Why Do Pills Stop Working? Any Way to Get Them to Work Again?

[niarceel]

Aging causes deterioration of the interior of the penis. Lack of oxygen is the root cause of the problem which worsens with age (it causes penile scarring and nerve death). This one thing causes ED in virtually every older man. If you can arrest this process of deterioration, you can go a long way toward saving your love life.

Nightly, small doses of Viagra/Cialis can help maintain penile health and possibly the return of nocturnal erections, which are essential for penile health. These 2 drugs cause arterial dilation which improves blood flow and oxygenation of the penis. After I started taking a small, nightly dose of either drug, I began to have occasional nocturnal erections again, which I had not experienced in 5-10 years.

[Simbarn]

What happens is that the brain stops making the synapse that you are aroused and/or diminished penile sensitivity.

I do not think we can be so specific or certain that one speculative causation is the reason that PDE5 inhibitors seem to lose effectiveness over time. There is in my opinion more convincing evidence supporting other etiologies of ED which would help explain this phenomena. However, the ageing brain could have a part to play in the pathophysiology of ED in some circumstances.

[Simbarn]

What happens is that the brain stops making the synapse that you are aroused and/or diminished penile sensitivity.

I do not think we can be so specific or certain that one speculative causation is the reason that PDE5 inhibitors seem to lose effectiveness over time. There is in my opinion more convincing evidence supporting other etiologies of ED which would help explain this phenomena. However, the ageing brain could have a part to play in the pathophysiology of ED in some circumstances.

[Robert66]

The penis is essentially a balloon. It must be inflated and not deflate for a man to have a good, sustained erection when sexually aroused.

There are 2 factors at work that allow this to happen:
1. Vasodilation - dilation of the small arteries going into the penis which engorges it with blood, and
2. Vasoconstriction - constriction of the small veins going out of the penis to restrict blood from leaving the penis.

Assuming you have a healthy, strong cardiovascular system with plenty of blood flowing, the usual cause of ED drugs no longer working is venous leakage. It could be any number of things, including something psychological, but from what the original poster said, I don't think so. Still, don't take my word for it. See a urologist.

I used Viagra and Cialis for almost 10 years before their desirable effects began to fade. I have a great cardiovascular system (I was a runner for decades), normal blood pressure, no arterial plaque or deposits, in overall good health, so, I asked my doctor, "What could be the problem?"

His answer: "Venous leakage". He explained to me that our veins have tiny check valves in them to prevent the back flow of blood in our bodies during the heart's diastolic (resting) phase of a heartbeat. As we age, these tiny valves fray around the edges and start to leak, causing some back flow.

That back flow out of the penis is enough to interfere with/ruin an erection.

If what I've written applies to you, your urologist will most likely recommend penile injections. I recommend that you start with Bimix. Then, as you need to, go to Trimix. It contains prostaglandin, a powerful group of chemicals that are responsible for both blood vessel dilation and constriction. In most men, Trimix causes pain as well as good erections.

I find the pain intolerable so I experimented with blending just a little Trimix with a larger dose of Bimix in about a 1/10 ratio. This has worked very well for me. I have the hardness of Trimix with only some discomfort, not pain.

https://www.franktalk.org/phpBB3/viewtopic.php?f=5&t=14553&p=128338#p128338 - My Bimix/Trimix experiments.

But the injections have a price: The risk of the formation of fibrotic scar tissue which can lead to Peyronies Disease in 1 out of 7-8 men who inject. Because of this, I am planning to have a IPP (Internal Penile Prosthesis) this year.

Great reply but i read scar tissue is a 3% thing for injectors and dafloa helps repair some of those viens well it did for me

[Robert66]

SORRY DAFLON

[kinggg]

The observations that have been made with regard to the loss of smooth muscle in the penile tissues and arteries would also help explain why the effectiveness of PDE5 inhibitors wane over time. PDE5 inhibitors work directly at helping the smooth muscle to relax. If the quantity and quality of smooth muscle is slowly decreasing it stands to reason that the effect of the inhibitors will also lessen. This does not take into account fibrosis and the deposition of collagen that also occurs with this loss of smooth muscle, which hinders penile elasticity and compliance. It also does not take into account the increase in sympathetic activity in the penile tissues as we age also. Both of which possibly contribute to venous leakage simply by not allowing the penis to expand enough to enable venous occlusion.

Hi slim,

Is there anything we can do to reverse the damage of aging on the CC so that pills can start working again as before?

.

