What Causes Scarring? Injections or the Medication?

[kinggg]

Do injections themselves cause scarring not the chemicals in the med?

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[stephen54]

The act of injecting (regardless of the drug being injected) can result in small hematomas / bruising. But it ordinarily should not (assuming you apply firm pressure to the injection site for at least several minutes after injecting. I don't think most of us probably followed that instruction as closely as we should have. After all, someone else is naked nearby and we're pretty motivated to do many other things besides stand there applying pressure to our dicks).

Scarring - can certainly occur with repeated injections into the same site. Regardless of the drug in the syringe. Problem here is...most of us only have a pretty finite # of places we can inject. When you subtract any spot with blood vessels present, then subtract everywhere that is not between the typically recommended angles of injection (9-11 o'clock and 1-3 o'clock)...and if you inject reasonably frequently, ie multiple times per week...you just run out of real estate and now you're injecting repeatedly in roughly the same...or, the exact...tissues.

The prostaglandin (typically, alprostadil) is the source of the other troublesome stuff - ie, local tissue site pain, accumulative chronic fibrosis, and some other fun things are possible, too).

That being said...Trimix can be a ridiculously fun ride. Total superhero ridiculous sex possible and for a lot of years, potentially. I did it for 9 years and yes, it ultimately caused too much of this and too much of that and I went with implant last month...but injections were tremendous and for a long time.

[Happy Toy]

I used Trimix for 12+ yrs and had no ill effects from them other some bruising from time to time from not applying pressure at the injection site long enough. Like was said, you have other things on your mind . While they worked I really liked them, would stay hard for 2+ hrs., and nice and plump for another hour. They also added over an inch to my girth, 6.5+" , really liked that! But I ended up loosing that "added" girth with the implant , but I would not trade my hard dick for the fatter one that would not stay hard.
So apply the pressure and enjoy a hard dick it gives you for as long as you can and don't worry about what might happen.

[bldoink]

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The prostaglandin (typically, alprostadil) is the source of the other troublesome stuff - ie, local tissue site pain, accumulative chronic fibrosis, and some other fun things are possible, too).
................................

A very good post with the exception of the above quoted paragraph. It is my understanding that while, yes, Alprostadil is recognized as the tri-mix ingredient most likely to cause pain, it is also the ingredient thought to be the least likely to cause tissue damage and was thought to be pretty much risk free in that department. However, some more recent studies have cast doubt on the belief that alprostadil is totally benign as far as risk for damage. I believe it is still thought to be the ingredient with the least risk of tissue damage with Papaverine and Phentolamine riskier with the Phentolamine the riskiest.

[kinggg]

That being said...Trimix can be a ridiculously fun ride. it ultimately caused too much of this and too much of that and I went with implant last month.

Hey stephen,

Appreciate the reply. When you said the trimix "caused too much of this and too much of that" what exactly did it do to you?

And hows the implant treating you? Which do you prefer, the implant or injections? Any regrets?

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[kinggg]

But I ended up loosing that "added" girth with the implant , but I would not trade my hard dick for the fatter one that would not stay hard.

Hey happy toy,

Thanks for replying. How many inches did you lose with the implant?

What did you mean by not trading your hard dick for the fatter one that wouldnt stay hard?

Looking forward to your reply!

[stephen54]

.................................
The prostaglandin (typically, alprostadil) is the source of the other troublesome stuff - ie, local tissue site pain, accumulative chronic fibrosis, and some other fun things are possible, too).
................................

A very good post with the exception of the above quoted paragraph. It is my understanding that while, yes, Alprostadil is recognized as the tri-mix ingredient most likely to cause pain, it is also the ingredient thought to be the least likely to cause tissue damage and was thought to be pretty much risk free in that department. However, some more recent studies have cast doubt on the belief that alprostadil is totally benign as far as risk for damage. I believe it is still thought to be the ingredient with the least risk of tissue damage with Papaverine and Phentolamine riskier with the Phentolamine the riskiest.

Hi bldoink -

You could be entirely right. It's like anything else, there's what's reported in medical literature (often with such fractional percentages of occurance that all we can do is smirk and say, "yeah...right") and then there's the particular experiences and inclinations and of course biases which develop over time on the part of an infinite # of physicians and surgeons. Mine seemed to have a strong belief that alprostadil was in fact the devil you want to get to know - it arguably gave the most bang for most guys of the 3 ingredients in the mix, but it also brought with it the most side effects.

He made the point to me at our first substantial discussion of injections (supported by single agent alprostadil FDA labeling and post-market surveillance of single agents such as Caverject, for instance) that fibrosis, pain, numbness, irritation, pruritis, erythema...those all come with the territory with alprostadil alone. Pfizer would have you believe that the fibrosis rate for single agent alprostadil is only (their self-reported) 3%. However, this drug was approved by FDA 25+ years ago. The post-marketing surveillance requirements are comically low for a drug this old which, on balance, is being used by an extremely small fraction of the population. It's just not vividly on FDA (or most anyone else's) radar at this point to commit time and resources to continue to rigorously study and collect new data.

