scarring in my penis. Because my sexual experiences with my wife have been so overwhelmingly wonderful, I am committed to the continuance of penile injections as my primary solution for overcoming ED.

Because penile scarring and fibrosis is all but guaranteed in response to these injections, I am researching ways to reduce/slow down the inevitable fibrosis that will result. If I can reduce the progressive damage that occurs from injections to a snail's pace, and if I can die before my penis does, I will have achieved my goal of continuing to have an incredible love life with my wife for the rest of my life.

I have not come to any conclusions yet, but my current line of research has promising implications for the reduction of existing scar tissue and control of/maintenance of on-going scar tissue production from injections.

As of this writing, I plan to experiment with some of the supplements referenced in the article links I have pasted into this post. If I achieve what I think is a notable level of success, I will do my best to follow up this initial post with what I perceive to be my results.

--------------------

Fibrin https://en.wikipedia.org/wiki/Fibrin - "...is a fibrous, non-globular protein involved in the clotting of blood. It is formed by the action of the protease thrombin on fibrinogen which causes it to polymerize. The polymerized fibrin together with platelets forms a hemostatic plug or clot over a wound site." Eventually, a clot/scab will be replaced by a scar.

Scar tissue is the body's natural response to an injury. Many body factors conglomerate around a wound/injury to protect the site from injury and allow the wound to heal.

Fribin is one of the major components of scar tissue. "Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process. ... In response to injury, this is called scarring."

For most injuries, the body overdoes the production of scar tissue. It creates more than is really needed to repair the wound. In healthy young people, the excess scar tissue is eventually removed. Older people do not have the same scar tissue removal process, at least not to the degree we did when we were young.

Most young peoples' bodies produce enzymes that, over time, dissolve the excess scar tissue. As we get older, our bodies' ability to produce these enzymes diminishes. This is the reason that we tend to have worse scars from injuries as we age. And they tend to stay worse longer for longer periods of time as we age, before eventually, possibly, being reduced in size and prominence.

Everyone scars differently. I have had a life long tendency to not generate a lot of scar tissue, especially when I was young, and when I have had a major surgery, the initial scarring has seemed to fade in prominence with time. I had my left shoulder reconstructed after experiencing a category 4 shoulder separation in a motorcycle accident. The surgery left a fairly nasty 6 inch scar. That was about 12 years ago. Today, I have to look to find the incision site; the scar has slowly "melted" away".

In contrast, my son generates keloid scars (https://www.google.com/search?client=firefox-b-1-d&q=keloid+scar) in response to wounds of any type. In response to both shoulder and knee surgeries, he has scars that look like good size ropes at the incision sites. Their prominence has not diminished much, if at all, with time.

Currently, there is considerable research on how to mimic in older people, young peoples' reductions of scar tissue. Current theory is that this can be accomplished by consumption of an appropriate amount and type of the correct enzymes.

After considerable reading, I'm not sure anyone knows the correct amount or type of enzymes that should be consumed. However, early research results are promising. I am going to cautiously begin experimentation with these type of enzymes to see what happens. Even if the enzymes accomplish nothing for me, they should do no harm. I've ingested some of them for years to aid digestion with nothing but positive results.

The use of them to remove and/or control excess scar tissue in the body requires a different approach. The pills/capsules that contain them must be enteric coated to ensure they pass through the stomach, unused, to be absorbed in the small intestine.

If you are interested, the documents on these websites are worth reading:
https://en.wikipedia.org/wiki/Fibrin
https://en.wikipedia.org/wiki/Fibrosis
https://en.wikipedia.org/wiki/Peyronie%27s_disease
https://en.wikipedia.org/wiki/Collagenase_clostridium_histolyticum - Enzyme used to treat fibrosis, Peyronie's disease, dismantles collagen; brand name is "Xiaflex."
http://spiritofmaat.com/maatshop/ANTIFIBROSIS.pdf
https://www.energeticnutrition.com/blog/2017/02/systemic-proteolytic-enzymes-scar-tissue/
https://worldnutrition.net/systemic-enzyme-therapy-intro/
https://www.energeticnutrition.com/blog/2009/09/feel-and-look-better-with-systemic-enzymes/
https://www.google.com/search?safe=active&client=firefox-b-1-d&tbm=isch&sxsrf=ACYBGNSu8ZiD7jyEcl0-4u2JbUgUX4tXPw%3A1576424250048&sa=1&ei=OlP2XerDApG2swX9upeQCQ&q=fibrosis+of+penile+tissue&oq=penile+fibrosis&gs_l=img.1.5.0l5j0i8i30j0i24l4.35360.36529..42858...1.0..0.137.919.0j8......0....1..gws-wiz-img.......0i67j0i7i30j0i8i7i30.4GAJeBw8yJo
https://www.yumpu.com/en/document/read/6468302/review-amelioration-of-penile-fibrosis-journal-of-andrology - See this section: "Proposed Amelioration and Reversal of Penile Fibrosis".
https://aestheticsjournal.com/feature/erectile-rejuvenation
https://speciality.medicaldialogues.in/drug-combination-effective-in-treatment-of-penile-fibrosis/
https://cyberleninka.org/article/n/386702/viewer
https://www.ncbi.nlm.nih.gov/books/NBK278925/ - VERY thorough and complete documentation.
https://www.theclarkfirmtexas.com/texas-propecia-lawyer-for-penile-fibrosis/ - "Propecia" drug treatment for male pattern baldness implicated in penile fibrosis
https://www.fasebj.org/doi/abs/10.1096/fj.09-144147?journalCode=fasebj - "Adenosine" treatment for supraventricular tachycardia implicated in penile fibrosis


