Tolerance to cialis and viagra

[otter17]

Hi all,

I had the misfortune to develop ED is my teens. Fortunately a combination of viagra and cialis carried me through the better part of 10years with functionally hard dick. Sadly, over the last few months I have found the regimen less reliable, and have had some failures again. I understand that this may be my aging dick saying he’s fed up with it all and ready to retire to floppy-town.

However, my intake PDE5s has picked up recently, going from a couple times a week to about every other day, as we are trying to have kids.

So is it possible that by taking the meds for so long and so often that I have developed tolerance. The few studies I saw showed minimal displays of tolerance, and loss of efficacy was just based on worsening of the underlying organic problem.

But who knows? Does anyone have any anecdotal experience where thery took a break from cialis/viagra/Levitra, and the when later took the drugs, found them more effective again?

[Dirk Winston]

I have had much of the same experience. I began to suffer from ed in my early 20s by my early 30s Viagra came on the market and it was a miracle drug. It could bring the dead back to life. However, after nearly 20 years of use its potency began to decline to were it was barely working at all. I began taking large quantities even as much as 900mg of Viagra and even at that level its affect was minimal at best. At higher levels I could respond provided I had a skilled and dedicated oral female partner who knew her technique and was willing to put in the time and patience to get me there. It did not matter which brand I used Viagra Cialis Levitra the result was pretty much the same they were not working to barely working at best even at higher quantities.

I have read on here many guys saying the same thing that the potency of PDE5s declines and stops working after a few years. I have looked for studies but have not found much I dont think the pharmaceutical companies want to fund any such study and dont want the public to know that the PDE5s wont work for everyone and after a few years their potency declines and even stops. This is a billion dollar industry for the pharmaceutical companies so they are not eager for the public to know that the PDE5s decline in potency after a few years.

I have however, become a bit of a health nut exercising regularly strict natural diet, supplements eight hours of sleep and have had some potency return from the PDE5s. Not quite where I would like it to be and perhaps not where it was at its peak when the PDE5s were working great but I am no longer at the depths of ed that I was just a few years ago when the PDE5s had pretty much stopped working.

I think trying to change your life around and keeping a healthy diet exercise sleep supplements and you may see some return to the effectiveness of the PDE5s.

[AnotherOldMan]

...the potency of PDE5s declines and stops working after a few years

I wonder if after the effectiveness declines and one quits PDE5's for x number of years, if all or a large part of the former effectiveness returns?

I have seen no studies on this.

[wolfpacker]

The few studies I saw showed minimal displays of tolerance, and loss of efficacy was just based on worsening of the underlying organic problem

I think you're correct in your findings. There is no "tolerance" like we see with other drugs like caffeine, but rather the cause of ED tends to just get worse over time, causing the PDE5 drugs to help less and less.

[dtwarren1942]

...the potency of PDE5s declines and stops working after a few years

I wonder if after the effectiveness declines and one quits PDE5's for x number of years, if all or a large part of the former effectiveness returns?

I have seen no studies on this.

Viagra started failing to be effective about ten years ago and I moved on to injections and pumping. I do occasionally try Viagra But with little if any positive results.

I believe the Primary reason Viagra starts failing Is because the underlying cause of the ED has worsened. In my case, the complications of diabetes.

[otter17]

I have had much of the same experience. I began to suffer from ed in my early 20s by my early 30s Viagra came on the market and it was a miracle drug. It could bring the dead back to life. However, after nearly 20 years of use its potency began to decline to were it was barely working at all. I began taking large quantities even as much as 900mg of Viagra and even at that level its affect was minimal at best. At higher levels I could respond provided I had a skilled and dedicated oral female partner who knew her technique and was willing to put in the time and patience to get me there. It did not matter which brand I used Viagra Cialis Levitra the result was pretty much the same they were not working to barely working at best even at higher quantities.

