New pharmacy says don’t refreeze trimix. Will “degrade”

[thunderball]

I’ve always re-frozen my trimix. I thaw it out, prefill a bunch of syringes. When I use all those syringes, I thaw again and prefill more. If I recall correctly these are the instructions my old pharmacist gave me 3 or 4 yrs ago. he also indicated that the ‘expiration date’ was somewhat bogus, but they were required to put 30 days on the label.


My last refill of 10ml w old pharmacy was early Feb 2025. I just used that up last week. My new refill w new pharmacy was July 7 2025.

The new pharmacy told me to not refreeze the new vial after I had pierced it w a needle. They said the formula would degrade. So I should store it in the fridge, and discard after 30 days.

I asked if they were worried about bacteria if I’m refreezing. They said no, the issue is decreased strength of formula.

This seems crazy to me. In my mind I believed more degradation would happen in the refrigerator?

The current price for 10ml is $135 US. When freezing I’m getting 3 to 4 months out of a vial.

If I discard after 30 days obviously I just get a month’s use.

I know a number of you refreeze like I have. Any thoughts on this? Should I just keep doing what I’m doing? Or is the pharmacy correct?

[bldoink]

I have no medical training or expertise so my advice means nothing.
Unless there's something special about their mix I'd keep doing what I was doing. If there is something special about their mix I'd find another compounder.

[TOSDMS]

I don't refreeze my trimix i use all the trimix to fill my syringes put them in plastic tubes with cap i got on Amazon and freeze them all use as i need been doing it this way for years works great for me i have used some that have been frozen for 9 months they worked fine it may be that if you thaw at room temperature it might degrade over time every time you thaw it might be better to thaw in a refrigerator

[Budward]

I think it is nonsense. I have frozen my vials since I started, the last I actually pulled 33 injections out of a 5ML bottle bringing my cost for having a great hardon to 5 bucks a episode. Great value and I am loving my rejuvenated sex life which is better that even when I was a teenager.

[thunderball]

Thanks guys for the replies.

FWIW here’s an article I found on the National Library of Medicine that seems relevant:

https://pubmed.ncbi.nlm.nih.gov/23924676/

Int J Pharm Compd
. 2004 May-Jun;8(3):231-5.
Long-term stability of trimix: a three-drug injection used to treat erectile dysfunction

Lawrence A Trissel 1 , Yanping Zhang
Affiliations expand
PMID: 23924676
Abstract

A three-drug injection mixture of alprostadil 12.5 microgram/mL, papaverine hydrochloride 4.5 mg/mL and phentolamine mesylate 0.125 mg/mL in bacteriostatic 0.9% sodium chloride injection was evaluated for stability at 23 deg C, 4 deg C, -20 deg C and -70 deg C. The injection remained clear and colorless in all samples throughout the study.

Chemical stability testing was performed using stability-indicating high-performance liquid chromatographic analysis. Alprostadil was the least stable of the drug components at room temperature and under refrigeration. About 8% alprostadil loss occurred in five days at room temperature; under refrigeration losses of about 6% and 11% occurred after 1 and 2 months, respectively. Frozen at -20 deg C and -70 deg C, less than 5% loss of any of the drug componenets occurred in 6 months.

A beyond-use date of 6 months when stored frozen at -20 deg C and 1 month when stored refrigerated at 4 deg C is appropriate for batches of the injection that have passed sterility testing. Room temperature exposure should be limited, and the vial should be returned to refrigeration as soon as possible.

—————
My main thing is I want to make sure I don’t hurt myself by storing ‘improperly.’ Given my experience over these years I don’t think I am.

I put a call into my current uro’s office yesterday to see what he says. Not heard anything yet, so will forward this article abstract.

[GoodWood]

The topic of freezing comes up regularly. The topic of degradation of the prostaglandin at room temp even more so. This article (although 21 years old) illustrates what I saw in my own experience: Trimix doesn’t degrade at room temp NEARLY as much as you’d think. From reading comments here on FrankTalk you would think that room temp Trimix needs to be thrown out after just a few hours. This study shows that at 5 days it had only shown an 8% degradation. 5 DAYS!

I stopped worrying about Trimix temp sensitivity over the years. It just wasn’t an issue for me.

I did keep it refrigerated but if I drew up a shot and didn’t use it until 8, 10,12 hours later (at room temp) it was never a problem.

I once tried drawing up syringes and keeping them in the freezer. But many of mine thawed with the needle plugged and the medication could NOT be given. Very frustrating to stick a needle in my dick and not be able to deliver the med.

I think it is generally a good idea to listen to medical professionals. There may be some aspect of the solution this pharmacy uses when compounding the Trimix that makes it prone to issues when freezing/thawing.

My take away from all of this is that storing Trimix in the fridge and NOT freezing it is fine. There is minuscule loss of effectiveness over time.

[ElbowRoom]

I've kept vials in the fridge a year and they are still good to go, so I never considered freezing. But I wouldn't be afraid of it either. If you've tried it and it's still effective after thawing, I'd carry on.

The only time I wouldn't shoot is if it gets cloudy instead of clear like water.

[thunderball]

I think it is generally a good idea to listen to medical professionals.

Absolutely! Don’t want to do anything to harm myself or my treasured penis.

There may be some aspect of the solution this pharmacy uses when compounding the Trimix that makes it prone to issues when freezing/thawing.

My take away from all of this is that storing Trimix in the fridge and NOT freezing it is fine. There is minuscule loss of effectiveness over time.

Good stuff.

Off Topic: reading your implant journal. Wonderful info and I’m learning a lot. Glad it is working so well for you. And congratulations on the Porno Dick (tm)! May have some questions for you sometime.

[thunderball]

The only time I wouldn't shoot is if it gets cloudy instead of clear like water.

Thank you Elbow. I’ve only had one go cloudy on me, straight to the trash! Never used that compounding pharmacy again.