If/as I find additional useful reading material, I will add it to this post.

[Whodat]

Thank you Nairceel.... Very intreresting

[niarceel]

I visited my Urologist yesterday and he confirmed that I have some fibrosis in my penis, although it's not severe. I do have a small nodule of scar tissue but no Pyronies Disease, at least not yet.

He seemed very unconcerned about it. I'm not sure how to interpret his response. Is it because my condition is not severe or because it's not his penis?

We discussed remedies for the fibrosis and the nodule of scar tissue:
1. A penile implant,
2. https://en.wikipedia.org/wiki/Collagenase_clostridium_histolyticum - Enzyme used to treat fibrosis, Peyronie's disease, dismantles collagen; brand name is "Xiaflex."

Xiaflex initially sounded like a good idea. But after reading brochures about it, my answer is "no".

Xiaflex has the possibility of numerous side effects, not the least of which is penile fracturing. I'm not willing to take that risk.

Without insurance to cover it, a full course of Xiaflex treatment costs $54,000.

At some point, if I live long enough,I will opt for a penile implant. In the meantime, I'm still going to use Trimix.

Going forward, I'm going to be extremely careful about how and where I inject.

[Robert66]

This post is a followup post to my original post: "Research on the Causes of Penile Firbrosis" - https://www.franktalk.org/phpBB3/viewtopic.php?f=5&t=13722

After a year of penile injections, I am fairly certain I have scarring in my penis. Because my sexual experiences with my wife have been so overwhelmingly wonderful, I am committed to the continuance of penile injections as my primary solution for overcoming ED.

Because penile scarring and fibrosis is all but guaranteed in response to these injections, I am researching ways to reduce/slow down the inevitable fibrosis that will result. If I can reduce the progressive damage that occurs from injections to a snail's pace, and if I can die before my penis does, I will have achieved my goal of continuing to have an incredible love life with my wife for the rest of my life.

I have not come to any conclusions yet, but my current line of research has promising implications for the reduction of existing scar tissue and control of/maintenance of on-going scar tissue production from injections.

As of this writing, I plan to experiment with some of the supplements referenced in the article links I have pasted into this post. If I achieve what I think is a notable level of success, I will do my best to follow up this initial post with what I perceive to be my results.

--------------------

Fibrin https://en.wikipedia.org/wiki/Fibrin - "...is a fibrous, non-globular protein involved in the clotting of blood. It is formed by the action of the protease thrombin on fibrinogen which causes it to polymerize. The polymerized fibrin together with platelets forms a hemostatic plug or clot over a wound site." Eventually, a clot/scab will be replaced by a scar.

Scar tissue is the body's natural response to an injury. Many body factors conglomerate around a wound/injury to protect the site from injury and allow the wound to heal.

Fribin is one of the major components of scar tissue. "Fibrosis is the formation of excess fibrous connective tissue in an organ or tissue in a reparative or reactive process. ... In response to injury, this is called scarring."

For most injuries, the body overdoes the production of scar tissue. It creates more than is really needed to repair the wound. In healthy young people, the excess scar tissue is eventually removed. Older people do not have the same scar tissue removal process, at least not to the degree we did when we were young.

Most young peoples' bodies produce enzymes that, over time, dissolve the excess scar tissue. As we get older, our bodies' ability to produce these enzymes diminishes. This is the reason that we tend to have worse scars from injuries as we age. And they tend to stay worse longer for longer periods of time as we age, before eventually, possibly, being reduced in size and prominence.