I have read on here many guys saying the same thing that the potency of PDE5s declines and stops working after a few years. I have looked for studies but have not found much I dont think the pharmaceutical companies want to fund any such study and dont want the public to know that the PDE5s wont work for everyone and after a few years their potency declines and even stops. This is a billion dollar industry for the pharmaceutical companies so they are not eager for the public to know that the PDE5s decline in potency after a few years.

I have however, become a bit of a health nut exercising regularly strict natural diet, supplements eight hours of sleep and have had some potency return from the PDE5s. Not quite where I would like it to be and perhaps not where it was at its peak when the PDE5s were working great but I am no longer at the depths of ed that I was just a few years ago when the PDE5s had pretty much stopped working.

I think trying to change your life around and keeping a healthy diet exercise sleep supplements and you may see some return to the effectiveness of the PDE5s.

It’s good to hear that you have had some recovery. It can be a little depressing to think that erections can only get worse over time, not better. It may be only in my mind, or coincidence, but I think that my erections have been a little better when I have focused on lower body workouts like squats.

And one thing that may suggest at least a degree of tolerance/tachyphylaxis, is that my side effects from the same dose of viagra (stuffy nose, flushing), seem to be less than previously too

[Flavio]

Excellent topic!

Cialis stopped working for me after 10 years of regular use. Same thing with Propecia for hair loss, after 20 years.

I can't really complain, both treatments worked really well for a long period of time, thank God for that.

I'm now taking Spedra (avanafil) instead of Cialis and it works great. Avanafil has fewer side effects and a shorter half-life, I can't praise it enough. Consult your doctor before you decide to start Spedra or any other new treatment.

[Simbarn]

It is far more likely that what ever condition one has that is causing erectile dysfunction is deteriorating further as the years go by.
Levels of NO in the endothelium could be less available and or smooth muscle loss in the erectile tissues may be increasing. These two factors will lower the effectiveness of a particular on demand dose of a PDE5 inhibitor.
Remember, PDE5 inhibitors used as an on demand medication are not a cure for erectile dysfunction, they just help to ameliorate the symptom.
Long term low dose PDE5 inhibitor therapy has been shown scientifically to work in a very different way, by attenuating fibrotic changes in the erectile tissues and even restoration of smooth muscle loss.

[Stew52]

I came up with unacceptable ED at 48 y/o. Was rock hard with a throbbing purple head up to that. Any position worked. Me on bottom in any configuration was wifey's faves. I used pills, mostly Viagra, for 15 years, from 48-62, in a dose increasing from 25 to 50 to 100mg where the side effects were bad (stuffy, joint aches, red eyes, headache) and the erection was slipping. from 62-63 y/o, the Uro tried me on a couple different pills, Stendra and Cialis, to no great effect. And then we pretty much laid of for a sad year at 64. I've read the other posts here and don't know if the meds lost efficacy or my underlying condition just got worse, or some combo of both. I have read many times in this site that a layoff for a while helps. Long story short here now, also had low T and treated it, and 4 years ago I found injections and that has been a rebirth. Have injected for nearly 4 years now and, while it's not without issues on that journey in progress, it is a relative nirvana. More on this soon elsewhere.

[harvey6389@att.net]

Thanks guys for straight talk. I too used viagra,, cialis and Levitra all worked ok for about twelve or thirteen years, Levitra was my prefered worked faster with less dyspepsia,but all became much more expensive and less effective. I can get an erection with pde5s but without stimulation lasts about thirty seconds. Made a visit to the urologist and he said that I had a venous leak and said that I should try penile injections or consider a prosthesis. Wow, that did not turn out like I hade hoped. I decided to try ici first and yes they do work and plan to use them as long as they don't cause fibrosis or peyronies. I 'm not to worried about priapism with venous leak unlikely said the doctor. If they do stop working I will start making plans for a prosthesis. For me life without intimasy is just un acceptable. I am a young 70 with a 35 year old fiance. Not in a midlife crisis or dirty old man. Just finally found my soul mate.