PT-141 (Bremelanotide)

[Jeff775]

I would love to try PT-141 but I'm terrified of needles. No spontaneity is another downside: correct me if I'm wrong, but I believe you have to wait several hours for the effect of PT-141 to kick in.

If you're looking for a centrally acting drug that improves both erections and libido, I strongly recommend the apomorphine sublingual tablets from The ED Clinic. Apomorphine is not an experimental treatment, it was approved in Europe a few years ago (brand names Uprima, Zyprima).

It's a subcutaneous shot in the fat of your stomach...you don't even feel it man. For me it takes forever to kick in. If i'm gonna have sex that night I take it in the morning. But, nothing and I mean ABSOLUTELY NOTHING works as good as this does. Harder, bigger erections like you took a huge dose of viagra but somehow even more sensitive.

[Flavio]

[...] If you're looking for a centrally acting drug that improves both erections and libido, I strongly recommend the apomorphine sublingual tablets from The ED Clinic. Apomorphine is not an experimental treatment, it was approved in Europe a few years ago (brand names Uprima, Zyprima).

I'm afraid I'll have to correct this.

I only tried the apomorphine troches twice: at first, it showed some promise, but the second time was just BAD. Sedation, no arousal, mediocre erection, unbearable side effects. Same thing happened with cabergoline.

[Stew52]

Continuing from the above post (viewtopic.php?f=3&t=14728&start=10#p141727), I'm continuing on with testing doses and reactions. I left off at 1.8mg taken all at once based on one sites recommendation (the place I bought it from). To recap, therein there were mild positive effects and moderate side effects. Sorry this is so long.

Batch 2- Session 1 - 9 days later (new shipment) – Now to 2.0mg in two doses two hours apart. Did 0.10ml (1.0mg) at 9:27am, effects were mild and slower to develop, as a precaution I took shot of Afrin for the anticipated stuffiness. By 10:00am slightly stuffy and mild flushing, sore eyes, gurgling stomach; so far not a bad reaction. So hit with another 0.10ml at 11:28am. By 12:00noon reaction was minimal, a bit of a runny nose, gurgling, flushing gone. Characterize as mild. Effects vague but prone to plumping erection with minimal stimulation and more active nocturnal tumescence.

Batch 2-Session 2 - 4 days later - Since mild reaction last time at 2.0, did 2.5mg in one dose at 12:08pm (after sex actually).

Side effects - By 12:15 face flushing, within 30 min face very flushed, stuffy and sneezing fit, same at 1:28pm. Feels like a histamine reaction. At 1 hour, developed a really bad stomach into late afternoon, got chills (maybe due to cold weather), pretty much feel like shit into the evening 6-8pm, bad stomach, yucky, lots of gas/bloating, cramps and flatulence through the night, mild headache developed in PM to AM, still mild yucky stomach and stuffy next day 24 hrs later. I would characterize side effects here as more than moderate and not pleasant in the first 12 hours, and not then conducive to sex.

Effects – uncontrolled sexual lust. Had 5 spurious unprovoked erections which increased in intensity and duration though the evening/night and seemed to come in waves, nocturnal emissions on them all. #1@ ~6pm watching Yellowstone on sofa, quite plumped (90%) but not quite suitable for sex, lasted about an hour. #2@ ~8pm watching Tesla, lasted 1 1/2 hrs, full and hard, to bed at 9pm and clamped, huge glans. #3@ ~10:30pm lasting until 12:30am, very strong ticklish/burning/throbbing feeling in loins, genitals and base of penis, mini-orgasms when kegeling, could not sleep, felt like I'd explode, would have screwed a knothole, very randy, wanted sex. Wife was not into this rodeo so masturbated (worried about priapism if I fell asleep) in ~7 min (quick for me), huge massive orgasm and ejaculation which is good compared to normal (anorgasamia). Vague on following ones due to fatigue and delirium. #4@ ~2-4 AM, awoken, very strong, wanted sex again, like earlier, mini-orgasms prompted by grinding at base of penis or kegeling, very hard, lots of emissions. #5@ ~5-7am, like 2-4am, in and out of sleep. Worn out. Ticklish feeling AM and erection easily provoked but no auto-erections since arising. That day had a mild tingle in genital area. This night was over the top strange. Lusty as hell, strong horny feelings, auto-erections, quicker ejaculation (anorgasmia). Only slight tingle 2nd day and easily aroused and enhanced nocturnal tumescence; none the following days. So effects started at 6 hrs out and peaked between 10 to 20 hours out, seemingly in waves. This reaction would be out of control in public. The difference in reaction between 2.0 to 2.5 is breathtaking and actually kind of frightening. At this point, yea, it pumps libido/lust, seems to help with ED, helps with nocturnal tumescence, and anorgasmia but the side effects were bad for me. Need to evaluate dose and sequencing with partial shots.

[Stew52]

Batch 2-Session 3, 4 days later - a briefer recounting of the 3rd injection here and will follow in a separate post on conclusions. Down from 2.5mg to 2.0mg given in two 1mg injections two hours apart to see if side-effects could be reduced. Summary – it was much the same as the long post above, just less severe in both side- effects and effects.