[kinggg]

What happens is that the brain stops making the synapse that you are aroused and/or diminished penile sensitivity.
"

How can this synapse be re-awakened to reclaim lost libido and erections?

.

[kinggg]

I do not think we can be so specific or certain that one speculative causation is the reason that PDE5 inhibitors seem to lose effectiveness over time. There is in my opinion more convincing evidence supporting other etiologies of ED which would help explain this phenomena. However, the ageing brain could have a part to play in the pathophysiology of ED in some circumstances.

So what can we do to repair the CC from the ravages of aging to order for the penis to function well enough to the point that it can respond effectively to pills as they had before?

.

[niarceel]

Robert66,

You sent your response to my last post in a private message. I hope you don't mind but the information about what Daflon did for you is so important that I'm going to post our conversation on this thread.

-----------------

Robert66:
I started injections 2 years ago first script gave me a hard on but i sat sat down it faded. Next dr visit they gave an ultra sound leakage. Ready to give up on a plane ride in cheap seats my left leg swollen like balloon. Doc said your viens are not good put me on DAFLON. Two a day leg got better and back to almost normal same time my injections got better lasted longer and longer now almost 2 hours so why? If Daflon cured my tiny veins in leg is it possible it helped my venous leak? The med cost me 30 dollars for 30 days worth after 3 months i cut dose into half

Me: I don't think you and I have the same problem. I've never had my legs swell badly from sitting or anything else.

I Googled "Daflon":
"Daflon is composed of two ingredients: diosmin and hesperdin (flavonoids). It is used to treat venous insufficiency, or lack of blood flow, to the lower limbs with symptoms such as heavy legs, pain, and nocturnal cramps. It can also be used to treat chronic hemorrhoids."

From all the data I've studied, I think you had a venous leak problem associated with a pretty good size vein(s) in your leg(s). As a wonderful side effect, the administration of Daflon also fixed most of your ED problem(s).

Congratulations on having that work! That was a wonderfully simple solution. Most men's ED problems are more complex.

My problem is the really tiny veins near/at the base of my penis.

Before I was put on injections, I was asked to take a cardio stress test on a treadmill. I maxed it out, went for 1 minute longer than necessary (11 minutes total), and the last minute I asked the techs to increase the angle of the treadmill and increase its speed to see what I could do. I jacked my max heart rate up to 168 beats per minute, 8 bpm higher than a man 70 years old is supposed to be able to do, and I held it there for a whole minute. The techs said they'd only seen one other person do that (she was a long distance runner).

Here's why I was asked to take the cardio stress test:
The Cardiologist who ordered the cardio stress test told me that ED problems are often the first indication of a heart problem. He told me that the veins and arteries in the heart and the base of the penis are the smallest in the human body.

[I wonder why God did this to our penises? Maybe to keep us from becoming "dirty" old men? ]

My performance during the stress test proved I have no cardio/heart risks, and that I almost certainly have no vein or artery blockage in/at the base of my penis. So, the only thing left is venous leakage and both the Cardiologist and my Urologist told me its the little veins at the base of my penis that are my problem.

I asked my Urologist, who specializes in treating ED, if there was any way to fix the venous leakage? He said, "No, not currently, and the research to do so is not promising much in the way of successful treatments."

I guess all those years of me beating-off took a toll. (I'm kidding) I was told that my condition is just normal wear and tear from living.

Really, our bodies are "designed" to last about 40 years. That's enough time to reproduce and raise our young. As far as Life is concerned, that's a good reproductive strategy to continue the propagation of our species. Every year over 40 is a gift. Enjoy every one of them.

I thank God for modern medicine. If it wasn't for the technology and skills of modern medicine, I would have died 3 times, and if I hadn't died, I would have been a bedridden invalid twice. Modern medicine has given me my life back, and significantly improved the quality of my life, more than a few times. Now, again, it is helping me maintain the quality of my life (good sex with my wife).

It sounds like the administration of Daflon helped to give you back the quality of your life.

[niarceel]

kinggg,

This is a long post. I think it will be worth your time and effort to read all of it.

To paraphrase something Simbarn said in one of his posts:
"If you study enough information on ED, you eventually start to connect the dots about what the problem(s) is(are)."

First, don't assume you have a single problem. You may not; I didn't. I had a complicated set of problems. (My wife and I have been very successful in treating the symptoms I had. I am not certain we have treated and resolved all of the fundamental problems. But, the symptoms of my ED are gone and we again have a fantastic love life.)

