After viagra started to fail, I moved on to Trimix injections which were very effective for about three years at 15 mgs. Then, I slowly had to increase the dose and strength until 75 mgs at triple the strength couldn’t get the job done.
I now rely on a VED and two Osbon tension bands to get the job done. Even here I had to add a second tension band to maintain a hard erection.
Tolerance to cialis and viagra
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Re: Tolerance to cialis and viagra
Age 81
Diabetic
Pumping
Started Trimix injections 8/'11
Diabetic
Pumping
Started Trimix injections 8/'11
Re: Tolerance to cialis and viagra
I think what needs to be included in this discussion is the process of aging.
Perhaps we forget that the penis is affected by this as other parts of our bodies are.
Some people need hip replacements at age 50 or knee replacements. Our eyes start failing for many of us at age 40.
Joints start to give us problems in mid-life. Our ability to perform at many sports starts to decline rapidly after age 30!
Put simply our bodies are just not what they were at age 50 as they were at age 25. We might like to think they are but they are not.
By the time 7- 10 years have passed we have completely replaced the cells in every part of our bodies. So by the age of 50 you have been reincarnated many times. Every time this happens deterioration occurs in every cell. Essentially it’s a disease process that everyone gets.
So of course the penis suffers the same fate, for some men, even more so than other parts of our bodies. The structures of the penis are not as robust as we were led to believe when we were young. PDE5 inhibitors help for a period of time to lessen the symptoms of aging in the penis. However, this process of “aging” continues unabated.
Therefore for some of us, just as our hips wear out and a hip replacement is needed so do the functional aspects of the penis fail, and some of us need a “penis replacement”. We are fortunate in these times that this option is available.
Lifestyle, genetics, diet and exercise also play a very important part in this. Some guys can have good erectile function for the greater part of their lives and others not.
On demand PDE5 inhibitors work for some of us during this inevitable change in our bodies. Eventually they fail because the elements in the penis they help to boost, deteriorate too much and the effect they have is negligible.
Perhaps we forget that the penis is affected by this as other parts of our bodies are.
Some people need hip replacements at age 50 or knee replacements. Our eyes start failing for many of us at age 40.
Joints start to give us problems in mid-life. Our ability to perform at many sports starts to decline rapidly after age 30!
Put simply our bodies are just not what they were at age 50 as they were at age 25. We might like to think they are but they are not.
By the time 7- 10 years have passed we have completely replaced the cells in every part of our bodies. So by the age of 50 you have been reincarnated many times. Every time this happens deterioration occurs in every cell. Essentially it’s a disease process that everyone gets.
So of course the penis suffers the same fate, for some men, even more so than other parts of our bodies. The structures of the penis are not as robust as we were led to believe when we were young. PDE5 inhibitors help for a period of time to lessen the symptoms of aging in the penis. However, this process of “aging” continues unabated.
Therefore for some of us, just as our hips wear out and a hip replacement is needed so do the functional aspects of the penis fail, and some of us need a “penis replacement”. We are fortunate in these times that this option is available.
Lifestyle, genetics, diet and exercise also play a very important part in this. Some guys can have good erectile function for the greater part of their lives and others not.
On demand PDE5 inhibitors work for some of us during this inevitable change in our bodies. Eventually they fail because the elements in the penis they help to boost, deteriorate too much and the effect they have is negligible.
Age 57, ED issues for 15-20 years. Testosterone replacement with Enanthate and Ovidrel. Currently using generic Tadalafil 2.5mgs and Resveratrol daily.
Re: Tolerance to cialis and viagra
That sounds about right Simbarn. And just like there are a few young people who need a hip replacement at a younger age, like a young person who develops avascular necrosis, some people are affected by ED at an unusually young age. Hard not to take it personally LOL, but you got to deal with it as best you can like everything else in life
40 y/o straight married guy with supportive wife. Slowly progressive ED from venous leak since adolescence. Pills were a godsend for years, now as the efficacy fades, I am wading into the land of injections and implant
Re: Tolerance to cialis and viagra
Peruse this, just posted it. viewtopic.php?f=3&t=15485
Add: It discusses the potential in some for some penile rehab and workarounds. My progress has been good. We had rocking sex this AM for nearly an hour without an injection. First time in 3 3/4 years. Then a low dose injection, lower than usual, for a stronger closing. Now this said I agree "Simbarn" that I and we are working against the clock. Imagine if I started this rehab at 48 when I started pills and could get by with perhaps a much lower dose and NOT progress to injections, etc.
For you and the fellow who answered me there, it may be time for an implant. I agree that this is important to a good healthy relationship. Years ago my GP Dr said we may just have to chill and go to Starbucks and hold hands. That is now a standing joke in the house as we romp regularly after study and hard work.
Add: It discusses the potential in some for some penile rehab and workarounds. My progress has been good. We had rocking sex this AM for nearly an hour without an injection. First time in 3 3/4 years. Then a low dose injection, lower than usual, for a stronger closing. Now this said I agree "Simbarn" that I and we are working against the clock. Imagine if I started this rehab at 48 when I started pills and could get by with perhaps a much lower dose and NOT progress to injections, etc.