Side-effects - the GI upset for me is the worst symptom, stomach ache, nausea, gas, bloating, cramps burping and cow flatulence, all ending in burning diarrhea the day after like I ate habanero stew. This happened last time but I discounted it but cannot now. The distress goes into the 2nd day and you just feel yucky; not much like having sex, which is the whole purpose. Al I’ve read in the lit Is ”some nausea” possibly treated with an anti-emetic. The rest are tolerable and subside in a few hours except the mild headache: flushing, burning eyes, heavy pulse, mild headache, stuffy sinuses and nose and drainage. I have read of women taking the FDA/Rx product getting “sicker than a dog”.

Sexual Effects – they were about 2/3rds of the above. First stirrings” noticed about 5 hours in like before with a spurious erection just talking about sex with my wife. It lasted well and I took advantage of the erection and feelings to masturbate up front rather than later to see how it affected the refractory period. It was quick and much better than usual, as with my anorgasmia it usually takes 20+ minutes if at all versus 12 min this time (7 min above). A 2nd stronger wave 2 ½ hours later (10:30) with a spurious erection and the “tingling/tickling/etc.” described above. I noted that the unit was really engorged and quite red, just as much so as with TriMix injections if not more and really plump when declining. Through the night there were a couple more waves with erections/nocturnal erections. [Note that nocturnal erections have been more commonplace for me every night taking 5mg of Cialis every night before bed (except tonite) but they are not usually rock hard. These were.] The last wave was about 5:30 (kinda a sleepless night) and I tried masturbating on the wave but to no avail after a tiring 25 minutes and sore arm and hand. The DE/anorgasmia crowd knows this well. Thorough the day here have been occasional minor stirrings and again, just talking about sex with the wife produced a nice erection in a minute. At 28 hours out now this is dissipating. This wave peak lasted between hours 8-14 and was nowhere near as intense as at 2.5 mg before.

[Stew52]

PT-141 Testing Conclusions – Side-effects and effects go up with greater doses and it appears not to be linear. And there is a lower threshold below which there is little apparent beneficial sexual effect but still some unpleasant side-effects, at least for me. More below.

Sexual Effects
1. That “sweet spot” probably varies with each person so some testing is needed. At the higher dose I did, 2.5mg, the sexual effects were profound, annoying and almost frightening. Many times through the might I would have screwed a knothole with firm erections lasting 1 ½ + hours and quite lustful and horny. This could go out of control at high doses. But it would be unproductive and frustrating for many with a longer refractory period and/or anorgasmia. Again that will vary with each person and age, etc. I now understand why bucks will cross a busy freeway to get to a doe in estrus. With multiple or near-constant spurious erections, and easy ones with a slight touch or talk of sex, planning public events would be unwise.
2. On Batch 1, I did an injection in the early evening and with the discomfort of the side-effects and a rushing feeling of anxiety, I just could not get to sleep. If you do it then, you might not sleep well and will be peaking in the AM exhausted with the peak lasting most of the day. That is if you have side-effects. So planning your tryst well comes into play. Ideally this situation would be ideal for a younger man with a shorter refractory period, no anorgasmia or DE, and planning an all-nighter or an all-dayer orgy or either with either several willing women or one willing wildcat to ride the many waves, if you can even get off.
3. Because the erections are conjured mentally, unlike TriMix injections, a PT-141 injection works on the brans sex center and erection can dissipate quickly if your head is not in it or distracted or at lower doses. Have a backup plan as you don’t want to disappoint anyone.
4. I’d need to test further but it appears it MAY help anorgasmia, subject to your refractory period, e.g. not hitting it too soon for your capability. I’d want to test this further. I don’t have any feeling if it affects the refractory period. As stated earlier, anorgasmia was my main reason for trying this at all. I have no libido problem for “our” sexual rhythm (age, refractory, recovery, etc.), and my ED is in hand OK with daily 5mg Cialis and TriMix.

Side-Effects – For me, at an efficacious dose for sexual effects, the side-effects were too bad. In fact the material made me kinda “sick feeling” for a couple of days. This is detailed int he previous posts. Sex was out of the question that evening and the next day. This may vary for you. The literature says, “you may experience some nausea and you may get horney”. In fact, I noted that the side-effects seemed to get worse with more use (Session 1 was 2mg with moderate side-effects and Session 3 was 2mg with worse side- effects). If you have a bad reaction there may be some increased sensitivity as with many allergies. I’ve said it kinda felt like a histamine reaction. In fact, I’m concerned with the severe GI involvement that I had, that it’s a medical consideration and will talk to my Uro. The heavy pulse is concerning also. The other stuff is manageable.

Bottom-line – for me without further research and consultation it’s a no-go for now. The side-effects just far outweighed the benefits, and some of the benefits are wasted on me: I don't need libido help, I have TriMix for ED, and getting off 5 times in 10 hours is not in the cards. But indeed using less TriMix would be great. Save one remaining interest that I may pursue further after some research for helping with anorgasmia, I’m on hold at least for a while. If I were 22 and had minor side-effects, and going to an orgy, and had a short refractory period, I’d consider it. I’m going to ask some questions on some of the other resources. Search YouTube for PT-141 for quite a few, including one that says it will make you a sex addict and is the devils work!!

