Is trimix made differently among pharmacies?

[bldoink]

COMPLETELY WRONG!! Unfortunately there are no standards in formulating trimix as every pharmacy is different in compounding it. There should be standards cuz since there are not, patients will be left incredibly confused and frustrated not knowing that one trimix from one pharmacy differs in strength from another even if the prescription strength is stated the same in both trimixes.

I can't agree. Since the mixes are compounded individually in each pharmacy logic tells me there will be a tiny bit of variation between pharmacies or even between batches in a pharmacy. That's assuming it's a compounder that makes their own and aren't just resellers for one of the big ones. But the pharmacists are extensively trained and licensing for pharmacies that compound injection meds is pretty strict. I can see some pharmacists being a tiny bit heavy handed if they are wanting to make sure you get your money's worth. But I don't see them going heavy by much.

There are myriad different mixes offered by the various pharmacies plus the ones that compound custom per script. So you have to make sure you're comparing apples to apples. If I was switching to a different compounder, even using the same script, I'd back off my dose just a bit out of normal caution. However I haven't detected a noticeable difference between batches.

[ElbowRoom]

Compounded drugs are kind of a gray area with the FDA. They are not as tightly regulated as mass-produced prescription drugs. In *theory* if you get two batches with the same proportions of medications in them, say both 30mg PAP/1mg Phen/10mcg PGE (my current vial)...then they should act the same.

BUT. I had a pharmacy that was terrible on consistency, one vial was great and the next gave no effect at all. I took the bad vial back to them and they replaced it and all was well. But awful that they couldn't get it consistent. I fired them and got a different pharmacy which has been really good and consistent.

This is why I say you need to back off your first dose whenever you get a new vial. If they get it wrong and it's overly strong, you'll land in the ER. My normal dose is 0.14ml to 0.17ml. When I get a new vial my first shot is 0.10-0.12ml to make sure it works as intended.

[macoza]

I can't agree. Since the mixes are compounded individually in each pharmacy logic tells me there will be a tiny bit of variation between pharmacies or even between batches in a pharmacy. That's assuming it's a compounder that makes their own and aren't just resellers for one of the big ones. But the pharmacists are extensively trained and licensing for pharmacies that compound injection meds is pretty strict. I can see some pharmacists being a tiny bit heavy handed if they are wanting to make sure you get your money's worth. But I don't see them going heavy by much.

There are myriad different mixes offered by the various pharmacies plus the ones that compound custom per script. So you have to make sure you're comparing apples to apples. If I was switching to a different compounder, even using the same script, I'd back off my dose just a bit out of normal caution. However I haven't detected a noticeable difference between batches.

It doesn't matter if you agree with how compound pharmacies manage their compounding since this info comes directly from an experienced, licensed compound pharmacist himself. Trimix of the same strength, say for example trimix #5, will be different in variation from pharmacy to pharmacy to such an extent that dosages and potency will be different and will have to be adjusted. One trimix from one pharmacy worked for me with 3 units in dosage. But another trimix from a different pharmacy worked for me using 14 units in dosage. That's additional proof from personal experience.

As was mentioned before, compounding is a loosely regulated market that the FDA has little control over at least as far as trimix is concerned given how pharmacies mix them together. This is not apples to apples, its more like fuji apples to ambrosia apples. They're both apples but theyre different apple families.

If I was switching to a different compounder, even using the same script, I'd back off my dose just a bit out of normal caution. However I haven't detected a noticeable difference between batches.

I'm highly confused. Before you said that trimixes from various pharmacies are basically the same. Now youre advising to use caution when switching to a trimix from a different pharmacy. Its contradictory since there shouldn't be any danger according to you, since all trimixes from among pharmacies are the same.

[bldoink]

...say for example trimix #5, will be different in variation from pharmacy to pharmacy to such an extent that dosages and potency will be different and will have to be adjusted.

Trimix #5 tells me nothing. That's a term used by one or more different compounders with ingredients determined by each compounder. My pharmacy doesn't list any trimix numbers. Your doctor orderes a script and they make it. I would never make an assumption that a "trimix #5" from one pharmacy was the same as "trimix #5" from another. A compounder can call any mix they want "trimix #5". I would assume that a script for say 20/1/10 from one pharmacy would be close to that of 20/1/10 from another.

