PED5 inhibitors stop working for 30yo

[Flavio]

[...] Where do you get udenafil from? Online source or do american pharmacies carry? I thought this was only available in asian? Thanks

I sent you a PM, we can't post links here.

[Stenlie_]

Hey all,

Looking for any idea of what might be going on here or any suggestions/solutions. Long story short, used Sildenafil for around 5 years (Starting around 26/27 years old) with great results, 25-50mg would give rock hard erections almost on-demand for 12+ hours. Went through a rough break-up about 2 years ago and the meds stopped working completely overnight. Even taking massive doses (upwards of 250/300mg), using multiple batches from different pharmacies, and trying tadalafil do nothing. I completely understand the mental/psychological component or erections are just as important as blood flow, but I am completely emotional removed from these events and still have not had any results remotely close to what I previously saw.

The strangest thing about all of this, and something I have found zero explanation for...I do not experience any side effects from the PED5i's, even at very high doses. Even if I was still suffering from the mental effects of the breakup, I should still see the systemic effects (face flushing, headache, congestion) from taking these meds, no? It is almost like the meds are not being absorbed.

Right now I am 35yo, in solid physical shape, fairly low stress levels, and eat predominately "clean"/healthy. I had a doppler ultrasound performed at a urologist office as well as testing for pelvic floor dysfunction with a pelvic floor specialized PT, both tests came back completely normal. My hormones are all along the mid-lower levels (free test 450-500), but I am about 2 weeks into TRT injections, hoping this will result in something. Has anyone hear of anything remotely resembling this or any thoughts/suggestions on what else I could try? If TRT doesn't result in something, I am likely looking at an implant.

Thanks,

Exactly the same here. There's no way anyone can convince me that the drugs don't stop working, just that the erectile function worsens. This does not happen in 1-2 days if there is no trauma or priapism. The drugs worked perfectly and suddenly they stopped. (provided that I did not overdose and took at most 10-15 times) Immediately the side effects disappeared. Right now I can take 150-200 sildanafil and not have any side effects. And before they stopped working I could have an erection of 50 and the side effects were really bad. I think it's all about hormones or NO or mental health.

[Flavio]

[...] Exactly the same here. There's no way anyone can convince me that the drugs don't stop working, just that the erectile function worsens. This does not happen in 1-2 days if there is no trauma or priapism. The drugs worked perfectly and suddenly they stopped. (provided that I did not overdose and took at most 10-15 times) Immediately the side effects disappeared. Right now I can take 150-200 sildanafil and not have any side effects. And before they stopped working I could have an erection of 50 and the side effects were really bad. I think it's all about hormones or NO or mental health.

Yes, I believe these drugs stop working and I can say it from my personal experience.

It happened with finasteride for hair loss: after 20 years of daily use, I had to change to dutasteride.

Same thing with PDE-5 inhibitors. I started with Cialis, now I take udenafil.

[Martin6469]

Gabapentin is a notorious orgasm inhibitor. Maybe erections too for some guys?

[timduncan]

l believe they lose efficacy too, just not sure about the mechanism. depends on how often we use them? or the tissue problem just get worse?

that would be nice to know