Postby Lorentzianmanifold » Wed Sep 23, 2020 12:42 am
I think the best approach is using the following known erectile mechanisms in a stack formula which I am currently testing out and so far I have had success combing a melanocortin agonist with PDE5i drugs. However there are actually many more avenues that can be approached and due to side effects of PT 141 I decided to explore every possible avenue of erectile response.
First is obviously the pde5 inhibitors which obviously act through increasing nitric oxide levels in the endothelial tissue. I would recommend trying every single one before giving up on them because I had success with sildenafil but not tadalafil. I will soon try vardenafil which I'm hoping has an even greater effect?
Next is the melanocortin receptor agonists like PT14 which if did not have such serious side effects for me would be my cure!!!
Next is the dopamine receptor agonists like apomorphine would show great promise in a lot of studies for people that were non-responders to the pde5 inhibitors. Also in this class is cabergoline which also reduces prolactin levels which may be a contributing factor to your ED!
Next of course would be the alpha two blockers such as phentolamine which again shows promise for non-responders! Also in this class is yohimbine albeit weaker in effect then phentolamine.
There are of course other vascodilator drugs and for people that have hypertension switching to an ARB might be beneficial perhaps. I also know that there's some studies are showing the trazodone taking at night time might be effective in some people?
The point is by all this is there's a lot of avenues that can be approached and that I believe that we should have more access to these treatments. I'm a non-responder to just pde5 inhibitors and I have to go outside weird sources to get all these medications which is frustrating. Before I resort to injections or the last option of implants I myself am going to systematically check all these medications to see if they have any effect on me!!