Supplements that increase PDE5 effectiveness?

[shyyguy123]

I've read that Grapefruit Juice and Pomegranate can increase absorption of PDE5's by a significant margin. I've also read that they can be dangerous too though. Potential for priapism and a hazardous drop in blood pressure.

I have not tried either and don't plan too. BUT...

I take daily combo of L-Citrulline and Grape Seed Extract. I also take a PDE5 as needed to help with my venous leak. I've found that the L-Citrulline and Grape Seed Extract seem to increase PDE5 effectiveness in a similar fashion. It's a welcome effect for me because I need all the help I can get to maintain an erection (cock ring too). I've scoured the internet and yet to find any warnings about dangerous interactions between the 3.

Anyway my reason for creating this thread is twofold:

1. Does anyone know if this effect is the same interaction as PDE5 + Grapefruit/Pomegranate? Is it dangerous?

2. If it's not dangerous maybe it can help others like it's helped me. Just BE CAREFUL.

[newtoed]

I googled it and grapefruit juice actually inhibits the absorption of these drugs. The best effect I get is empty stomach and keeping busy for one hour. I get less erection laying on my back. Standing, kneeling is the best. If you plan intercourse try to get 100% hard before entering, you will last lot longer.
Les

[shyyguy123]

I think you read it wrong. It does delay it but not inhibit it. Grapefruit juice both delays and increases absorption of PDE5s.

It increases absorption by about 23% according to the findings I've seen.

[bw1951]

I've been told by a doctor that grapefruit juice enhanced cialis, but I haven't tried it. The same doctor suggested letting the pill dissolve under the tongue instead of swallowing it.

[dtwarren1942]

Absorbtion under the tongue works better than ingestion for soft medications. However, Cialis pills are hard and it would probably remain under your tongue for several hours. Accordingly, you would need to get the Cialis in liquid form (Iron Eagle) for this process to work well for you.

[JimStars]

dt/bw,

When I was trying out sildenafil or tadalafil I would simply take a sip of water in my mouth and chew up the pill and swish it around with the water and saliva for as long as I could before getting bored then swallow. Problem of dissolving pill is solved.

Can't say it ever really worked, although I could feel the flush -- just never did anything else for me.

Yes they taste bad all chewed up .. but hey .. MAN UP! No whining! Your manhood is on the line here and you WILL do anything it takes.

J