No usable results with more powerful trimix

[toronaga07]

I originally was prescribed Trimix at papaverine=30,phentolamine=2,prostaglandin=20. The results were not usable even at max dose.

Went to another doc at Duke and was told to ask the compounding pharmacy if they had a stronger mix. Got trimix with papaverine=150,phentolamine=20,prostaglandin=200. Have been trying it with increasing dosages with no luck. Max dose is 100 units and I'm up to 70. Is there any point to increasing it past this?

[easymoney]

Hi, my recent experiences with the injections started out on bimix ..then went to trimix .. then even stronger trimix .. in the end even at 100ml of trimix #13 the next step would have been trimix #16 and at a 100ml of the #13 is like starting out at 70ml on the #16 trimix ... I never got anything more than a bit of fullness no real firmness ..and the pain was incredible ... I'm now awaiting my malleable implant surgery on june 30th 2023.Dr. only wants to do a malleable due to my health issues and age ...

[Martin6469]

toronaga: Are you sure you're injecting into a corpus cavernosum? I have thin hard-to-hit corpora and it took me a lot of practice. I have to locate the corpus exactly with the thumbnail of my free hand first. Misfires are usually, but not always, accompanied by swelling on the injecting side.

[bldoink]

I originally was prescribed Trimix at papaverine=30,phentolamine=2,prostaglandin=20. The results were not usable even at max dose.

Went to another doc at Duke and was told to ask the compounding pharmacy if they had a stronger mix. Got trimix with papaverine=150,phentolamine=20,prostaglandin=200. Have been trying it with increasing dosages with no luck. Max dose is 100 units and I'm up to 70. Is there any point to increasing it past this?

I've never heard of a mix with 20mg of phentolamine. I've never heard of a mix with 150mg of papaverine either. I'm guessing your new mix is given as per 5ml vial. I would bet your new stronger mix is actually, when figured per ml, a 30/4/40 mix. That's still kind of high for phentolamine. Obviously stronger than your original mix but not crazy strong, although the phentolamine is high. If per a 10ml vial your mix could even be a per ml mix of 15/2/20. That would be a little weaker than your original mix if the original was written as per ml.

How big is your vial and what exactly does it say? For that matter your original mix would be a per ml mix of 6/.4/4 if it was written as per 5ml. Olympia Compounding's chart lists a starting mix (T-50) of 8/.29/2.9 per ml. There are too many unknowns. But your mix is not a 150/20/200 per ml mix.

It's unfortunate there is so little standardization among compounding pharmacies as to mixes and how they list the ingredients. But there isn't. My observation is that the most common methods are to write the ingredients as per one ml and in the order of Papaverine/Phentolamine/Prostaglandin (Alprostadil). That way, for example, Olympia's T105 mix of 30/1/10 will be listed as 30/1/10 whether in a 1ml vial, a 5ml vial or even a 10ml vial. All common vial sizes. However that is not currently the case. There is apparently no national standard.

For example here is a link to a PDF of Olympia's offerings (I've never done any business with them): https://www.olympiapharmacy.com/wp-content/uploads/2018/05/TriMix-Prescription-Form-WEB.pdf

Have you ever had an injection by the doctor in his/her office? To get no reaction leads me to think you're missing and your technique is off. I did an amateur injection video awhile back that some have found helpful. I can PM you a link if you like. Unfortunately I have it on google drive and it seems you can no longer play it from google drive and it must now be downloaded first to be viewed. Let me know if you want me to give you the link and we can just hope you can view it.

I hope all of that was reasonable understandable.

Good luck.

[ShouldIwait]

Normally the first injection is done by your doc in his office. Why didn't that happen in your case? That would at least confirm you were injecting properly.

[GoodWood]

I originally was prescribed Trimix at papaverine=30,phentolamine=2,prostaglandin=20. The results were not usable even at max dose.

Went to another doc at Duke and was told to ask the compounding pharmacy if they had a stronger mix. Got trimix with papaverine=150,phentolamine=20,prostaglandin=200. Have been trying it with increasing dosages with no luck. Max dose is 100 units and I'm up to 70. Is there any point to increasing it past this?

Seems like you need to have a conversation with your urologist. Have him look at the mix you are currently using. Have him determine if there is a significantly stronger prescription that can be written. If you aren’t getting decent results with 70units the next prescription needs to be 4 or 5 times more powerful. Most compounding pharmacies charge the same price for a 10ml vial regardless of the concentration. So it’s much more economical to be injecting 10 or 15 units each time than 70 or 100 units.

Are you getting ANY reaction? If so, what is it? Is your penis getting erect at all?

[GoodWood]

Hi, my recent experiences with the injections started out on bimix ..then went to trimix .. then even stronger trimix .. in the end even at 100ml of trimix #13 the next step would have been trimix #16 and at a 100ml of the #13 is like starting out at 70ml on the #16 trimix ... I never got anything more than a bit of fullness no real firmness ..and the pain was incredible ... I'm now awaiting my malleable implant surgery on june 30th 2023.Dr. only wants to do a malleable due to my health issues and age ...

Just to clarify: I’m pretty sure you mean 100units of Trimix, not 100ml. The injectable ED meds are usually prescribed in units. 100units = 1ml. So 100ml of Trimix would be 10,000units. You’d need a turkey baster for a syringe.

[easymoney]

sure comfort brand insulin syringes .... 1cc (1ml)... 5/16 length .... 31 guage ... does that clear it up?

[bldoink]

Yeah, you were confusing U-100 insulin units with CC's and ml's. To do 100 ml's of the mix you would have injected 100 syringe fulls of the mix in those syringes. That might take awhile.

Also, saying you were using trimix #13 or trimix #16 means nothing to us. Those are terms specific to that pharmacy. Do you know what the actual mixes were?

[easymoney]

Yeah, you were confusing U-100 insulin units with CC's and ml's. To do 100 ml's of the mix you would have injected 100 syringe fulls of the mix in those syringes. That might take awhile.

lol .. well I ended up using 100 units at a time and still got no results I was very disappointed with the whole experience .. Disappointed in how the dr handled the doppler examine .. should have given a large enough dose to see if it would work instead of letting me waste 500.00 and 3 months of my life fooling with it to only tell me they could see by the doppler that I had major issues and they sort of eluded to the fact they knew it at the end of the doppler ..

Also, saying you were using trimix #13 or trimix #16 means nothing to us. Those are terms specific to that pharmacy. Do you know what the actual mixes were?

No I don't but it's MenMD over in St. Pete if you contact them you can get the exact ration of what the different mies are .. they ship but since I lived fairly close I just went and got my order ..