JimStars wrote:Adrenaline-like results are the result of using Epinephrine (called adrenaline in UK) or pseudoephedrine (mimics adrenaline) for counteracting Priapism erection so the mechanism is the same -- vasoconstriction.
Note that phenylephrine over the counter stuff is not the one you want for combatting priapism not that we are worrying about that in this thread.
Whether the worrying body can produce adrenaline in the same amounts as in a pill or epi-pen or spray -- who knows?
So stay cool and calm my friend!
J
Hi Jim,
Old topic, but you seem to have a lot (or some) knowledge about Epinephrine so i want to ask your thoughts about something.
Post Finasteride Syndrome is a disease where people have longlasting sexual side-effects after stopping Finasteride. There are many theories about the causes. Lately there was a study which in summary says:
"In support of our hypothesis, results revealed a reduction in the levels of epinephrine, with a concomitant increase of norepinephrine levels, coupled to no effect on PNMT protein levels. These findings suggest that the altered hormonal levels were due to a reduction of the enzymatic activity rather than to decreased levels of PNMT.”
"We believe that the present findings may help in explaining the various side effects reported by FIN users, in particular those related to sexual function "
" The noradrenergic system is also involved in the regulation of male sexual functions.[(50,51) The central control of erection is linked to ascending signals to the brain and descending ones to the spinal cord.[(51)]In addition, adrenergic innervation is strongly present in penile arteries and veins and in cavernosal smooth muscle.[(52)] In support, vascular control by the autonomic nervous system regulates erection.[(53)] The first phase of the erection cycle in humans is the flaccid state; then, upon stimuli, the penis reaches tumescence until complete rigidity, to conclude with the detumescence phase, back to the initial flaccid condition. Adrenergic control is involved in all erection phases.[(54)] Indeed, norepinephrine release in the penis induces the flaccid state by contracting the trabecular smooth muscle.[(55)]( Accordingly, in healthy men, a reduction in norepinephrine levels is associated with penile tumescence and erection, while an increased level of this hormone is associated with the transition from rigidity to detumescence.[(26)]Thus, norepinephrine is involved in transforming the penis from the erect to flaccid state.[(56)]In contrast to norepinephrine, epinephrine levels are increased in the tumescence phase in relation to the flaccid condition and then decreased in the rigid and detumescence phases.[(27)]Thus, these two hormones have opposite functions in penile erection. In human psychogenic and neurogenic erectile dysfunctions, the rigidity phase cannot be achieved. Interestingly, in these conditions, plasma norepinephrine levels are high in flaccidity, tumescence and detumescence phases, suggesting an impairment in adrenergic signals.[(27)] In summary, the balance of epinephrine and norepinephrine is crucial for achieving an erection.[(76,77)] Thus, based on the results we obtained, it is possible that FIN administration, by affecting PNMT enzymatic activity, is involved in the sexual problems reported by FIN users."
https://pubs.acs.org/doi/10.1021/acs.jm ... 39?ref=pdf "
Do you have any Idea how to combat ED in this case?
Thank you very much