Everyone scars differently. I have had a life long tendency to not generate a lot of scar tissue, especially when I was young, and when I have had a major surgery, the initial scarring has seemed to fade in prominence with time. I had my left shoulder reconstructed after experiencing a category 4 shoulder separation in a motorcycle accident. The surgery left a fairly nasty 6 inch scar. That was about 12 years ago. Today, I have to look to find the incision site; the scar has slowly "melted" away".

In contrast, my son generates keloid scars (https://www.google.com/search?client=firefox-b-1-d&q=keloid+scar) in response to wounds of any type. In response to both shoulder and knee surgeries, he has scars that look like good size ropes at the incision sites. Their prominence has not diminished much, if at all, with time.

Currently, there is considerable research on how to mimic in older people, young peoples' reductions of scar tissue. Current theory is that this can be accomplished by consumption of an appropriate amount and type of the correct enzymes.

After considerable reading, I'm not sure anyone knows the correct amount or type of enzymes that should be consumed. However, early research results are promising. I am going to cautiously begin experimentation with these type of enzymes to see what happens. Even if the enzymes accomplish nothing for me, they should do no harm. I've ingested some of them for years to aid digestion with nothing but positive results.

The use of them to remove and/or control excess scar tissue in the body requires a different approach. The pills/capsules that contain them must be enteric coated to ensure they pass through the stomach, unused, to be absorbed in the small intestine.

If you are interested, the documents on these websites are worth reading:
https://en.wikipedia.org/wiki/Fibrin
https://en.wikipedia.org/wiki/Fibrosis
https://en.wikipedia.org/wiki/Peyronie%27s_disease
https://en.wikipedia.org/wiki/Collagenase_clostridium_histolyticum - Enzyme used to treat fibrosis, Peyronie's disease, dismantles collagen; brand name is "Xiaflex."
http://spiritofmaat.com/maatshop/ANTIFIBROSIS.pdf
https://www.energeticnutrition.com/blog/2017/02/systemic-proteolytic-enzymes-scar-tissue/
https://worldnutrition.net/systemic-enzyme-therapy-intro/
https://www.energeticnutrition.com/blog/2009/09/feel-and-look-better-with-systemic-enzymes/
https://www.google.com/search?safe=active&client=firefox-b-1-d&tbm=isch&sxsrf=ACYBGNSu8ZiD7jyEcl0-4u2JbUgUX4tXPw%3A1576424250048&sa=1&ei=OlP2XerDApG2swX9upeQCQ&q=fibrosis+of+penile+tissue&oq=penile+fibrosis&gs_l=img.1.5.0l5j0i8i30j0i24l4.35360.36529..42858...1.0..0.137.919.0j8......0....1..gws-wiz-img.......0i67j0i7i30j0i8i7i30.4GAJeBw8yJo
https://www.yumpu.com/en/document/read/6468302/review-amelioration-of-penile-fibrosis-journal-of-andrology - See this section: "Proposed Amelioration and Reversal of Penile Fibrosis".
https://aestheticsjournal.com/feature/erectile-rejuvenation
https://speciality.medicaldialogues.in/drug-combination-effective-in-treatment-of-penile-fibrosis/
https://cyberleninka.org/article/n/386702/viewer
https://www.ncbi.nlm.nih.gov/books/NBK278925/ - VERY thorough and complete documentation.
https://www.theclarkfirmtexas.com/texas-propecia-lawyer-for-penile-fibrosis/ - "Propecia" drug treatment for male pattern baldness implicated in penile fibrosis
https://www.fasebj.org/doi/abs/10.1096/fj.09-144147?journalCode=fasebj - "Adenosine" treatment for supraventricular tachycardia implicated in penile fibrosis


If/as I find additional useful reading material, I will add it to this post.

Dam you know your way around the internet i hope theyy can find a non injection method to use trimix and be as effective.. Injections are so old technology over 35 years other delivery methods are out there but do they acheive the same results this GNT. Med2005 is it the real deal or more smoke and mirrors i asked my pharmacy about a alprostadil cream she said they stopped making it her customers said it felt weird.There are lots of fakes out there claiming to cure ED but most are just looking for a fast buck.. but to stop scarring thru injections will require a different delivery method for trimix muse i have not tried but seems to have its own set of difficulty

[niarceel]

I have concluded that the risk from injections is too high. One out of every 8 men who inject get Peyronies Disease. Those odds are terrible.

My Urologist's PA told me that Peyronies Disease can appear suddenly, overnight, with no warning.

I'm giving up on injections and I'm going to have an implant.