I'm highly confused...Its contradictory since there shouldn't be any danger according to you, since all trimixes from among pharmacies are the same.

Generally the same if the actual listed ingredients are the same. But some variation may occur. So use some caution. I never said the mixes would be exactly the same. In fact I said the opposite. It's not quite the wild west.

[macoza]

Trimix #5 tells me nothing. That's a term used by one or more different compounders with ingredients determined by each compounder.

Exactly! You prove my point.

My pharmacy doesn't list any trimix numbers. Your doctor orderes a script and they make it. I would never make an assumption that a "trimix #5" from one pharmacy was the same as "trimix #5" from another.

You prove my point again. If your pharmacy doesn't list trimix numbers while others do that further highlights the differences in trimix of the same script among pharmacies that have their own trimix formulas and ingredient proportions. No pharmacy necessarily has the same formula as all others.

I never said the mixes would be exactly the same. In fact I said the opposite. It's not quite the wild west.

It actually IS the wild west. If a patient gets his trimix from a certain pharmacy for years then all of a sudden changes uro and pharmacy, the new script will NOT be the same as his old one even with the same trimix number.

This is why the government MUST intervene to regulate this market else men will only get seriously hurt not knowing the make up and proportions of their trimix. This market must be standardized only to prevent incredible harm in the form of unnecessary priapism, loss of nerves, tissue damage, peyronies, agony, mental anguish and suicide.

[bldoink]

Just ignore what trimix # they give it. It means nothing. Just look at the actual ingredients and their amount per milliliter, as in mg or mcg per ml.

[CanGetItUpButNotOff]

To properly assess whether different compounding pharmacies compare with one another, it's important to differentiate between the branding "TriMix #X" vs "TriMix Y/Y/Y", where "X" is an arbitrary naming designation that will vary between pharmacies and "Y" refers to specific formulations of Papaverine, Phentolamine and PGE1. There is no reason to expect that one pharmacy's "X" is comparable to another. But there should be an expectation that any reputable compounding pharmacy will be close, probably very close, to the same "Y/Y/Y" mix.

[GoodWood]

To properly assess whether different compounding pharmacies compare with one another, it's important to differentiate between the branding "TriMix #X" vs "TriMix Y/Y/Y", where "X" is an arbitrary naming designation that will vary between pharmacies and "Y" refers to specific formulations of Papaverine, Phentolamine and PGE1. There is no reason to expect that one pharmacy's "X" is comparable to another. But there should be an expectation that any reputable compounding pharmacy will be close, probably very close, to the same "Y/Y/Y" mix.

Great answer. CanGetItUpButNotOff and BDOINK have it right.

Pharmacies ARE regulated and you can safely expect that switching from one compounding pharmacy to another will be fine when the prescription is listed as Y mcg/cc PGE1, Y mg/cc Papaverine. and Y mg/cc Phentolomine.
Thinking TriMix #1 or TriMix #3 means the same thing everywhere is like thinking “ExtraStrength” or “Super” will mean the same thing everywhere. It’s not the case. But not a sign that the system is broken and needs further regulation.

[GoodWood]

Education about the components of TriMix and their role will help with understanding how this works. Having a provider who can tweak the script for the best effect for YOU as well as a compounding pharmacy that can make custom mixes can help you get the best erection possible.

These screenshots are taken from a brochure Wedgewood Pharmacy provided. (Wedgewood no longer makes Trimix but the information is still valid.)

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IMG_4254.jpeg (93.83 KiB) Viewed 401 times

[ElbowRoom]

This is why the government MUST intervene to regulate this market else men will only get seriously hurt not knowing the make up and proportions of their trimix. This market must be standardized only to prevent incredible harm in the form of unnecessary priapism, loss of nerves, tissue damage, peyronies, agony, mental anguish and suicide.

I'd philosophically disagree with this point. IMO we don't need government to intervene on our behalf. We need patients to take responsibility for their own health, do their research and act rationally and not just trust what some Urologist says because he's wearing a white coat.

Just my opinion, others can certainly disagree. I would just rather be in charge of my health and medications than Big Daddy Government.