Note: I prepared this detail not only for this great community but for my Uro who has no experience with PT-141 in their practice except for women’s libido problems. I have learned so much here and it’s nice to share something perhaps insightful back. If you have any questions or comments please fire away. Cheers.

[Stew52]

Two follow-up observations, posting separately in case you subscribed and would miss it as a PS.

1. You have read above that while side effects start quickly, the sexual effects only seem to start in some 4-6 hours and ramp up between say 10-18 hours out. (So a shot in the am peaks through the night.) The effects wear off rather quickly and on the following day, day 1, they are ~10% at best after early am - easier manual stimulation. By day 2 maybe 5% remains if that Maybe without ED that's enough to do it but with ED (me) it's not. It's a high steep peak on both sides.

2. The unit is much more plumped at rest (flaccid) on day 1 and 2. And dark red. Dunno why, maybe more blood flow? Perhaps the drug OR perhaps the result of having near constant intermittent boners for 14 hours!!

Your experience may vary.

[Stew52]

Again I apologize in advance for a longer post but since so little is published on this, I thought more info would be good. I have this in a Word doc or PDF if we can do attachments and I coul delete al these long posts.
--------------------------------
Prologue. The cup half full.
After a few days to think, I have a broader and clearer perspective. My thoughts were clouded by MY bad reaction in side effects to the drug. At an efficacious dose, they were intolerable. HOWEVER, subject to some caveats below:
If you do not have significant side effects, this drug MAY BY useful for HELPING with:
1. Libido – a good chance it enhances lust (libido, horny, call it what you may)
2. Penile PT – for a day or two it seems to enhance blood flow with a day or two of spurious (or mildly coaxed) erections and with more nocturnal tumescence (note -t I am taking 5 mg Cialis for this also but the reaction was increased)
3. ED –it seems to lower the threshold for an erection such that if you take drugs or do injections for ED that dose could be reduced and for milder cases MAYBE eliminated (again note that I am taking 5mg of Cialis daily which also helps here)
4. DE/Anorgasmia – it seemed to lower the threshold for ejaculation and (intense) orgasm at least manually, not tested vaginally (I have been testing Wellbutrin for 4 weeks with no apparent improvement)

The caveats, in no particular order:
• You have to carefully mix it with bacteriostatic water using syringes and inject it in fatty tissue (stomach fat). Some may not feel comfortable with this.
• Internet sites report a “buyer beware” caution on quality (strength, constituents and contaminants) from unknown non-FDA approved sites. My side-effects could be related to this or not. The only way to know would be to use the other sources, or the FDA-approved Rx women’s version (libido treatment). My Uro was wiling to Rx but I imagine a high cost or non-coverage for men or Medicare.
• The cost is not trivial. While optimistic internet reports cite foreign made (Chinese or Indian) PT-141 bought in large quantities (many boxes of many vials) could cost as low as $0.50 per 3mg treatment(??), low quantities (for testing or occasional use) from US sellers (Paradigm Peptites) was ~$50 for 10mg (or $10 for 5x2mg treatments) plus pills or injections. This makes regular treatment pretty expensive.
• The above narrative was for ME with my constitution, MY biases on side effects, MY intangible measurement of sexual effects, and limited in scope. Clearly NOT rigorous double-blind placebo -controlled testing. Your results WILL vary. It will require thoughtful testing to find your desired reaction(s) to varying doses and timing. Also note that I had a significantly larger reaction at 2.0mg vs 2.5mg, wildly horny, frighteningly so. High or regular use might create a monster.
• From that, you will need to test to find your desired reaction(s) for YOUR goals (libido, PT, ED DE), plural because maybe you have multiple goals at varying times like the one-off weekly versus the weekend orgy with the wildcat (refractory period and/or DE/anorgasmia may defeat that). And note that it IS used (Rx or non) to enhance women’s libido and sensual pleasure, so you could have a consenting wildcat. Also with spurious unprovoked erections you have to plan your social calendar appropriately.

Good luck if you do this. It has great potential.

[Flavio]

Continuing from the above post (viewtopic.php?f=3&t=14728&start=10#p141727), I'm continuing on with testing doses and reactions. [...]

Thank you for sharing your experience.

PT-141 seems interesting but my experiences with centrally acting drugs (apomorphine, cabergoline) were so bad, I probably won't give it a try.

Do you think men could use Vyleesi for ED?

[Stew52]

Continuing from the above post (viewtopic.php?f=3&t=14728&start=10#p141727), I'm continuing on with testing doses and reactions. [...]

Thank you for sharing your experience.

PT-141 seems interesting but my experiences with centrally acting drugs (apomorphine, cabergoline) were so bad, I probably won't give it a try.

Do you think men could use Vyleesi for ED?

1. My reaction to PT141 had bad side effects and variable sexual results.

My Uro was ready and willing to Rx Vyleese for me but I had already ordered the PT141. He was unfamiliar with its use in men but said it should act the same. I will price it for next time if there is one.

[Stew52]

PDF attached. ix (6) pages.