freezing trimix

[frank53]

question
I just got my new Rx from Talon pharmacy today, It states on the vial do not freeze? past vial and old pharmacy did not say that. Have been freezing my trimix in the past.should I freezing it or not ??
Thanks any help frank

[rahod1]

Definitely!!! I keep mine frozen at all times, except to thaw for an injection...then back in freezer.
It maintains potency 100% for a year (or more).

[JimStars]

The only issue with freezing Trimix (or Bimix) is the possibility that Papaverine (and maybe Phent) will precipitate out as crystals. That would, of course, make the shot way below its proper strength. This might ONLY happen if your formula has 30 mg Pap and 2 mg Phent since those are near maximum amounts that can be dissolved in 1 ml. PGE-1 is never an issue since it is infinitely dissolvable for any practical amounts.

Very few have reported this happening, but also if you do not look closely you could easily miss it since it may just sit on the bottom or may look like bubbles if you shake it or could even be a single giant near transparent crystal (i have seen that).

Once it precipitates out it is a bugger to get it to dissolve back again.

So ... after you thaw, just take a good look. Swirl it, shake it, tip it slightly back and forth ... holding up to a strong light all the time, That would include looking in a thawed syringe too -- harder to to but take a look after shaking it.

J

[once a writer]

Do a search on this site for your title — freezing trimix. You'll find a ton of information in previous posts by experienced users. The consensus: Yes, you should.

[rahod1]

The only issue with freezing Trimix (or Bimix) is the possibility that Papaverine (and maybe Phent) will precipitate out as crystals. That would, of course, make the shot way below its proper strength. This might ONLY happen if your formula has 30 mg Pap and 2 mg Phent since those are near maximum amounts that can be dissolved in 1 ml. PGE-1 is never an issue since it is infinitely dissolvable for any practical amounts.
J

I use 20ugPGE/2mg phent/30mg Pap/...per Ml concentrations. I have no problem keeping frozen. Clear as bell when thawed.

[JimStars]

Yeah I can't say why it might or might not come out as crystals ... better water?? heh.

Jim

[postra7777]

I had mine crystalize before but was able to get them to dissolve back in after vigorous shaking. It does happen.

[tomas1]

I have the exact same formula from 2 sources.
One says "always keep in freezer".
The other says "never freeze".
I freeze it and so far it looks and acts fine.

[rahod1]

I have the exact same formula from 2 sources.
One says "always keep in freezer".
The other says "never freeze".
I freeze it and so far it looks and acts fine.

I could never understand the *Never Freeze" notification! It's a PROVEN no brainer that freezing will keep trimix potent for over a YEAR! I know this for a fact. Also, there is a published study that demonstrated freezing was FAR superior to refrigeration.

[dtwarren1942]

Mine (five 2ml vials) comes frozen in a dry ice pack with a label advising to keep frozen until ready to use.