Trimix-freeze or not to freeze

[ThatTallGuy]

It's the alprostadil that loses potency quickly when not frozen. If your tri-mix isn't really alprostadil dependent then alprostadil degradation won't really be noticed much if at all. I suspect that in a mix heavy with alprostadil you will notice degradation fairly rapidly.

Keep in mind I'm not a medical or pharmacological expert of any kind. I did not sleep in a Holiday Inn Express last night.

So Alprostadil should always be kept in the freezer and not the fridge?
How many hours can Alprostadil survive in room temperature if I wanna hook up with some girl and have a prefilled syringe with me? Does it lose efficacy in 2-3 hours or longer?

I tried a little experiment awhile back where I left a syringe out in room temperature for 48 hours and then tried it. No issues.
Then I tried it for over 60 hours at room temp. No issues and it didn't turn cloudy.
I now carry some syringes in a Zip-lok baggie in my suitcase without a cold pack, then pop them in the fridge when I get where I'm going and have had no problems with potency.

[denmark3400]

if you dont need Alprostadil (for example i dont need) you can store it in room temperature. Only Alprostadil loses efficiency if not in refrigerator.

[Magic Rat]

Does anyone have any issues with air bubbles while freezing Trimix in syringes? I've tried it and saw a little air bubble when I thawed the syringe. Got the willies about injecting it (ahem), so I thawed the bottle and started over. Admittedly the air bubble is not a big one, but it gave me cause for concern. Should i be concerned about air bubbles?

[Martin6469]

I read a urologist's advice that a grain-of-rice size bubble is ok, and I've injected that size many times without a problem. But I see no reason to freeze Trimix. I've used Trimix with papaverine, phentolamine, and prostaglandin, kept at 40F (4C) for months, letting it go to room temperature for 16 hours in a pre-loaded syringe before use, and it's good as new.

[brian188]

My compounding pharmacy told me to keep all of the vials in the freezer. Use one vial at a time, and then it can be placed back into in the frig as long as it it is kept cold for next time.