So that 3% fibrosis rate which ends up in the drug's approved FDA labeling...when and how did Pfizer gather that data? With guys who were on alprostadil for how long? Six months? 1 or 2 years? I don't know the answer to any of that but my assumption is that the data collection didn't include guys on alprostadil for 5 years or for 9-10 like I was. And so, how many guys are developing sub-clinical fibrosis, slowly, over long periods of time, which can't be, or isn't readily recognizable to themselves nor to their physician during standard office exams? And therefore leaving the published common perception and talking point that a fibrosis rate is so low. Low based on what criteria and population measurement?

I don't know the answer and I don't have a dog in this fight. It's a good discussion. I only had my personal experience. We absolutely loved Trimix while it lasted and even the pain and challenges which accompanied Trimix were entirely outweighed by the prolonged and crazy shit it allowed us to experience and for a lot of years (including 2+ years where my fibrosis was confirmed by my doc and well known to me, but I just kept looking for other injection sites and putting off implant as long as I could). I understand this was only my personal experience. I'm sure there are guys whose development of fibrosis is quicker than mine was, and more troublesome for them than mine was.

Maybe some (or, a lot) of this is just clearer expectation-setting by the physician on the front end, you know? My doc told me in 2011 when I started injecting here are the risks, a, b, c, d. I did my diligence educating myself as best I could, but likewise my doc was extremely thorough educating me back, and ultimately I did the risk vs rewards math on injections for myself and ultimately had a great overall experience. But I went into injecting with my eyes wide open about the risks and downsides. None of the difficult things (physical and mental both) which accompanied injecting came as much of any kind of a surprise to me. I rationally understood that I was very unnaturally stabbing my dick 175-200 times per year with chemicals which didn't belong there and that ultimately this would not be without consequence..

[stephen54]

That being said...Trimix can be a ridiculously fun ride. it ultimately caused too much of this and too much of that and I went with implant last month.

Hey stephen,

Appreciate the reply. When you said the trimix "caused too much of this and too much of that" what exactly did it do to you?

And hows the implant treating you? Which do you prefer, the implant or injections? Any regrets?

.

Hi kinggg,

Trimix for me didn't really cause appreciable pain until I was maybe 4-5 years in, and that was only when my initial mix #5 started fading and I began using higher concentration mixes. But then, for sure, pain was my biggest enemy. Pain upon injecting, pain immediately afterward, and a dull hammer of a throbbing pain which could easily linger a day or two, even up to the next injection. But it wasn't debilitating pain, it was just...there. The trade off for me/for us was always easy - total mind-boggling Olympic sex and for a lot of years.

I also over time experienced some itching (minor) and bruising later on (more problematic). My last 2 years or so, it was known that I had some fibrosis developing in my most comfortable (frequent) injection area. But we pressed on. Tried to delay implant as long as possible. Triggering decision in my mind was a combination of pain escalation and diminishing effective hardons even at extremely high concentrations and volume of injection. I would have continued injecting if it was only the pain - great sex always numbed the pain for me, so to speak. But the waning efficacy was the deal breaker.

I was only implanted on 11/18/2019 - no official test drive with implant yet.

But to answer your question as to regrets...no, absolutely none with injections and none with implant, even though implant has not been...um...fully evaluated as yet. No regrets anywhere here. Did what I (we) had to do at the time. Pills, no regrets, injections no regrets, implant no regrets. We just aggressively pursued whatever the next step in technology afforded us and we rode that as long as it delivered the kind of effectiveness we wanted. When it no longer did, we simply moved on and embraced the next thing. So my way of thinking always was, each of these approaches has its place and its upside and downsides, and I just sort of accepted all that. But I guess my disclaimer here, and I entirely acknowledge this about us, is that we are very highly sexual together and so the demands and expectations we put on any one of those ED technologies might be more than some other people put on those technologies. We expected and wanted...a lot. So we really pushed things along the continuum of what was available and whatever the downsides were maybe bothered us less than it might bother others, I'm not sure!

[stephen54]

I used Trimix for 12+ yrs and had no ill effects from them other some bruising from time to time from not applying pressure at the injection site long enough. Like was said, you have other things on your mind . While they worked I really liked them, would stay hard for 2+ hrs., and nice and plump for another hour. They also added over an inch to my girth, 6.5+" , really liked that! But I ended up loosing that "added" girth with the implant , but I would not trade my hard dick for the fatter one that would not stay hard.
So apply the pressure and enjoy a hard dick it gives you for as long as you can and don't worry about what might happen.

Well said, man, exactly!

[kinggg]

I was only implanted on 11/18/2019 - no official test drive with implant yet.

Hi stephen54,

Wow! So you just recently implanted! No word yet as to efficacy as you said. Definitely too early to tell. Hope recovery is smooth for you. I'll keep tabs on your progress. Am thinking of getting an implant. But I still get partial morning wood on occasion when my penis feels like getting it which is weird as hell like its got a mind of its own to decide when and when not to get a hardon regardless of when I want one.

Looking forward to your test drive once youre cleared for it stephen! Thanks.

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