Trimix and Tadalafil Combination - good idea or bad idea?

[Steve_ED]

I am just now starting Trimix injections. I have had 3 so far and have not found my correct dosage yet. Prior to starting this I was taking 20 MG daily Tadalafil for BPH (one half in the morning and one half at night). This worked very well for my BPH. I am wondering if at this point, maybe 10 MG daily would be enough for my BPH. I have read a few messages where guys said they combined Cialis and Trimix. I have also read online and was told by my urologist, it’s not a good idea to mix them. Course my urologist also said not to take even 10 mg of Tadalafil daily.

I am considering starting my Tadalafil back, but only 10 mg a day to try to get my BPH under control again. At the same time, I am thinking maybe start back over at .05 ML for Trimix. I think my formula is a rather weak formula? This is my formula: TRIPLE MIX INJ (IJPC) 15MG/0.5MG/10MCG/ML. My urologist said to start at .20 ML. Based on recommendations from others, I started at .05 ML. My plan was once I found my Trimix injection to stop Tadalafil for 3 days and then inject. But if it is possible and safe, I would rather continue Tadalafil daily and inject Trimix as needed (Maybe a lower dose of Trimix because the Tadalafil will still be in my system)? I was not prescribed the antidote, but I do have 30 MG Psudoephedrine. So if that does not work, I guess I will be going to the ER if it becomes necessary? I would really like to avoid that though ……

If anyone has tried combining the two. What dose of Tadalafil were you using and what dose of Trimix were you using? Did you use a lower dose of Trimix because the Tadalafil was still in your system? Did the combination work better for you? Did it cause priapism? I am wondering if I get back on Tadalafil (maybe 10mg instead of 20mg) and start over at .05 ML of Trimix, then maybe I could find my trimix dosage and not have to worry about stopping Tadalafil on days that I inject.

Any thoughts or experience you could share would be appreciated …

Thank you

[ape1100]

My trimix formula is a step up from yours. I use 5mg tadalafil daily that was prescribed by the same uro. He wanted to start me on 30 units but I convinced him to do half for the first injection and that was too strong. I have now titrated down to using 5 units. I believe the daily regimen allows me to use less trimix than needed. I inject twice a week now have plenty of erections that last 4-5 hours sometimes. They are never painful so I know I’m no where near a priapism. Trimix just works well for me. I had heard that viagra and cialis were not to be taken together but this same uro had me on that combo prior to injections but that was when I used them on demand.

[bldoink]

Steve, welcome to the forum.

Any thoughts or experience you could share would be appreciated …

I'm not a doctor or medical professional of any kind. Anything I post is based on my own experiences at best and hallucinations and/or delusions at worst. Internet forum advice is likely worth what you paid for it, or worse. Always ask your doctor and follow his/her advice.

Medical advice from legitimate sources that advise you to never mix the two are pretty easy to find.

I'm not a legitimate source and have little experience with tadalafil. It doesn't like my tummy. I do mix sildenafil with my alprostadil injections fairly often with no known ill effects. When I told my then new Uro that I was mixing them he asked me why with a very questioning look on his face. I explained that it allowed me to use a lower dose of the alprostadil. He just replied "OK" and that was the end of the topic. Keep in mind that I had a RRP over 11 years ago and I have been using injections for a good while and know how my body reacts. I'm experienced. None of the pills alone will give me anything approaching an erection. I tell you this so that you will understand that my experiences may not be typical and yours may be very different.

However, it is my understanding that the combination is becoming more common and acceptable. Here is a link to a couple of abstracts of an articles on the topic. You can't read much of the articles at the links but you may be able to track down the full studies if you try: https://www.nature.com/articles/s41443-018-0046-2 and https://clinicaltrials.gov/ct2/show/NCT00507286#outcomemeasures.

Perhaps tracking down some very legitimate research papers to show your doctor may convince him to help you try the combination therapy out. Most doctors have big egos so you should be very tactful so as not to piss him/her off.

Should you decide to proceed with this alone I'd certainly advise doing it slowly and with reduced doses. I think I'd figure out my proper injection dose first and then reduce it while trialing a very small dose of tadalafil.

[Steve_ED]

Thank you ….. Once I find my correct dosage. I think I will start back on 10 mg daily Tadalafil to see if that will help my BPH. If not, I will go back to my daily 20 mg Tadalafil. Once I start Tadalafil back, should I drop my Trimix dose in half to start or start back over at say .05 ML?

[bldoink]

...Once I start Tadalafil back, should I drop my Trimix dose in half to start or start back over at say .05 ML?

I edited my prior post and added a 2nd link.

Your questions are best answered by a doctor. They should be answered by a doctor. I have no idea what your current response is from the pills. And really even if I did I'd just be making a bubba internet guess on an answer, but it's your dick so here's my answer if you're foolish enough to listen to me. Yes, error on the side of caution and start back to your starting point, the 5 units.

[Steve_ED]

Thank you ….. I would expect my urologist to say not to mix them. But I will have a new urologist after the end of the month and it might be worth talking to him about it.

[qcswral]

Like others have said, I am not a doctor and can only give you my own experience with taking Tadalafil and Trimix together. First off my Tadalafil dose is much lower than yours, more like 5mgs per day for BPH. Secondly, my Trimix strength is much stronger than yours ( PGE 100 PHE 3 PAP 30) and I take anywhere between 25-30 units. I can lower the dosage (20 units) when my Trimix is new right after the script is filled. I have never had an issue with priapism and I've been injecting over 10 years and been on the Tadalafil a good 5+ years. I will also take a 100mgs of Viagra about an hour before injecting...and still never had a problem. If I do get a dull ache after sex, I place a frozen bag of peas on my crotch after the woman I see leaves my place.
The bottom line is you have to kind of experiment with what works best for you...but I would lean to the conservative side.. Everybody is different and your responses to the mixing the Trimix with Tadalafil may be very different than mine. I would also discuss it with your URO guy. Having a close friend who is a retired Doc, he has told me physicians are trained to error on the side of caution...and no Doc is looking to be sued for giving off the road advice on these things. I often have said on this forum, in all the years I've been on Trimix and on this forum I've never had an erection lasting longer than 1 hour. IDK if guys on here exaggerate, or my penile arteries are so clogged that it's impossible for me to have such a long lasting erection...plus I do have some venous leakage..I wear a cock ring to help that too...Welcome to the wonderful world of Trimix where it's mostly a shot in the dark ( no pun intended) as to your dosage strength and combinations of ED meds while injecting..Good luck!!

[ETGuy71]

My urologist prescribed the 5mg of Cialis and I take it daily whether or not I was going to use the Trimix didn’t concern him!

[Steve_ED]

Thank you. When I start back on Tadalafil, I think I am going to start with 10 mg and see if that will be ok for my BPH. I felt like 20 mg might be to much, that is why I cut it in half and took half in the morning and half at night. I suppose at any point I had 10 mg or more in my system at at time.

[Steve_ED]

For those of you who are using Tadalafil and Trimix together. Did you stop taking Tadalafil and find your dosage for Trimix and then start back on Tadalafil with a reduced dose of Trimix? Or were you taking Tadalafil, did not stop taking Tadalafil and just started Trimix on a low dose?