Second, the human male erection process is complex involving many sub-processes that must all work correctly for you to have a normal sexual experience (desire, erection, tumescence, orgasm, ejaculation). It is possible to have success with some of those sub-processes but not all of them. For instance, it is possible to have an orgasm without ejaculation, and vice-versa. Anything less than the full and complete response is not the desired response. One or more failures in this complex process and its chain of events can inhibit/prohibit a good sexual experience.

Now, with you knowing all of that, I'll do my best to give you information and the benefit of my own experiences in solving what were for me, very confusing, multifaceted, ED problems. (It took my wife and I about a year to figure them out and resolve my problems.) Today, my love life is back and is again, wonderful.

You and I both do not know what your problem(s) is(are) so I'm going to give you more information than you probably need to resolve your problem(s). It's a condensation of a considerable amount of time and effort my wife and I expended to get my ED problems resolved and it will save you the time of having to perform the same research. But I want to caution you, this information is not a substitute for a good consultation with a good Urologist who specialize in treating ED. Eventually, you will need to have that consultation. But knowing the things I'm about to "tell" you will make your visit with the Urologist much more productive.

Here are a list of my ED symptoms that occurred suddenly, without warning, in January, 2018.
The confluence of them was the perfect storm:
> Complete failures of Viagra and Cialis to produce erections.
> Partial failures of Viagra and Cialis to produce erections. (An unusable erection or one that could not be maintained long enough)
> Penile numbness
> Loss of penile sensitivity
> Delayed Ejaculations, Small Ejaculations, or No Ejaculations
> Anorgasmia (failure to orgasm) - Good erection, hard, and for long enough to orgasm, followed by an inability to orgasm even though all the intense feelings preceding orgasm existed in my groin and penis, including a very intense mental state of lust and sexual desire. This was the worst problem of all. It injured me psychologically in ways that are difficult to explain and that I do not understand to this day. After failures to have an orgasm and ejaculation, during very intense sexual sessions with my wife, I would slide into intense grief, a state of mourning, and terrible depressions, usually for several days. My mind caved in on me. Feelings of desolation and hopelessness filled me. Life seemed brutally grim; there was nothing left to live for. I felt estranged from my wife who I dearly love. I was not myself.

Today, having resolved all of these symptoms, I will list the problems that were resolved and how they were resolved:
(Know that I was only able to resolve most of these problems because of the research my wife and I did.)
1. My wife and I stopped "edging" for quite a while, long enough for both of our brains to reset to more normal, quicker, sexual responses. To reset my brain's sexual responses, I started trying to orgasm immediately upon entering my wife. This finally created a breakthrough in my sexual response conditioning. returning me a normal sexual response (shorter elapsed time, from entry to orgasm). ("Edging" is the intentional delay of orgasm with the goal of maintaining intense sexual desire for long periods of time. We were (and still are) experts at this, and often had intercourse for hours, out of our minds with lust.)
2. I had changed from one medication to another in late December. It was part of the problem as the new medication significantly decreased penile sensitivity. I finally went back to the drug I been taking previously. This really helped.
3. I stopped doing furious, intense masturbation to finally reach the point of orgasm and ejaculation. This level of intense masturbation was desensitizing my penis.
4. I began to use light tension, constriction rings under and behind my testicles/scrotum to help maintain and enhance my erections.
5. Penile numbness was caused by 3 things: 1) Furious masturbation to reach orgasm, 2) "edging", 3) having constriction rings on too tight and/or for too long.
6. Penile loss of sensitivity: This was the hardest problem to solve. It was caused by 3 things: 1) A painkiller drug that reduced both pain and pleasure sensations (I went back to the original drug I had been taking, before January, 2018), 2) "Edging" too frequently when we made love, and 3) Deteriorating physical conditions inside by penis caused by age and oxygen deprivation (This was very hard to figure out, and only by research.) My penis had been slowly dying from oxygen deprivation, probably for years as I aged. I have rehabilitated my penis through nightly, small doses of Cialis, and use of a VED (Vacuum Erection Device). Both of these solutions have brought "new life" to my penis. It's larger, thicker, darker (full of oxygenated blood) both flaccid and erect, and, as far as I can tell, I have restored the penile sensitivity of my youth. Now, a gentle breeze gets the attention of my penis.
7. Erection failures: The problem was diagnosed as venous leakage for which there is currently no acknowledged cure in the medical profession (However, doctors don't know everything. Be sure to read the post by Robert66, it's URL is below.). That's why Viagra and Cialis had mostly stopped working for me. I finally went to a brilliant Urologist who specializes in the treatment of ED, Dr. James Hotaling at the University of Utah Hospital and Medical Research Facility in Salt Lake City, UT. This is a teaching and research hospital/facility that is on the cutting edge of medical research. After a cardio stress test, Dr. Hotaling prescribed Trimix injections which were incredibly effective, so much so that I have had to go to the ER twice to be treated for priamism. Long story, short version: I now use a blend of Bimix and Trimix, in a 1/10 ratio that I "blend" myself (documented in one of my posts) that give me "glass cutter" erections without the intense pain caused by the ingredient, prostaglandin, in Trimix. My first injections began in very late December, 2018, and my love life exploded into ecstasy in 2019, beyond anything my wife and I have ever dreamed of experiencing. We make love for hours and can never get enough of each other. The breakthrough for us was me being able to have erections lasting for hours, something I think many women would appreciate. I know my wife does.
8. Anorgasmia: There was one last problem to solve, my inability to reliably and/or fully orgasm. This problem was in my head, literally. Dr. Hotaling's P.A, S. Tolstrup, prescribed Cabergoline (I have posted about my experiences with this drug.), a drug that has an interesting side effect in many men, especially me. It can cause hyper-sexuality and this has been my experience of it. By the second time I took it, I experienced 2 successive orgasms in 20 minutes with my wife. My orgasms are now body wracking, so intense that I can't compare them to any others except for the "Oh, God" climaxes I've had. If they kill me someday, they will have been worth it. My ejaculations are complete; I don't think there is a drop of semen left in my body. And I am horny all the time. I don't need to orgasm to want sex with my wife. It's all good. As of today, I have had 7 mind-altering orgasms in a row, over a 3 week period, and not one that wasn't of this quality.

