Is trimix made differently among pharmacies?

[macoza]

Hi guys.. I've talked to a few compounding pharmacies that told me their trimix expires at different times. It seems that not everyone makes trimix the same way. Is it true that pharmacies makes trimix differently?

[ElbowRoom]

Trimix is not a single formula, it's more a class of drug that contains the three different medications. Each compounding pharmacy has its own formulation with its own proportions of the three. If you ever change pharmacies look at the new label and compare it to the old one. If the doses of the three drugs are different, you need to start again with a small dose and titrate up to find your correct dose for that formulation. It's a pain in the ass, but compounded drugs aren't standardized so you have to have some more caution with them.

As to life of the drug...most say 90 days if kept refrigerated, but some might say 60 or 30. I have used Trimix almost a year old that has been refrigerated with no issues or loss of efficacy. Just shake it up a little each time, and check if it's clear. If it's cloudy just toss it to be safe. My urologist's PA confirmed to me "yeah it says 90 days, but if it's refrigerated it's closer to 'indefinite'."

[macoza]

If you ever change pharmacies look at the new label and compare it to the old one. It's a pain in the ass, but compounded drugs aren't standardized

As to life of the drug...most say 90 days if kept refrigerated, but some might say 60 or 30. I have used Trimix almost a year old that has been refrigerated with no issues or loss of efficacy.

Hi.. Appreciate the input. Would you please answer my questions in my thread here? It's very important.

viewtopic.php?f=5&t=26375&p=251733#p251733

[ElbowRoom]

If you ever change pharmacies look at the new label and compare it to the old one. It's a pain in the ass, but compounded drugs aren't standardized

As to life of the drug...most say 90 days if kept refrigerated, but some might say 60 or 30. I have used Trimix almost a year old that has been refrigerated with no issues or loss of efficacy.

Hi.. Appreciate the input. Would you please answer my questions in my thread here? It's very important.

viewtopic.php?f=5&t=26375&p=251733#p251733

I posted in that thread. Is there a specific question you have that didn't get answered?

[macoza]

I posted in that thread. Is there a specific question you have that didn't get answered?

Yeah I do have a specific question. Will 2 trimixes from 2 different pharmacies have differences in effectiveness? Would I have to adjust the dosage?

I ask cuz in a trimix from a previous pharmacy years ago I injected 3 units to get erect. With a trimix from a current pharmacy I need to inject like 10 units to get erect. So I'm now thinking of buying new trimix from the previous pharmacy.

[ElbowRoom]

I posted in that thread. Is there a specific question you have that didn't get answered?

Yeah I do have a specific question. Will 2 trimixes from 2 different pharmacies have differences in effectiveness? Would I have to adjust the dosage?

I ask cuz in a trimix from a previous pharmacy years ago I injected 3 units to get erect. With a trimix from a current pharmacy I need to inject like 10 units to get erect. So I'm now thinking of buying new trimix from the previous pharmacy.

Absolutely yes. I looked at the labels from two different pharmacies and the amount of the three medications were wildly different. "Trimix" is more a technique ('mix these three medications'), than a recipe. Every pharmacy is different, though there are often similarities in their "recipes".

Always re-titrate when you change pharmacies. Also whenever you get a new vial, back off the dose on that first shot. There is often not perfect quality control and one vial might be stronger or weaker than the last one.

[bldoink]

I have no first hand knowledge but I would expect there are standard practices all licensed compounders must follow. I'd think that would limit unexpected variation somewhat. Theoretically, if two compounders sell mixes listing the same amounts of the 3 drugs per ml then the mixes should act the same. Theoretically!

Some compounders have a set list of mixes that for whatever reason they think are the most appropriate or popular. Your doctor would have to pick from their menu. Obviously they should reflect a broad range of strengths.

There are some compounders that don't really compound their tri-mixes and basically just resell standard mixes from a larger compounder. Their offerings will be limited to whatever "standard" mixes their provider offers. They should be able to provide your doctor a list of their offerings.

Some compounders will prepare any mix the doctor choses to prescribe. My smaller compounder is like that. No need to pick from a list as they'll compound whatever the script says.

[macoza]

I have no first hand knowledge but I would expect there are standard practices all licensed compounders must follow. I'd think that would limit unexpected variation somewhat. Theoretically, if two compounders sell mixes listing the same amounts of the 3 drugs per ml then the mixes should act the same.
.

COMPLETELY WRONG!! Unfortunately there are no standards in formulating trimix as every pharmacy is different in compounding it. There should be standards cuz since there are not, patients will be left incredibly confused and frustrated not knowing that one trimix from one pharmacy differs in strength from another even if the prescription strength is stated the same in both trimixes.

This is how lawsuits are created against such pharmacies and even doctors who prescribe them. If you switch pharmacies with different formulas of trimix given that one trimix requires 10 more units than the trimix you were used to injecting from a previous pharmacy you can seriously injure yourself royally.

It's a very fucked up industry that the government should step into to set standards in order to prevent serious medical accidents from possibly occurring. The patient is unbeknownst to these operations and becomes the victim.

[GoodWood]

What is your Trimix prescription? List it here please so we know what you are talking about. How much prostaglandin? How much Papaverine? How much phentolamine?

[CanGetItUpButNotOff]

What is your Trimix prescription? List it here please so we know what you are talking about. How much prostaglandin? How much Papaverine? How much phentolamine?

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