All of a sudden worsening erectile dysfunction

[mr.skin]

Hello to all,

I have a severe ed and can more or less coope with a high dose medication of pde5i.

But on friday I failed to get an erection for the first time in a long period of time and saturday morning again.

Yesterday and today while "testing" and masturbating I wasnt able to get a proper erection, not even with an injection.

Only thing which changed - I took high dose of prednisolone for 4 days (200mg/100/100/100) from monday to thursday last week.

I am really worried that something has happened. There is no pain.

I am devastated today, and anxious to meet my gf again in case i cant get it up again.

Any insights ?

[bldoink]

I'd not worry and give it a few more days. That was a pretty powerful drug and while I don't have the knowledge to give a definitive answer I wouldn't be at all surprised if the drug is still in your system causing ED issues. Give it some time and don't give yourself mentally induced ED worrying about it.

[mr.skin]

I think it should already be out the system.

Additionally last tuesday after the first two doses I actually had better erections.

I am going crazy rn, I cant get anywhere near hard.


There should not be any interaction with this drug. I cannot explain how this happened.

[Lost Sheep]

Hello to all,

I have a severe ed and can more or less coope with a high dose medication of pde5i.

But on friday I failed to get an erection for the first time in a long period of time and saturday morning again.

Yesterday and today while "testing" and masturbating I wasnt able to get a proper erection, not even with an injection.

Only thing which changed - I took high dose of prednisolone for 4 days (200mg/100/100/100) from monday to thursday last week.

I am really worried that something has happened. There is no pain.

I am devastated today, and anxious to meet my gf again in case i cant get it up again.

Any insights ?

Prednisone can cause erectile dysfunction. I would not think that it would make your PDE5 Inhibitor injection less effective, but the question needs to be asked. I suggest researching peer-reviewed medical journals for questions similar to this one: "Drug-induced sexual dysfunction" and read, looking for mentions of the length of time Prednisone remains effective in creating E.D. and if PDE5 inhibitors are affected by it.

Keep in mind bldoink's admonition to not let this turn of events "get into your head". There is no upside to that way of thinking and it is probably going down the wrong pathway.

[mr.skin]

Yes it can, but in long term use (at least I thought)

The corresponding search did not lead to any results.

I can just wait and hope.

[Simbarn]

Yes it can, but in long term use (at least I thought)

The corresponding search did not lead to any results.

I can just wait and hope.

I think you need to search a little more.
Prednisone is a stronger version of the original drug Hydrocortisone. It is longer acting and can have more side effects than the original medication Hydrocortisone.
It is a strong anti inflammatory drug. These class of drugs can interfere with erectile function in men with normal healthy erectile function.
Given you already have compromised erectile function, it would make perfect sense that the effect could be even more profound for you, especially as you have mentioned you were taking a high dose.

[mr.skin]

I did.

The only effect I am aware of is hypogonadal insufficiency, and adrenal insufficiency which should reverse itself.

There are no direct tissue effects I am aware of.

Tbh on the second day of the 4 day dosing scheme I had pretty good erections, it did start to detoriate on the third day, and got pretty worse on the 2nd day after finishing the scheme.

I found one stuey for high dosage short term in children which showed hpa axis suppression on day 3 but not on day 10 anymorey

[Simbarn]

I did.

The only effect I am aware of is hypogonadal insufficiency, and adrenal insufficiency which should reverse itself.

There are no direct tissue effects I am aware of.

Tbh on the second day of the 4 day dosing scheme I had pretty good erections, it did start to detoriate on the third day, and got pretty worse on the 2nd day after finishing the scheme.

I found one stuey for high dosage short term in children which showed hpa axis suppression on day 3 but not on day 10 anymorey

I must admit there was not a lot of information regarding a direct effect, other than a reduction in pituitary hormones.
I decided then to search a little on NO synthase and there was some information on how corticosteriods may affect this, especially in the airways.
I then looked into how they may affect vascular smooth muscle. There does seem to be a relationship with corticosteriods and vascular smooth muscle tone. With regard to possibly potentiating the effect of vasoconstrictors already in our body such as norepinephrine.
https://academic.oup.com/cardiovascres/ ... /55/317156
If one was to have an issue with increased sympathetic tone in the erectile tissues, which has been hypothesised to occur in older males, especially those with ED and or smooth muscle loss due to age or other reasons, the above could be relevant.

[mr.skin]

Thanks for all the input.

I am back to "normal" e.g. pre cortisol treatment function.

Just in case someone experiences the same,I think it took one week after the last pill to be back to baseline.