So, questions: What has brought me to this point, a point where everything seems to be fixed, or at least my ED symptoms are at bay? Was it one thing, several things, or all of them? Is the drug, Caberline, responsible for the quality of my orgasms, or would they have become like this anyway, having attended to all the other problems? I don't know. It's like trying to solve an algebraic equation with too many variables; it can't be solved. I really don't know.

Without knowing your exact problem(s), I'm now going to "shotgun" it(them) with everything I know. I encourage to pick and choose what works for you.

Below are URLs to posts I've made on this forum about a variety of ED problems that I've either researched and/or experienced first hand:
I sincerely hope one or more of them will lead you in the right direction to diagnose and fix your problem(s).

https://www.franktalk.org/phpBB3/viewtopic.php?f=3&t=13861&p=128517#p128517 - This is where I am now in overcoming my ED problems with great success.
https://www.franktalk.org/phpBB3/viewtopic.php?f=5&t=14515&p=128269#p128647 - posted by Robert66, maybe a treatment for venous leakage?
https://www.franktalk.org/phpBB3/viewtopic.php?f=3&t=13792&p=121448#p121448
https://www.franktalk.org/phpBB3/viewtopic.php?f=3&t=13861&p=121452#p121452
https://www.franktalk.org/phpBB3/viewtopic.php?f=3&t=13849&p=121819#p121819
https://www.franktalk.org/phpBB3/viewtopic.php?f=22&t=12368&p=121825#p121825
https://www.franktalk.org/phpBB3/viewtopic.php?f=22&t=13522&p=124384#p124384
https://www.franktalk.org/phpBB3/viewtopic.php?f=22&t=11080&p=123906#p123906
https://www.franktalk.org/phpBB3/viewtopic.php?f=22&t=13943
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4816679/
https://www.franktalk.org/phpBB3/viewtopic.php?f=4&t=13685&p=128506#p128506
https://www.franktalk.org/phpBB3/viewtopic.php?f=4&t=14380
https://www.franktalk.org/phpBB3/viewtopic.php?f=4&t=14380&p=126457#p126457
https://www.franktalk.org/phpBB3/viewtopic.php?f=6&t=13822&p=121070
https://www.franktalk.org/phpBB3/viewtopic.php?f=4&t=13288&p=126474#p126474
https://www.franktalk.org/phpBB3/viewtopic.php?f=6&t=14385&p=126522#p126480
https://www.franktalk.org/phpBB3/viewtopic.php?f=5&t=14553&p=128338#p128265
https://www.franktalk.org/phpBB3/viewtopic.php?f=4&t=14380
https://www.franktalk.org/phpBB3/viewtopic.php?f=3&t=12364&p=128871#p128871
https://www.franktalk.org/phpBB3/viewtopic.php?f=3&t=14551&p=128910#p128878

I wish you the best possible outcome and success. If you're inclined, please send me a message via the Forum to tell me of your progress and success.

Sincerely, Niarceel