For you and the fellow who answered me there, it may be time for an implant. I agree that this is important to a good healthy relationship. Years ago my GP Dr said we may just have to chill and go to Starbucks and hold hands. That is now a standing joke in the house as we romp regularly after study and hard work.
Last edited by Stew52 on Tue Sep 29, 2020 7:24 pm, edited 1 time in total.
NOT an MD. 72, M52 yrs, CenTX US. Inj since 12/2016, a yr after pills stopped working. Caverject for a yr. 1/2018 Tri-Mix at 30 pap/2 phent/60 pge @0.3ml, now 0.5ml 80mcg/ml PGE1. DE/Anorgasmia setting in since 5/2019, worse now.
Re: Tolerance to cialis and viagra
Simbarn wrote:I think what needs to be included in this discussion is the process of aging.
...
Absolutely.
I'm 44, not getting any younger and I know this only too well.
In the case of ED, however, the mind also plays a major role and experience is a plus.
Age 40. Psychogenic ED for over 20 years. Current regimen: Udenafil 200 mg, oral phentolamine mesylate 40 mg, Seredyn.
Re: Tolerance to cialis and viagra
I have the same condition here. I am 35 and had great results w/ 25mg sildenafil for more than 7 years, However, things has rapidly changed for the last couple of months. It is horrible. It is affecting my marriage/mental health and I have no idea how to deal with it.
I tried cialis 20 mg and got mixed results. I heard some of you said Avanafil works pretty well. Is there anybody else who uses Avanafil or any other pill that works better if you develop tolerance to sildenafil or cialis?
Thanks.
I tried cialis 20 mg and got mixed results. I heard some of you said Avanafil works pretty well. Is there anybody else who uses Avanafil or any other pill that works better if you develop tolerance to sildenafil or cialis?
Thanks.
Re: Tolerance to cialis and viagra
It does not seem unusual to develop "tolerance" to the pills and/or for the underlying condition to worsen requiring more drug over time. Over 15 years I progressed from 25 to 50 to 75 to 100 mg Viagra where the side effects were bad and the Rx starting to fail. I was on mostly Viagra but tried Levitra and Cialis and then Stendra later. The Uro suggested mixing it up a bit. Now some say it's only the underlying condition worsening BUT after 5 years boner-drug-free, I am now having a pleasant result with only 5 mg of Cialis. Been doing injections for nearly 4 years now and no boner drugs. I am back on 5 mg Cialis "maintenance dose" to help penile rehab (or so the theory and studies go) and use a lower injection. I have also been taking cardio enhancement supplements like L-Arginine and NO (Neo40, etc.) Sounds like some of you are ready if not overdue for some penile rehab and/or injections. My 2 cents.
Last edited by Stew52 on Wed Sep 30, 2020 10:24 am, edited 2 times in total.
NOT an MD. 72, M52 yrs, CenTX US. Inj since 12/2016, a yr after pills stopped working. Caverject for a yr. 1/2018 Tri-Mix at 30 pap/2 phent/60 pge @0.3ml, now 0.5ml 80mcg/ml PGE1. DE/Anorgasmia setting in since 5/2019, worse now.
Re: Tolerance to cialis and viagra
Stew52 wrote:It does not seem unusual to develop "tolerance" to the pills and/or for the underling condition to worsen requiring more drug over time. Over 15 years I progressed from 25 to 50 to 75 to 100 mg Viagra where the side effects were bad and the Rx starting to fail. I was on mostly Viagra but tried Levitra and Cialis and then Stendra later. The Uro suggested mixing it up a bit. Now some say it's only the underlying condition worsening BUT after 5 years boner drug-free, I am now having a pleasant result with only 5 mg of Cialis. Been doing injections for nearly 4 years now and no boner drugs. I am back on 5 mg Cialis "maintenance dose" to help penile rehab (or so the theory and studies go) and use a lower injection. I have also been taking cardio enhancement supplements like L-Arginine and NO (Neo40, etc.) Sounds like some of you are ready if not overdue for some penile rehab and/or injections. My 2 cents.
What do you exactly mean with "penile rehab"?
Re: Tolerance to cialis and viagra
whymenow wrote:What do you exactly mean with "penile rehab"?
The notion that you can reverse or stabilize or slow ED with various treatments to some degree. There are several posts in page one of this folder that discuss this and an article posted about research in Germany: viewtopic.php?f=3&t=15354.. And a whole folder on Penile PT. Read up!
Here is one I did recently. Peruse this: viewtopic.php?f=3&t=15485
Last edited by Stew52 on Wed Sep 30, 2020 11:57 am, edited 3 times in total.
NOT an MD. 72, M52 yrs, CenTX US. Inj since 12/2016, a yr after pills stopped working. Caverject for a yr. 1/2018 Tri-Mix at 30 pap/2 phent/60 pge @0.3ml, now 0.5ml 80mcg/ml PGE1. DE/Anorgasmia setting in since 5/2019, worse now.
Re: Tolerance to cialis and viagra
Stew52 wrote:whymenow wrote:What do you exactly mean with "penile rehab"?
The notion that you can reverse or stabilize or slow ED with various treatments to some degree. There are several posts in page one of this folder that discuss this and an article posted about research in Germany. And a whole folder on Penile PT. Here is one I did recently. Read up!
Peruse this, just posted it. viewtopic.php?f=3&t=15485
Thanks a lot!
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